Pathogenicity of multiple organ failure induced by seasonal and highly pathogenic avian influenza virus infection and its therapeutic options
| Project/Area Number |
24249059
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KIDO Hiroshi 徳島大学, 疾患酵素学研究センター, 特任教授 (50144978)
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| Co-Investigator(Renkei-kenkyūsha) |
CHIDA Junji 徳島大学, 疾患酵素学研究センター, 助教 (10437651)
MIZUNO Dai 徳島大学, 疾患酵素学研究センター, 助教 (70380061)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
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| Keywords | インフルエンザ / 重症化機序 / 治療法 / バイオマーカー / 診断法 / 多臓器不全 / エネルギー代謝 / 血管透過性亢進 / 重症化 / 季節性インフルエンザ / 高病原性鳥インフルエンザ / 代謝障害 / プロテアーゼ阻害剤 / 血管内皮細胞機能障害 / エネルギー代謝障害 |
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| Outline of Final Research Achievements |
Influenza A virus (IAV) causes significant morbidity and mortality. We have studied the viral pathogenicity and the host cellular factors involved in the pathogenicity of multiorgan failure (MOF). We proposed a new concept on the pathogenicity of MOF, the“influenza virus-cytokine-trypsin”cycle interconnected with the“metabolic disorders-cytokine". These cycles provide new treatment concepts for ATP crisis and MOF. One is diisopropylamine dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase 4 for glucose metabolism and the other is bezafibrate which up-regulates long-chain fatty acid metabolism. We also identified that IAV infection induces GSK-3β-mediated β-catenin degradation in the adherens junctional complexes and induces vascular hyperpermeability. Furthermore, we established SmartAmp system for detection of thermolabile carnitine palmitoyltransferase 2 SNPs as risk factors for influenza associated encephalopathy in the infected young children.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Anti-influenza activity of C60 fullerence derivatives.2013
Author(s)
Masaki Shoji, Etsuhisa Takahashi, Dai Hatakeyama, Yuma Iwai, Yuka Morita, Riku Shirayama, Noriko Echigo, Hiroshi Kido, Shigeo Nakamura, Tadahiko Mashino, Takeshi Okutani, Takashi Kuzuhara
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Journal Title
PLoS ONE
Volume: 8(6)
Issue: 11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunomodulator clarithromycin enhamces mucosal and systemic immune responses and reduces re-infection rate in pediatric patients with influenza treated with antiviral neuraminidase inhibitor: A retrospective analysis.2013
Author(s)
Wakako Shinahara, Etsuhisa Takahashi, Takako Sawabuchi, Masaru Arai, Nobuo Hirotsu, Yoshio Takasaki, Shizuo Shindo, Kyoko Shibao, Takashi Yokoyama, Kiyoshi Nishikawa, Masahiro Mino, Minako Iwaya, Yuji Yamashita, Satoshi Suzuki, Dai Mizuno, Hiroshi Kido
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Journal Title
PLoS ONE
Volume: 8(7)
Issue: 7
Pages: e70060-e70060
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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