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Dynamic neural representation of self-actions and others' actions

Research Project

Project/Area Number 24300125
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionKansai Medical University

Principal Investigator

ISODA MASAKI  関西医科大学, 医学部, 准教授 (90466029)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords神経生理学 / 自己 / 他者 / 霊長類 / 社会的認知機能 / 動作 / 遺伝子 / 前頭葉内側皮質 / 動物 / 生理学 / 神経科学 / 社会文脈依存的情報表現 / サル / 単一神経細胞活動記録 / 行動モニタリング / 観察学習
Outline of Final Research Achievements

This study investigated dynamic representational aspects of self-actions and others' actions in the macaque brain. In the medial frontal lobe of the cerebral cortex, the neuronal representation of self-actions was strongly influenced by the presence or absence of other individuals ('social context'). Moreover, the neuronal representation of others' actions was affected not only by such social contexts, but also by the appropriateness of others' actions. Furthermore, there was a significant paucity of other-action representation in an animal displaying a social monitoring impairment. These findings may provide important insights into the pathophysiological mechanism underlying atypical recognition of the self and others exhibited by people suffering from mental illness.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (33 results)

All 2015 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (22 results) (of which Invited: 7 results)

  • [Journal Article] 自己の動作と他者の動作を区別する神経回路2015

    • Author(s)
      磯田 昌岐
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 147-150

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 社会的階層と集団サイズ2015

    • Author(s)
      則武 厚,磯田 昌岐
    • Journal Title

      生体の科学

      Volume: 66 Pages: 72-75

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 社会的認知機能の生理学的理解―サルを用いた研究から―2015

    • Author(s)
      磯田 昌岐
    • Journal Title

      神経心理学

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Toward a better understanding of social learning, social deciding, and other-regarding preferences2014

    • Author(s)
      Steve Chang, Masaki Isoda
    • Journal Title

      Frontiers in Neuroscience

      Volume: 8

    • DOI

      10.3389/fnins.2014.00362

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] What makes the dorsomedial frontal cortex active during reading the mental states of others?2013

    • Author(s)
      Masaki Isoda, Atsushi Noritake
    • Journal Title

      Frontiers in Neuroscience

      Volume: 7

    • DOI

      10.3389/fnins.2013.00232

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological animal models of tic disorders2013

    • Author(s)
      Kevin McCairn, Masaki Isoda
    • Journal Title

      International Review of Neurobiology

      Volume: 112 Pages: 179-209

    • DOI

      10.1016/b978-0-12-411546-0.00007-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マカクザルを用いた社会脳研究の最近の進歩2013

    • Author(s)
      磯田昌岐
    • Journal Title

      脳と神経

      Volume: 65 Pages: 679-686

    • NAID

      40019703449

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 眼球運動を手がかりとして認知機能の脳内機構を探る2013

    • Author(s)
      磯田昌岐
    • Journal Title

      神経眼科

      Volume: 30 Pages: 9-16

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Deep brain stimulation reduces tic-related neural activity via temporal locking with stimulus pulses2013

    • Author(s)
      Kevin McCairn, Atsushi Iriki, Masaki Isoda
    • Journal Title

      Journal of Neuroscience

      Volume: 33 Issue: 15 Pages: 6581-6593

    • DOI

      10.1523/jneurosci.4874-12.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global dysrhythmia of cerebro-basal ganglia-cerebellar networks underlies motor tics following striatal disinhibition2013

    • Author(s)
      Kevin W McCairn
    • Journal Title

      Journal of Neuroscience

      Volume: 33 Issue: 2 Pages: 697-708

    • DOI

      10.1523/jneurosci.4018-12.2013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social error monitoring in macaque frontal cortex2012

    • Author(s)
      Yoshida K., Iriki A.
    • Journal Title

      Nat Neurosci

      Volume: 15 Issue: 9 Pages: 1307-1312

    • DOI

      10.1038/nn.3180

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Distinct cortical and subcortical networks drive myoclonic and vocal tics in the nonhuman primate model of Tourette syndrome: A PET and electrophysiological study2014

    • Author(s)
      Kevin McCairn, Yuji Nagai, Yukiko Hori, Atsushi Iriki, Masahiko Takada, Takafumi Minamimoto, Masaki Isoda, Masayuki Matsumoto
    • Organizer
      The 44th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC (U.S.A.)
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Social reward valuation in the macaque. I. Design of a behavioral paradigm.2014

    • Author(s)
      Masaki Isoda, Atsushi Noritake
    • Organizer
      The 44th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC (U.S.A.)
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Social reward valuation in the macaque. II. Role for dorsomedial prefrontal cells.2014

    • Author(s)
      Atsushi Noritake, Masaki Isoda
    • Organizer
      The 44th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC (U.S.A.)
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 社会的認知機能の生理学的理解―サルを用いた研究から2014

