Regulation of neuronal circuit development and regeneration by lysophospholipids
Project/Area Number |
24300137
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Kamiguchi Hiroyuki 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (10233933)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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Keywords | 脊髄 / 感覚神経 / 軸索ガイダンス / グリセロリン脂質 / Gタンパク質共役型受容体 / 後根神経節 / 軸索 / リゾリン脂質 / 受容体 / 成長円錐 / G蛋白質共役型受容体 / カルシウム / リゾリン脂 |
Outline of Final Research Achievements |
Lipids exhibit vast physicochemical diversity and may participate in biological processes inaccessible to protein-based mechanisms. Here we identify lyso-phosphatidyl-β-D-glucoside (LysoPtdGlc), a novel hydrophilic glycerophospholipid that is synthesised and released by radial glia in a patterned spatial distribution. LysoPtdGlc regulates the development of sensory circuits in the vertebrate spinal cord by sorting nociceptive and proprioceptive afferents at a previously unexplained axon segregation checkpoint. The G protein-coupled receptor GPR55 is a high-affinity receptor for LysoPtdGlc, and GPR55 deletion phenocopies LysoPtdGlc loss-of-function in vivo, misdirecting nociceptive axons into proprioceptive zones. This study demonstrates LysoPtdGlc/GPR55 as a crucial mediator of glia-neuron communication for axon spatial patterning and suggests a broader role for lipids in coordinating diverse biological functions.
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.2013
Author(s)
2. Fujita, A., Koinuma, S., Yasuda, S., Nagai, H., Kamiguchi, H., Wada, N., and Nakamura, T.
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Journal Title
PLoS One
Volume: 8
Issue: 11
Pages: 9593-9601
DOI
Related Report
Peer Reviewed
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