A combinational analysis of brain and genetic polymorphisms in children with attention deficit/hyperactivity disorder (ADHD)
| Project/Area Number |
24300149
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fusional social brain science
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| Research Institution | University of Fukui |
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Principal Investigator |
TOMODA AKEMI 福井大学, 子どものこころの発達研究センター, 教授 (80244135)
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| Co-Investigator(Kenkyū-buntansha) |
KOSAKA Hirotaka 福井大学, 子どものこころの発達研究センター, 特命教授 (70401966)
MIZUNO Kei 独立行政法人理化学研究所, ライフサイエンス技術基盤センター, 基礎科学特別研究員 (60464616)
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| Co-Investigator(Renkei-kenkyūsha) |
YATSUGA Chiho 福井大学, 子どものこころの発達研究センター, 特命助教 (80368919)
FUJISAWA Takashi 福井大学, 子どものこころの発達研究センター, 特命助教 (90434894)
KUMAZAKI Hirokazu 福井大学, 子どものこころの発達研究センター, 特命助教 (70445336)
SHIMADA Koji 福井大学, 子どものこころの発達研究センター, 特命助教 (00711128)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 発達・教育 / 学習意欲 / ADHD / 脳画像解析 / ｆMRI / 遺伝子多型解析 / 被殻 / αｰ2Aアドレナリン受容体 / α-2Aアドレナリン受容体 / 視床 / 報酬系 / fMRI |
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| Outline of Final Research Achievements |
Attention deficit/hyperactivity disorder (ADHD) is neurobehavioral disorder characterized by inattention, hyperactivity /impulsivity and impaired reward system function, such as delay aversion, and low reward sensitivity. We evaluated brain activation with fMRI and brain volume with VBM. We found that decreased activations of the nucleus accumbens and thalamus of the ADHD patients during only the low monetary reward condition before the treatment were improved to same level as those of the healthy adolescents after the treatment. The observed improvement in brain activity was associated with improved ADHD symptom scores. In addition, a combinational analysis of brain and genetic polymorphisms in children with ADHD revealed a significant association between the left putamen GMV reduction and COMT polymorphism. These results suggest that a combinational analysis of brain and genetic polymorphisms is useful in detecting neural basis in children with ADHD.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Family based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to Autism in a Han population in northeastern China.2014
Author(s)
Liang S, Wang X, Zoua M, Wanga H, Zhoua X, Suna C, Xia W, Wu L*, Fujisawa TX, Tomoda A.
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Journal Title
J Zhejiang Univ Sci B
Volume: 15(3)
Pages: 264-271
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits.2014
Author(s)
Jung M, Kosaka H, Saito DN, Ishitobi M, Morita T, Inohara K, Asano M, Arai S, Munesue T, Tomoda A, Wada Y, Sadato N, Okazawa H, Iidaka T
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Journal Title
Mol Autism
Volume: 5
Pages: 1-11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effectiveness and tolerability of switching to aripiprazole from risperidone in subjects with Pervasive Developmental Disorders: A prospective open-label study.2013
Author(s)
Ishitobi M, Kosaka H, Takahashi T, Yatsuga C, Asano M, Tanaka Y, Ueno K, Okazaki R, Omori M, Hiratani M, Tomoda A, Wada Y.
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Journal Title
Clinical Neuropharmacology
Volume: 36
Pages: 151-156
DOI
Related Report
Peer Reviewed
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[Presentation] Assessment of gait asymmetry in children with and without ADHD: Approach using quantitative analysis.
Author(s)
Naruse H, Yatsuga C, Fujisawa TX, Kumazaki H, Mizushima S, Takiguchi S, Aoi T, Kojima M, Koizumi M, Shimada S, Tomoda A.
Organizer
International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology (Fukui2014: The Fifth International Workshop on Biomedical Imaging)（ポスター発表）
Place of Presentation
Fukui、Yours Hotel Fukui
Related Report
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[Presentation] Gait differences in children with and without ADHD, A quantitative analysis.
Author(s)
Naruse H, Yatsuga C, Fujisawa TX, Takiguchi S, Mizushima S, Aoi T, Kojima M, Koizumi M, Shimada S, Baba H, Nakai A, Tomoda A.
Organizer
2nd Asian Congress on ADHD（ポスター発表）
Place of Presentation
Tokyo、東京医科大学病院
Related Report
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[Presentation] Effects of methylphenidate on neuropsychological performance in children with ADHD using the Cambridge Neuropsychological Test Automated Battery (CANTAB).
Author(s)
Arai S, Inohara K, Fujioka T, Ishitobi M, Asano M, Kawamura K, Jung M, Wada Y, Tomoda A, Hiratani M, Matsuura N, Kosaka H.
Organizer
2nd Asian Congress on ADHD（ポスター発表）
Place of Presentation
Tokyo、東京医科大学病院
Related Report
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