    • Author(s)
      磯田 昌岐
    • Organizer
      第38回日本神経心理学会学術集会
    • Place of Presentation
      山形テルサ(山形県・山形市)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Spontaneously Emerging Parkinsonism-Cerebellar Syndrome in a Subspecies of Japanese Macaque (Macaca fuscata yakui): A Potential Analogue of Multiple System Atrophy2014

    • Author(s)
      Kevin McCairn, Yuji Nagai, Katsuo Kimura, Yasuhiro Go, Kenichi Inoue, Masaki Isoda, Takafumi Minamimoto, Masayuki Matsumoto, Masahiko Takada
    • Organizer
      The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Probing the neural code of self- and other’s actions in the macaque medial frontal cortex2014

    • Author(s)
      Masaki Isoda
    • Organizer
      The 9th FENS Forum of Neuroscience
    • Place of Presentation
      Milan (Italy)
    • Year and Date
      2014-07-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Clarifying the neuronal and genetic basis of social action monitoring using macaques2014

    • Author(s)
      Masaki Isoda
    • Organizer
      The International Neuropsychological Symposium 2014
    • Place of Presentation
      Lido di Camaiore (Italy)
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Clarifying the neural mechanisms of social action monitoring using macaques2014

    • Author(s)
      磯田昌岐
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島県鹿児島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 社会的認知機能のシステム生理学的理解2013

    • Author(s)
      磯田昌岐
    • Organizer
      第3回社会神経科学研究会(招待講演)
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Social action monitoring: from genes to physiology and behavior2013

    • Author(s)
      Masaki Isoda
    • Organizer
      International symposium on Prediction and Decision Making
    • Place of Presentation
      京都大学(京都府京都市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role for medial frontal cortex cells in social action monitoring2013

    • Author(s)
      Masaki Isoda
    • Organizer
      Symposium on Neural Circuits for Adaptive Control of Behavior
    • Place of Presentation
      ICM研究所(フランス、パリ市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Decoding a limbic-motor network contribution to the expression of obsessive-compulsive behavior in macaques2013

    • Author(s)
      Kevin McCairn, Masaki Isoda, Atsushi Iriki, Masahiko Takada, Masayuki Matsumoto
    • Organizer
      第11回世界生物学的精神医学学会国際会議
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Global dysrhythmia of cortico-basal ganglia-cerebellar networks underlie motor tics in a nonhuman primate model of Tourette syndrome2013

    • Author(s)
      Kevin McCairn, Atsushi Iriki, Masaki Isoda
    • Organizer
      第11回世界生物学的精神医学学会国際会議
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Elimination of tic-related neuronal activity by deep brain stimulation via interlocking with stimulus pulses2013

    • Author(s)
      Kevin McCairn, Atsushi Iriki, Masaki Isoda
    • Organizer
      第11回世界生物学的精神医学学会国際会議
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Decoding a limbic-motor network contribution to the expression of obsessive compulsive behavior in macaques2013

    • Author(s)
      Kevin McCairn, Masaki Isoda, Atsushi Iriki, Masahiko Takada, Masayuki Matsumoto
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Deep brain stimulation eliminates tic-related neural activity via interlocking with stimulus pulses2013

    • Author(s)
      Kevin McCairn, Atsushi Iriki, Masaki Isoda
    • Organizer
      The 16th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Developing a systems neuroscience of self and others using macaques2013

    • Author(s)
      Masaki Isoda
    • Organizer
      Third Symposium on Biology of Decision-Making
    • Place of Presentation
      ICM研究所(フランス、パリ市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Monitoring other's actions in the medial prefrontal cortex of the macaque2012

    • Author(s)
      Masaki Isoda
    • Organizer
      第3回前頭前野国際シンポジウム
    • Place of Presentation
      稲盛財団記念館(京都府)(招待講演)
    • Year and Date
      2012-11-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 眼球運動を手がかりとして認知機能の脳内機構を探る2012

    • Author(s)
      磯田昌岐
    • Organizer
      第50回日本神経眼科学会総会
    • Place of Presentation
      京都テルサ(京都府)(招待講演)
    • Year and Date
      2012-11-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Atypical agent-related activities in the medial frontal cortex of a monkey with impaired social monitoring2012

    • Author(s)
      Kyoko Yoshida
    • Organizer
      第42回北米神経科学学会大会
    • Place of Presentation
      Ernest N. Memorial Convention Center (米国ルイジアナ州)
    • Year and Date
      2012-10-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] The cerebellum contributes to basal ganglia mediated motor tics2012

    • Author(s)
      Kevin W McCairn
    • Organizer
      第35回日本神経科学学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Probing the neural correlates of self and others' actions in monkey medial frontal cortex2012

    • Author(s)
      Masaki Isoda
    • Organizer
      Mirror neurons : 20 years after the discovery
    • Place of Presentation
      百周年時計台記念館(京都府)(招待講演)
    • Year and Date
      2012-09-09
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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