Analysis on cellular and molecular mechanism behind the depressive behavior by approaching the functional interaction between stress hormone and BDNF.
Project/Area Number |
24300139
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Kumamoto University (2014-2015) National Center of Neurology and Psychiatry (2012-2013) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
CHIBA Shuichi 武蔵野大学, 付置研究所, 助教 (00510380)
NAGATANI Miyako 聖マリアンナ医科大学, 医学部, 准教授 (20450611)
ITAMI Chiaki 埼玉医科大学, 医学部, 講師 (90392430)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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Keywords | うつ病 / BDNF / グルココルチコイド / GR / ストレス / 脳神経疾患 / 神経科学 / 細胞・組織 / 神経栄養因子 |
Outline of Final Research Achievements |
Both increased levels of glucocorticoid concentration and dysfunction of BDNF (brain-derived neurotrophic factor) have been suggested to be involved in the onset of depressive disorder. Here, to approach the cellular and molecular mechanism behind the depressive behavior, we focused on functional crosstalk between glucocorticoid and BDNF. Using dissociated cortical neurons obtained from rat brain, we found significant influence of glucocorticoid exposure on action of BDNF, including transport of BDNF protein in neurites. Furthermore, we made transgenic mouse which expresses high levels of cortical GR, low affinity glucocorticoid receptor, to approach behavioral change under the stress, as we confirmed that GR-TrkB (BDNF receptor) interaction is important for the BDNF-mediated neurotransmission.
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Report
(5 results)
Research Products
(63 results)
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[Journal Article] Impairments in brain-derived neurotrophic factor-induced glutamate release in cultured cortical neurons derived from rats with intrauterine growth retardation: possible involvement of suppression of TrkB/phospholipase C-γ activation.2014
Author(s)
Numakawa T, Matsumoto T, Ooshima Y, Chiba S, Furuta M, Izumi A, Ninomiya-Baba M, Odaka H, Hashido K, Adachi N, Kunugi H.
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Journal Title
Neurochem Res.
Volume: 39(4)
Issue: 4
Pages: 785-92
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.2014
Author(s)
Suzuki N, Numakawa T, Chou J, de Vega S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi H, Arikawa-Hirasawa E, Yamada Y, Akazawa C.
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Journal Title
FASEB J.
Volume: 28(3)
Issue: 3
Pages: 1386-97
DOI
Related Report
Peer Reviewed
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[Presentation] The mechanisms behind deficits in BDNF function after phencyclidine exposure2014
Author(s)
Adachi N, Numakawa T, Kumamaru E, Itami C, Chiba S, Iijima Y, Richards M, Katoh-Semba R, Kunugi H.
Organizer
CSHA/NGF2014 Joint Conference on Nerve Growth Factor and Related Neurotrophic Factors: Emerging Concepts, New Mechanism, Novel Technologies
Place of Presentation
Suzhou, PR China
Year and Date
2014-06-23 – 2014-06-27
Related Report
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[Presentation] MicroRNA induction by basic fibroblast growth factor in pure astroglial cultures.2014
Author(s)
Nakajima S, Numakawa T, Yamamoto N, Yoshiko O, Odaka H, Hashido K, Adachi N, Kunugi H.
Organizer
CSHA/NGF2014 Joint Conference on Nerve Growth Factor and Related Neurotrophic Factors: Emerging Concepts, New Mechanism, Novel Technologies
Place of Presentation
Suzhou, PR China
Year and Date
2014-06-23 – 2014-06-27
Related Report
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[Presentation] Teneurin-4 Positively Regulates Neural Cell Process Formation and Synaptogenesis2013
Author(s)
Nobuharu Suzuki, Tadahiro Numakawa, Joshua Chou, Susana de Vega, Chihiro Mizuniwa, Kaori Sekimoto, Naoki Adachi, Hiroshi Kunugi, Eri Arikawa-Hirasawa, Yoshihiko Yamada, and Chihiro Akazawa
Organizer
Neuro2013
Place of Presentation
京都府 京都市 国立京都国際会館
Related Report
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