Studies on Homeo-dynamics with Embodied cultured and Artificial Neural Circuits

• Project/Area Number: 24300080
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Perception information processing/Intelligent robotics
• Research Institution: The University of Tokyo
• Principal Investigator: IKEGAMI Takashi 東京大学, 総合文化研究科, 教授 (10211715)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Hirokazu 東京大学, 先端科学技術研究センター, 講師 (90361518)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 自律ロボット / 培養神経回路 / 学習 / 可塑性 / スパイクニューロン / シミュレーション / 培養神経細胞 / 自律運動ロボット / ヘッブ学習 / ホメオスタシス / サイバネティクス / 同期 / 神経発火 / CMOS電極アレイ / 移送エントロピー / izhikevich神経細胞

Outline of Final Research Achievements

We designed a feedback loop system between a robot and a neural circuit, where a (either cultured or artificial) neural circuit controls the robot's behavior and the information from the environment will be feedback onto the neural circuit. By studying this iteration of stimulus and behavior of the feedback loop system, i) we characterized the development of cultured neural circuit by the transfer entropy, and we discovered that ii) a cultured neural circuit can create a structure by this feedback looping and iii) this pattern obeys a new principle of "learning by avoiding stimulus" at the network level.

Research Products

• [Journal Article] Spike-Timing Dependent Plasticity Induces Learning by Stimulation Avoidance in Spiking Neural Networks (2015)
  • Author(s): Lana Sinapayen, Atsushi Masumori, Nathaniel Virgo, and Takashi Ikegami
  • Journal Title: the proceedings of ECAL2015 Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Learning by Stimulation-Avoidance Principle on Embodied Cultured Neuronal Cells. (2015)
  • Author(s): Atsushi Masumori, Norihiro Maruyama, Julien Hubert, Takeshi Mita, Douglas Bakkum, Hirokazu Takahashi and Takashi Ikegami
  • Journal Title: the proceedings of ECAL2015 Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Robotic Approach to Understanding the Role and the Mechanism of Vicarious Trial-And-Error in a T-Maze Task (2014)
  • Author(s): Eiko Matsuda, Julien Hubart and Takashi Ikegami
  • Journal Title: PLoS ONE Volume: 9 Issue: 7 Pages: 0102708-0102708
  • DOI: 10.1371/journal.pone.0102708
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Investigating Extended Embodiment Using a Computational Model and Human Experimentation (2013)
  • Author(s): Sato, Y., Iizuka, H., Ikegami, T.
  • Journal Title: Constructivist Foundations Volume: 9(1) Pages: 73-84
  • Peer Reviewed
• [Journal Article] The Self-moving Oil Droplet as a Homeostat (2013)
  • Author(s): Ikegami, T.
  • Journal Title: Constructivist Foundations Volume: 9(1) Pages: 114-114
  • Peer Reviewed
• [Journal Article] Analysis of neuronal cells of dissociated primary culture on high-density CMOS electrode array (2013)
  • Author(s): Matsuda, E., Mita, T., Hubert, J., Bakkum, Frey, D,U., Hierlemann, A., Takahashi, H., Ikegami, T.
  • Journal Title: Proceedings of 35th International Conference of the IEEE Engineering in Medicine and Biology Society Volume: - Pages: 1045-1048
  • Peer Reviewed
• [Journal Article] Hebbian Learning in a Multimodal Environment", In Liò, P. et a（l. eds.） (2013)
  • Author(s): Hubert, J., Matsuda, E., Ikegami, T.
  • Journal Title: Advances in Artificial Life, ECAL 2013: Proceedings of the Twelfth European Conference on the Synthesis and Simulation of Living Systems Volume: - Pages: 698-705
  • Peer Reviewed
• [Journal Article] Multiple time scales observed in spontaneously evolved neurons on high-density cmos electrode array (2013)
  • Author(s): Matsuda, E., Mita, T., Hubert, J., Oka, M., Bakkum, D., Frey, D,U., Takahashi, H., Ikegami, T.
  • Journal Title: Proceedings of the Twelfth European Conference on the Synthesis and Simulation of Living Systems Volume: - Pages: 1075-1082
  • Peer Reviewed
• [Journal Article] 神経工学の潮流 (2013)
  • Author(s): 高橋宏知, 神保泰彦
  • Journal Title: 電気学会論文誌C電子情報システム部門誌 Volume: 133(3) Pages: 544-549
  • NAID: 10031155345
  • Peer Reviewed
• [Journal Article] Dissociated neuronal culture expressing ionotropic odorant receptors as a hybrid odorant biosensor -proof-of-concept study- (2012)
  • Author(s): Norio Tanada, Takeshi Sakurai, Hidefumi Mitsuno, Douglas J. Bakkum, Ryohei Kanzaki, Hirokazu Takahashi
  • Journal Title: Analyst Volume: 137(15) Pages: 3452-3458
  • Peer Reviewed
• [Journal Article] "Capabilities of a High-Density CMOS Microelectrode Array to Identify, Record, and Stimulate Individual Neurons in Cultured Networks. (2012)
  • Author(s): Douglas J Bakkum, Urs Frey, Jan Mueller, Michele Fiscella, Branka Roscic, Hirokazu Takahashi, Andreas Hierlemann
