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Development of neuroprotective treatment for incurable ocular diseases

Research Project

Project/Area Number 24249082
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

YOSHIMURA Nagahisa  京都大学, 医学(系)研究科(研究院), 教授 (70211662)

Co-Investigator(Kenkyū-buntansha) IKEDA Ohashi Hanako  京都大学, 医学部附属病院, 准教授 (20372162)
KAKIZUKA Akira  京都大学, 大学院生命科学研究科, 教授 (80204329)
IMAMURA Hiromi  京都大学, 白眉センター, 特定准教授 (20422545)
Project Period (FY) 2012-10-31 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2012: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords神経保護 / 眼難治疾患 / 眼細胞生物学
Outline of Final Research Achievements

We have examined neuroprotective effects of inhibitors for ATP activity of VCP on glaucoma and retinal degeneration animal models. The inhibitors suppressed decrease of the retinal ganglion cells and thinning of the retinal nerve fiber layer in NMDA-induced acute injury model, DBA2J, and GLAST knockout mice. The inhibitors suppressed decrease of photoreceptor cells and worsening of vusual function in rd10, rd12 mice and model rabbits of retinitis pigmentosa. The VCP ATPase inhibitors might protect neural cells by reducing decrease of ATP and ER stress in the cells.
The VCP ATPase inhibitors may be a new treatment for ocular diseases.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Products Report
  • Research Products

    (51 results)

All 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (14 results) (of which Invited: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 3 results)

  • [Journal Article] KUS121, an ATP regulator, mitigates chorioretinal pathologies in animalmodels of age-related macular degeneration.2018

    • Author(s)
      Muraoka, Y., Yoshimura, N., et al.
    • Journal Title

      Heliyon

      Volume: 4 Issue: 5 Pages: e00624-e00624

    • DOI

      10.1016/j.heliyon.2018.e00624

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of valosin-containing protein by Kyoto University Substances (KUS) as a novel therapeutic strategy for ischemic neuronal diseases2017

    • Author(s)
      Ikeda HanakoOhashi、Hata Masayuki
    • Journal Title

      Neural Regeneration Research

      Volume: 12 Issue: 8 Pages: 1252-1252

    • DOI

      10.4103/1673-5374.213540

    • NAID

      120006870290

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.2017

    • Author(s)
      Hata M, Ikeda HO, Kikkawa C, Iwai S, Muraoka Y, Hasegawa T, Kakizuka A, Yoshimura N
    • Journal Title

      Sci Rep

      Volume: - Issue: 1 Pages: 44873-44873

    • DOI

      10.1038/srep44873

    • NAID

      120006222005

    • Related Report
      Products Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Changes in morphology and visual function over time in mouse models of retinal degeneration: an SD-OCT, histology, and electroretinography study.2016

    • Author(s)
      Hasegawa T, Ikeda HO*, Nakano N, Muraoka Y, Tsuruyama T, Okamoto-Furuta K, Kohda H, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 60 Issue: 2 Pages: 111-125

    • DOI

      10.1007/s10384-015-0422-0

    • Related Report
      Products Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration.2016

    • Author(s)
      Hasegawa T, Muraoka Y, Ikeda HO, Tsuruyama T, Kondo M, Terasaki H, Kakizuka A, Yoshimura N.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 31184-31184

    • DOI

      10.1038/srep31184

    • NAID

      120005829364

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroprotective Effects of VCP Modulators in Mouse Models of Glaucoma.2016

    • Author(s)
      Nakano, N. et al.
    • Journal Title

      Heliyon

      Volume: 2 Issue: 4 Pages: 96-96

    • DOI

      10.1016/j.heliyon.2016.e00096

    • Related Report
      Products Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of sex and age on the normal retinal and choroidal structures on optical coherence tomography.2015

    • Author(s)
      Ooto, S., Hangai, M. & Yoshimura, N
    • Journal Title

      Curr Eye Res

      Volume: 40 Issue: 2 Pages: 213-225

    • DOI

      10.3109/02713683.2014.952828

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast2015

    • Author(s)
      Ohnuma Y, Takata T, Kawawaki J, Yasuda K, Tanaka K, Kimura Y, Kakizuka A.
    • Journal Title

      FEBS Lett.

