Role of activity-dependent gene Arc in synaptic plasticity
Project/Area Number |
24300117
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | Kyoto University (2013-2014) The University of Tokyo (2012) |
Principal Investigator |
OKUNO Hiroyuki 京都大学, 医学(系)研究科(研究院), 特定准教授 (80272417)
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Co-Investigator(Renkei-kenkyūsha) |
BITO Haruhiko 東京大学, 大学院医学系研究科, 教授 (00291964)
SAKIMURA Kenji 新潟大学, 脳研究所, 教授 (40162325)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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Keywords | シナプス / 長期記憶 / 海馬 / Arc / CaMKII / 活動依存的遺伝子発現 / 可塑性 / 神経科学 / 脳・神経 / 遺伝子 / シグナル伝達 |
Outline of Final Research Achievements |
Long-term synaptic plasticity and memory formation require activity-dependent gene expression. However, it remains unknown how such activity-induced gene products are targeted to proper cellular compartments including synapses. In the present study, we investigated the targeting of the memory related-protein Arc from the soma to the synapses, and elucidated a novel “inverse” synaptic tagging mechanism that enables Arc to specifically target the un-potentiated synapses. The findings provide new mechanistic insights into how the contrast between strong and weak synapses is maintained during long-term synaptic plasticity. We further identified the CREB coactivator CRTC1 as a critical factor for Arc expression as well as memory function.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Neuromodulatory effect of Gαs- or Gαq-coupled GPCR on NMDAR selectively activates the NMDAR/Ca2+/calcineurin/CREB-regulated transcriptional coactivator 1 (CRTC1) pathway to effectively induce Bdnf expression in neurons.2015
Author(s)
Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takamori H, Okuno H, Bito H, Tsuda M.
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Journal Title
J Neurosci.
Volume: 35
Issue: 14
Pages: 5606-5624
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory2014
Author(s)
Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H
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Journal Title
Neuron
Volume: 84
Issue: 1
Pages: 92-106
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Whole-brain mapping of behaviourally induced neural activation in mice.2014
Author(s)
Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM
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Journal Title
Brain Struct Funct.
Volume: E-pub
Issue: 4
Pages: 2043-2057
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Regulation of synaptic and cognitive function through the activity-dependent gene Arc/Arg3.1.2014
Author(s)
Okuno, H., Endo, T., Kim, R., Ishii, Y., Minatohara, K., Araki, A., Sakimura, K., Bito, H.
Organizer
第36回日本生物学的精神医学会・第57回日本神経化学学会
Place of Presentation
奈良
Year and Date
2014-09-29
Related Report
Invited
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[Presentation] Visualization of an active ensemble of cortical neurons in vivo using a novel activity-dependent promoter E-SARE.2012
Author(s)
Kawashimna T, Kitamura K, Ohki K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Bito H.
Organizer
42th Annual Meeting of Soc for Neurosci,
Place of Presentation
New Orleans, USA
Year and Date
2012-10-15
Related Report
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