  • Journal Title: Proceedings of the 8th International Meeting on Substrate-Integrated Micro Electrode Arrays Pages: 206-207
  • Peer Reviewed
• [Presentation] Multiple Time Scales Observed in Spontaneously Evolved Neurons on High-density CMOS Electrode Array (2015)
  • Author(s): Eiko Matsuda
  • Organizer: 2nd NeuroCMOS Workshop
  • Place of Presentation: 兵庫県神戸市、RIKEN Kobe Institute
  • Year and Date: 2015-01-20
• [Presentation] Spatio-Temporal Analysis of Activity in an Embodied Cultured Neural Network (2015)
  • Author(s): Atsushi Masumori
  • Organizer: 2nd NeuroCMOS Workshop
  • Place of Presentation: 兵庫県神戸市、RIKEN Kobe Institute
  • Year and Date: 2015-01-20
• [Presentation] IIT as a Measure for a Pseudo-Conscious State of a Cultured Neural Network (2015)
  • Author(s): Takashi Ikegami
  • Organizer: 2nd NeuroCMOS Workshop
  • Place of Presentation: 兵庫県神戸市、RIKEN Kobe Institute
  • Year and Date: 2015-01-20
• [Presentation] Towards Computation with Neuronal Culture (2015)
  • Author(s): Hirokazu Takahashi
  • Organizer: 2nd NeuroCMOS Workshop
  • Place of Presentation: 兵庫県神戸市、RIKEN Kobe Institute
  • Year and Date: 2015-01-20
• [Presentation] Designing a Robotic Platform Controlled by Cultured Neural Cells. (2014)
  • Author(s): Maruyama, N., Masumori, A., Hubert, J., Mita, T., Bakkum, D., Takahashi, H. and Ikegami, T
  • Organizer: ALIFE14
  • Place of Presentation: NewYork, USA
  • Year and Date: 2014-07-30 – 2014-08-02
• [Presentation] 身体化された培養神経回路網䛾活動䛾時空間解析 (2014)
  • Author(s): 升森敦士 丸山典宏 三田毅 Urs Frey Douglas Bakkum 高橋宏知 池上高志
  • Organizer: 日本人工知能学会
  • Place of Presentation: 愛媛県松山市、ひめぎんホール
  • Year and Date: 2014-05-12 – 2014-05-15
• [Presentation] 高密度電極アレイを用いた培養神経細胞による実環境ロボットの 構築 (2014)
  • Author(s): 丸山典宏 升森敦士 池上高志
  • Organizer: 日本人工知能学会
  • Place of Presentation: 愛媛県松山市、ひめぎんホール
  • Year and Date: 2014-05-12 – 2014-05-15
• [Presentation] VTE and consciousness (2013)
  • Author(s): 池上高志
  • Organizer: Workshop on Language and Cognition in Embodied Agents
  • Place of Presentation: Institute of Cognitive Sciences and Technologies, Roma, Italy
• [Presentation] homunculus (workshop title) (2013)
  • Author(s): 池上高志
  • Organizer: ICT&ART CONNECT 2013
  • Place of Presentation: Center for Digital Technology, Brussels, Belgium
  • Invited
• [Presentation] Massive Data Flows (2013)
  • Author(s): 池上高志
  • Organizer: MDFワークショップ
  • Place of Presentation: Institute of Complex Systems, Paris, France
• [Presentation] Analysis of Neuronal Cells by Dissociated Primary Culture on High-Density CMOS Electrode Array (2013)
  • Author(s): 池上高志
  • Organizer: 35th Annual International IEEE EMBS Conference
  • Place of Presentation: 大阪国際コンベンションセンター, 大阪市, 大阪府
• [Presentation] Frequency Conversion using Sub-Threshold Dynamics in Artificial Spiking Neurons (2013)
  • Author(s): Julien Hubert and Takashi Ikegami
  • Organizer: 7th International Workshop on Natural Computing, IWNC 20-22
  • Place of Presentation: 東京大学(東京)
• [Presentation] Capability of an 11,011-electrode CMOS array to study action potential propagation plasticity (2012)
  • Author(s): Douglas J Bakkum, Urs Frey, Jan Mueller, Michele Fiscella, Branka Roscic, Hirokazu Takahashi, Andreas Hierlemann
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-13
• [Presentation] 高密度CMOSアレイ上培養神経細胞の細胞体位置の推定 (2012)
  • Author(s): 三田毅, 石原裕也, Douglas Bakkum, Urs Frey, Andreas Hierlemann, 神崎亮平, 高橋宏知
  • Organizer: 第27回生体生理工学シンポジウム講演
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-09-18
• [Presentation] 高密度CMOSアレイの観測電位と神経細胞の生理学的特性 (2012)
  • Author(s): 三田毅, D. Bakkum, 棚田法男, U. Frey, A. Hierlemann, 神崎亮平, 高橋宏知
  • Organizer: 平成24年電気学会電子・情報・システム部門人会
  • Place of Presentation: 弘前大学(弘前市)
  • Year and Date: 2012-09-05
• [Presentation] ロボット実験による vicarious trial-and-error (VTE)の役割の解析 (2012)
  • Author(s): 松田英子, Hubert, J., 池上高志
  • Organizer: 2012年度人工知能学会全国大会(第26回)
  • Place of Presentation: 山口教育会館(山口市)
• [Presentation] A Robotic Approach to Understand the Mechanism and the Role of Vicarious Trial-and-Error in a T-Maze Task (2012)
  • Author(s): Eiko Matsuda, Hubert Julien, Takashi Ikegami
  • Organizer: Summer School in Cognitive Sciences 2012,
  • Place of Presentation: Montreal, Canada
• [Presentation] Information integration of multimodal systems (2012)
  • Author(s): 松田英子
  • Organizer: Ikegami Lab. Summer Workshop 2012 - Artificial Minds and Real Brains
  • Place of Presentation: 北海道大学(札幌)
• [Presentation] 理系の学生に見られる共感覚者の割合とその内容 (2012)
  • Author(s): 松田英子, Tom Froese, 北村英哉, 開一夫
  • Organizer: 日本認知科学会第9回大会
  • Place of Presentation: 仙台国際センター(仙台市)