      Volume: 589 Issue: 5 Pages: 576

    • DOI

      10.1016/j.febslet.2015.01.017

    • NAID

      120005531440

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alterations in the neural and connective tissue components of glaucomatous cupping after glaucoma surgery using swept-source optical coherence tomography.2014

    • Author(s)
      Yoshikawa, M., Akagi, T., Hangai, M., Ohashi-Ikeda, H., Takayama, K., Morooka, S., Kimura, Y., Nakano, N. & Yoshimura, N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 1 Pages: 477-484

    • DOI

      10.1167/iovs.13-11897

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetry analysis of macular inner retinal layers for glaucoma diagnosis.2014

    • Author(s)
      Yamada, H., Hangai, M., Nakano, N., Takayama, K., Kimura, Y., Miyake, M., Akagi, T., Ikeda, H. O., Noma, H. & Yoshimura, N.
    • Journal Title

      Am J Ophthalmol

      Volume: 158 Issue: 6 Pages: 1318-1329

    • DOI

      10.1016/j.ajo.2014.08.040

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging of photoreceptors in macular microholes.2014

    • Author(s)
      Ooto, S., Hangai, M., Takayama, K., Ueda-Arakawa, N., Makiyama, Y., Hanebuchi, M. & Yoshimura, N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 9 Pages: 5932-5943

    • DOI

      10.1167/iovs.13-13792

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive molecular diagnosis of a large cohort of japanese retinitis pigmentosa and usher syndrome patients by next-generation sequencing.2014

    • Author(s)
      Oishi, M., Oishi, A., Gotoh, N., Ogino, K., Higasa, K., Iida, K., Makiyama, Y., Morooka, S., Matsuda, F. & Yoshimura, N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 11 Pages: 7369-7375

    • DOI

      10.1167/iovs.14-15458

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wide-field fundus autofluorescence abnormalities and visual function in patients with cone and cone-rod dystrophies.2014

    • Author(s)
      Oishi, M., Oishi, A., Ogino, K., Makiyama, Y., Gotoh, N., Kurimoto, M. & Yoshimura, N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 6 Pages: 3572-3577

    • DOI

      10.1167/iovs.14-13912

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa.2014

    • Author(s)
      Nakagawa, S., Oishi, A., Ogino, K., Makiyama, Y., Kurimoto, M. & Yoshimura, N
    • Journal Title

      Clin Ophthalmol

      Volume: 8 Pages: 1487-1493

    • DOI

      10.2147/opth.s66326

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cone abnormalities in fundus albipunctatus associated with rdh5 mutations assessed using adaptive optics scanning laser ophthalmoscopy.2014

    • Author(s)
      Muraoka, Y., Tsujikawa, A., Kumagai, K., Akagi-Makiyama, Y., Ooto, S., Hangai, M., Ogino, K., Gotoh, N., Oishi, A. & Yoshimura, N.
    • Journal Title

      Am J Ophthalmol

      Volume: 157 Issue: 3 Pages: 558-570

    • DOI

      10.1016/j.ajo.2013.10.021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and spatial distribution of cystoid spaces in retinitis pigmentosa: Investigation with spectral domain optical coherence tomography.2014

    • Author(s)
      Makiyama, Y., Oishi, A., Otani, A., Ogino, K., Nakagawa, S., Kurimoto, M. & Yoshimura, N.
    • Journal Title

      Retina

      Volume: 34 Issue: 5 Pages: 981-988

    • DOI

      10.1097/iae.0000000000000010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamina cribrosa defects and optic disc morphology in primary open angle glaucoma with high myopia.2014

    • Author(s)
      Kimura, Y., Akagi, T., Hangai, M., Takayama, K., Hasegawa, T., Suda, K., Yoshikawa, M., Yamada, H., Nakanishi, H., Unoki, N., Ikeda, H. O. & Yoshimura, N.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: e115313-e115313

    • DOI

      10.1371/journal.pone.0115313

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tomographic comparison of cone-rod and rod-cone retinal dystrophies.2014

    • Author(s)
      Inui, E., Oishi, A., Oishi, M., Ogino, K., Makiyama, Y., Gotoh, N., Kurimoto, M. & Yoshimura, N.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 252 Issue: 7 Pages: 1065-1069

    • DOI

      10.1007/s00417-014-2570-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel vcp modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa.2014

    • Author(s)
      Ikeda, H. O., Sasaoka, N., Koike, M., Nakano, N., Muraoka, Y., Toda, Y., Fuchigami, T., Shudo, T., Iwata, A., Hori, S., Yoshimura, N. & Kakizuka, A.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 5970-5970

    • DOI

      10.1038/srep05970

    • NAID

      120005464816

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of optic disc morphology of optic nerve atrophy between compressive optic neuropathy and glaucomatous optic neuropathy.2014

    • Author(s)
      Hata, M., Miyamoto, K., Oishi, A., Makiyama, Y., Gotoh, N., Kimura, Y., Akagi, T. & Yoshimura, N.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 11 Pages: e112403-e112403

