How is immunological accommodation induced in ABO incompatible kidney transplantation?
Project/Area Number |
24249078
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Niigata University |
Principal Investigator |
TAKAHASHI KOTA 新潟大学, 医歯(薬)学総合研究科, 客員研究員 (90101857)
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Co-Investigator(Kenkyū-buntansha) |
SAITO Kazuhide 新潟大学, 医歯学総合病院, 講師 (20262438)
NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817)
YAMAMOTO Tadashi 新潟大学, 医歯学系, 教授 (30092737)
IMAI Naofumi 新潟大学, 医歯学総合病院, 臨床検査技師 (50599165)
NAKAGAWA Yuki 新潟大学, 医歯学総合病院, 助教 (70422607)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
Fiscal Year 2014: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2013: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2012: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
|
Keywords | 腎移植 / ABO血液型不適合 / 抗原抗体反応 / 糖鎖抗原 / 血管内皮細胞 / 交差抗原性 / 脱感作療法 / 免疫学的順応 / ホスト免疫系因子 / グラフト内皮細胞因子 / 血液型不適合 / 血液型糖鎖抗原 |
Outline of Final Research Achievements |
We have publidhed many articles and books on elucidation of the mechanism of induction of "immunological accommodation" in ABO-incompatible kidney transplantation. In the manuscript, we have reviewed the history of ABO incompatible kidney transplantation worldwide and in Japan, our pioneership and destination in the role and importance of " desensitization therapy" in the field. The most ultimate goal is the elucidation of the induction mechanism of immunological accommodation in which we have clarified the variety of ABO carbohydrate antigens and antibodies in biomimicry to those of bacteria, RBC and vascular endothelial cells that closely related to the immunological accommodation induction in ABO incompatible kidney transplantation. Our hypothesis and evidence verified by clinical and experimental approach may lead to the improved patient and graft survival not only in kidney but also in other organ transplantation fields.
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Report
(4 results)
Research Products
(160 results)
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[Journal Article] Relationship between the Peripheral Lymphocyte Response to Mycophenolic Acid in vitro and the Level of ATP in Peripheral CD4+ Lymphocytes before and after Renal Transplantation.2014
Author(s)
Sugiyama K, Tsukaguchi M, Sasahara H, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Takahashi K, Tanaka S, Onda K, Hirano T.
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Journal Title
Drug Res (Stuttg)
Volume: Epub
Pages: Epub
DOI
Related Report
Peer Reviewed
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[Journal Article] Laparoscopic fenestration for a symptomatic lymphocele in renal graft after living-donor kidney transplantation2014
Author(s)
Ishikawa S, Tasaki M, Imai N, Ikeda M, Kasahara T, Sekijima M, Tomita Y, Nakagawa Y, Saito K, Nishiyama T, Takahashi K.
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Journal Title
Nihon Hinyokika Gakkai Zasshi
Volume: 105(3)
Pages: 139-143
Related Report
Peer Reviewed
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[Journal Article] Profiling of kidney vascular endothelial cell plasma membrane proteins by liquid chromatography-tandem mass spectrometry2013
Author(s)
Zan Liu, Bo Xu, Masaaki Nameta, Ying Zhang, Sameh Magdeldin, Yutaka Yoshida, Keiko Yamamoto, Hidehiko Fujinaka, Eishin Yaoita, Masayuki Tasaki, Yuki Nakagawa, Kazuhide Saito, Kota Takahashi, Tadashi Yamamoto.
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Journal Title
Clin Exp Nephrol
Volume: 17
Pages: 327-337
DOI
Related Report
Peer Reviewed
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[Presentation] 新潟大学における腎移植後悪性腫瘍の検討2015
Author(s)
池田正博、中川由紀、田崎正行、齋藤和英、高橋公太
Organizer
第48回日本臨床腎移植学会
Place of Presentation
名古屋市、ウェスティン名古屋キャッスル、日本
Year and Date
2015-02-04 – 2015-02-06
Related Report
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[Presentation] Present Status of ABO Incompatible Kidney Transplantation in Japan -Lessons From More Than 2,400 Cases to Date-.2014
Author(s)
K. Saito, A. Aikawa, S. Takahara, S. Teraoka, S. Fuchinoue, N. Yoshimura, K. Uchida, K. Tanabe, T. Kinukawa, Y. kamiryo, K. Yamada, C. Ohyama, S. Sato, K. Takahashi
Organizer
World Transplanbt Congress 2014
Place of Presentation
San Francisco,CA, Moscone Convention Center, USA
Year and Date
2014-07-26 – 2014-07-31
Related Report
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[Presentation] 先行的腎移植の実際と今後の展望2014
Author(s)
齋藤和英、中川由紀,田﨑正行、池田正博
Organizer
第59回日本透析医学会学術集会・総会
Place of Presentation
神戸市、神戸国際会議場、日本
Year and Date
2014-06-12 – 2014-06-15
Related Report
Invited
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[Presentation] 腎移植における腎性貧血治療2014
Author(s)
酒井 謙、齋藤和英
Organizer
第59回日本透析医学会学術集会・総会
Place of Presentation
神戸市、神戸国際会議場、日本
Year and Date
2014-06-12 – 2014-06-15
Related Report
Invited
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[Presentation] 献腎移植の現状と今後2014
Author(s)
中川由紀、齋藤和英、菊池雅美、相川 厚、高橋公太
Organizer
第102回日本泌尿器科学会総会
Place of Presentation
神戸市、神戸国際会議場、日本
Year and Date
2014-04-24 – 2014-04-27
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