    • DOI

      10.1371/journal.pone.0112403

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging2014

    • Author(s)
      Hideyuki Yaginuma, Shinnosuke Kawai, Kazuhito V. Tabata, Keisuke Tomiyama, Akira Kakizuka, Tamiki Komatsuzaki, Hiroyuki Noji, and Hiromi Imamura
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6522-6522

    • DOI

      10.1038/srep06522

    • NAID

      120005575159

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measurement of retinal nerve fiber layer thickness in eyes with optic disc swelling by using scanning laser polarimetry and optical coherence tomography.2014

    • Author(s)
      Hata M, Miyamoto K, Oishi A, Kimura Y, Nakagawa S, Horii T, Yoshimura N.
    • Journal Title

      Clin Ophthalmol

      Volume: 8 Pages: 105-111

    • DOI

      10.2147/opth.s46769

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy2013

    • Author(s)
      Takayama K, Ooto S, Hangai M, Ueda-Arakawa N, Yoshida S, Akagi T, Ikeda HO, Nonaka A, Hanebuchi M, Inoue T, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 155(5) Issue: 5 Pages: 870-81

    • DOI

      10.1016/j.ajo.2012.11.016

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripapillary scleral deformation and retinal nerve fiber damage in high myopia assessed with swept-source optical coherence tomography.2013

    • Author(s)
      Akagi T, Hangai M, Kimura Y, Ikeda HO, Nonaka A, Matsumoto A, Akiba M, Yoshimura N.
    • Journal Title

      Am J Ophthalmol.

      Volume: 155 Issue: 5 Pages: 927-936

    • DOI

      10.1016/j.ajo.2012.12.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripapillary scleral deformation and retinal nerve fiber damage in high myopia assessed with swept-source optical coherence tomography.2013

    • Author(s)
      Nakano N, Hangai M, Noma H, Nukada M, Mori S, Morooka S, Takayama K, Kimura Y, Ikeda HO, Akagi T, Yoshimura N.
    • Journal Title

      Am J Ophthalmol.

      Volume: 155 Issue: 3 Pages: 511-523

    • DOI

      10.1016/j.ajo.2013.04.028

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional imaging of lamina cribrosa defects in glaucoma using swept-source optical coherence tomography.2013

    • Author(s)
      Takayama K, Hangai M, Kimura Y, Morooka S, Nukada M, Akagi T, Ikeda HO, Matsumoto A, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Issue: 7 Pages: 4798-807

    • DOI

      10.1167/iovs.13-11677

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular Structure Parameters as an Automated Indicator of Paracentral Scotoma in Early Glaucoma.2013

    • Author(s)
      Kimura Y, Hangai M, Matsumoto A, Akagi T, Ikeda HO, Ohkubo S, Sugiyama K, Iwase A, Araie M, Yoshimura N.
    • Journal Title

      Am J Ophthalmol.

      Volume: 156 Issue: 5 Pages: 907-917

    • DOI

      10.1016/j.ajo.2013.06.029

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Image quality improvement in adaptive optics scanning laser ophthalmoscopy assisted capillary visualization using b-spline-based elastic image registration.2013

    • Author(s)
      Uji A, Ooto S, Hangai M, Arichika S, Yoshimura N.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 11 Pages: e80106-e80106

    • DOI

      10.1371/journal.pone.0080106

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography.2012

    • Author(s)
      Muraoka Y et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 4 Pages: e36135-e36135

    • DOI

      10.1371/journal.pone.0036135

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel method to detect local ganglion cell loss in early glaucoma using spectral-domain optical coherence tomography.2012

    • Author(s)
      Takayama K, Hangai M, Durbin M, Nakano N, Morooka S, Akagi T, Ikeda HO, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53 Issue: 11 Pages: 6904-13

    • DOI

      10.1167/iovs.12-10210

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 網膜色素変性に対する 新規神経保護治療2014

    • Author(s)
      池田華子
    • Organizer
      62回 医療相談会
    • Place of Presentation
      神戸勤労会館
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 網膜虚血再灌流ラットモデルにおけるvalosin-containing protein modifierの神経保護効果の検討2014

    • Author(s)
      畑匡侑、池田華子、飯田悠人、吉川宗光、長谷川智子、村岡勇貴、垣塚彰、吉村長久
    • Organizer
      53回日本網膜硝子体学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-11-28 – 2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 未来の神経保護治療2014

    • Author(s)
      池田華子
    • Organizer
      25回 日本緑内障学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] VCP ATPase阻害剤による 新規神経保護治療2014

    • Author(s)
      池田華子
    • Organizer
      34回日本眼薬理学会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Neuroprotective effects of a VCP modulator on rat models of ischemia and reperfusion-induced retinal degeneration2014

    • Author(s)
      Masayuki Hata, Hanako O. Ikeda, Tomoko Hasegawa, Noriko Nakano, Yuki Muraoka, Akira Kakizuka, Nagahisa Yoshimura
    • Organizer
      ARVO2014
    • Place of Presentation
      Orland, Fla., USA
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neuroprotective effect of a valosin-containing-protein ATPase inhibitor on late-stage retinal degeneration in a mouse model.2014

    • Author(s)
      Tomoko Hasegawa, Hanako O. Ikeda, Yuki Muraoka1,Akira Kakizuka,Nagahisa Yoshimura.
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Japan, Tokyo
    • Year and Date
      2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] VCP阻害剤による網膜神経保護効果のメカニズム2013

    • Author(s)
      池田華子、中野紀子、村岡勇貴、長谷川智子、垣塚彰、吉村長久
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Presentation] VCP 阻害剤によるCCR2欠損マウスのドルーゼン抑制効果の検討2013

    • Author(s)
      村岡勇貴、池田華子、中野紀子、長谷川智子、垣塚彰、吉村長久
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Presentation] VCP阻害剤によるグラスト欠損マウスにおける 神経保護効果の検討2013

    • Author(s)
      中野紀子、池田華子、村岡勇貴、板谷正紀、垣塚彰、吉村長久
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Presentation] 網膜変性モデルマウスの光干渉断層計、網膜電図、組織所見の比較2013

    • Author(s)
      長谷川智子、池田華子、中野紀子、村岡勇貴、吉村長久
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Presentation] VCP阻害剤による新規神経保護治療2013

    • Author(s)
      池田華子
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Presentation] Neuroprotective effect of valosin-containing protein inhibitors on mice models of glaucoma2013

    • Author(s)
      Hanako Ohashi Ikeda、Noriko Nakano,Yuki Muraoka, Masanori Hangai, Akira Kakizuka, Nagahisa Yoshimura
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Novel Valosin-Containing Protein Inhibitor Suppresses Photoreceptor Degeneration in a Rabbit Model of Retinitis Pigmentosa2013

    • Author(s)
      Yuki Muraoka,1 Hanako Ohashi Ikeda,1 Noriko Nakano,1 Tomoko Hasegawa,1 Kondo Mineo,2 Hiroko Terasaki,3 Akira Kakizuka,4 Nagahisa Yoshimura1
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optical coherence tomography, electroretinography, and histological analysis of mouse models for retinal degeneration2013

    • Author(s)
      Tomoko HasegawaHanako Ohashi Ikeda,1 Noriko Nakano,1 Yuki Muraoka,1 Akira Kakizuka,4 Nagahisa Yoshimura1
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学眼科学教室、網膜神経保護治療プロジェクト

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~ganka/html/mshp1.html

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 眼疾患処置薬2015

    • Inventor(s)
      吉村長久 他3名
    • Industrial Property Rights Holder
      吉村長久 他3名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-02-26
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 虚血性眼疾患の処置および/または予防用の医薬組成物2015

    • Inventor(s)
      垣塚彰、池田華子、吉村長久, 他1名
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Filing Date
      2015-02-26
    • Description
      特願2014-038457
    • Related Report
      Products Report
    • Overseas
  • [Patent(Industrial Property Rights)] 眼疾患治療薬2014

    • Inventor(s)
      池田華子、吉村長久他2名
    • Industrial Property Rights Holder
      池田華子、吉村長久他2名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-28
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 眼疾患処置薬2014

    • Inventor(s)
      池田華子、吉村長久他5名
    • Industrial Property Rights Holder
      池田華子、吉村長久他5名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-19
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 眼疾患処置薬2014

    • Inventor(s)
      垣塚彰、池田華子、吉村長久, 他1名
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-19
    • Acquisition Date
      2017-12-22
    • Description
      米国 : 9782120 日本特許登録 : 6261011 2017/10/10
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 眼疾患処置薬2011

    • Inventor(s)
      垣塚彰、堀清次、池田華子、吉村長久, 他3名
    • Industrial Property Rights Holder
      国立大学法人京都大学、他一社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-09-30
    • Acquisition Date
      2015-10-16
    • Description
      イギリス : 2623494 フランス : 2623494 米国 : 920619
    • Related Report
      Products Report

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Published: 2012-11-27   Modified: 2019-07-29  

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