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A combinational analysis of brain and genetic polymorphisms in children with attention deficit/hyperactivity disorder (ADHD)

Research Project

Project/Area Number 24300149
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Fusional social brain science
Research InstitutionUniversity of Fukui

Principal Investigator

TOMODA AKEMI  福井大学, 子どものこころの発達研究センター, 教授 (80244135)

Co-Investigator(Kenkyū-buntansha) KOSAKA Hirotaka  福井大学, 子どものこころの発達研究センター, 特命教授 (70401966)
MIZUNO Kei  独立行政法人理化学研究所, ライフサイエンス技術基盤センター, 基礎科学特別研究員 (60464616)
Co-Investigator(Renkei-kenkyūsha) YATSUGA Chiho  福井大学, 子どものこころの発達研究センター, 特命助教 (80368919)
FUJISAWA Takashi  福井大学, 子どものこころの発達研究センター, 特命助教 (90434894)
KUMAZAKI Hirokazu  福井大学, 子どものこころの発達研究センター, 特命助教 (70445336)
SHIMADA Koji  福井大学, 子どものこころの発達研究センター, 特命助教 (00711128)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords発達・教育 / 学習意欲 / ADHD / 脳画像解析 / fMRI / 遺伝子多型解析 / 被殻 / αー2Aアドレナリン受容体 / α-2Aアドレナリン受容体 / 視床 / 報酬系 / fMRI
Outline of Final Research Achievements

Attention deficit/hyperactivity disorder (ADHD) is neurobehavioral disorder characterized by inattention, hyperactivity /impulsivity and impaired reward system function, such as delay aversion, and low reward sensitivity. We evaluated brain activation with fMRI and brain volume with VBM. We found that decreased activations of the nucleus accumbens and thalamus of the ADHD patients during only the low monetary reward condition before the treatment were improved to same level as those of the healthy adolescents after the treatment. The observed improvement in brain activity was associated with improved ADHD symptom scores. In addition, a combinational analysis of brain and genetic polymorphisms in children with ADHD revealed a significant association between the left putamen GMV reduction and COMT polymorphism. These results suggest that a combinational analysis of brain and genetic polymorphisms is useful in detecting neural basis in children with ADHD.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (46 results)

All 2015 2014 2013 2012 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Open Access: 7 results) Presentation (27 results) (of which Invited: 9 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Visual attention for social information and salivary oxytocin levels in preschool children with autism spectrum disorders: An eye-tracking study.2015

    • Author(s)
      Fujisawa TX, Tanaka S, Saito DN, Kosaka H, Tomoda A*.
    • Journal Title

      Front Neurosci

      Volume: 8 Pages: 295-295

    • DOI

      10.3389/fnins.2014.00295

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex differences in cognitive and symptom profiles in children with high functioning Autism Spectrum Disorders.2015

    • Author(s)
      Kumazaki H*, Muramatsu T, Kosaka H, Fujisawa TX, Iwata K, Tomoda A, Tsuchiya K, Mimura M.
    • Journal Title

      Res Autism Spectr Disord,

      Volume: 13-14 Pages: 1-7

    • DOI

      10.1016/j.rasd.2014.12.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risperidone-associated urinary incontinence in patients with autistic disorder with mental retardation.2014

    • Author(s)
      Kumazaki H*, Watanabe K, Imasaka Y, Iwata K, Tomoda A, Mimura M.
    • Journal Title

      J Clin Psychopharmacol,

      Volume: 34(5) Issue: 5 Pages: 624-6

    • DOI

      10.1097/jcp.0000000000000197

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Family based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to Autism in a Han population in northeastern China.2014

    • Author(s)
      Liang S, Wang X, Zoua M, Wanga H, Zhoua X, Suna C, Xia W, Wu L*, Fujisawa TX, Tomoda A.
    • Journal Title

      J Zhejiang Univ Sci B

      Volume: 15(3) Issue: 3 Pages: 264-71

    • DOI

      10.1631/jzus.b1300133

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits.2014

    • Author(s)
      Jung M, Kosaka H, Saito DN, Ishitobi M, Morita T, Inohara K, Asano M, Arai S, Munesue T, Tomoda A, Wada Y, Sadato N, Okazawa H, Iidaka T
    • Journal Title

      Molecular Autism

      Volume: 5 Issue: 1 Pages: 1-11

    • DOI

      10.1186/2040-2392-5-35

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] No association between catechol-o-methyltransferase (COMT) genotype and attention deficit hyperactivity disorder (ADHD) in Japanese children2013

    • Author(s)
      Yatsuga C, Toyohisa D, Fujisawa TX, Nishitani S, Shinohara K, Matsuura N, Ikeda S, Muramatsu M, Hamada A, Tomoda A
    • Journal Title

      Brain & Dev.

      Volume: S0387-7604(13) Issue: 7 Pages: 00258-1

    • DOI

      10.1016/j.braindev.2013.08.006

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osmotic release oral system-methylphenidate improves neural activity during low reward processing in children and adolescents with attention-deficit/hyperactivity disorder.2013

    • Author(s)
      Mizuno K, Yoneda T, Komi M, Hirai T, Watanabe Y, Tomoda A.
    • Journal Title

      NeuroImage: Clinical

      Volume: 2 Pages: 366-376

    • DOI

      10.1016/j.nicl.2013.03.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness and tolerability of switching to aripiprazole from risperidone in subjects with Pervasive Developmental Disorders: A prospective open-label study.2013

    • Author(s)
      Ishitobi M, Kosaka H, Takahashi T, Yatsuga C, Asano M, Tanaka Y, Ueno K, Okazaki R, Omori M, Hiratani M, Tomoda A, Wada Y.
    • Journal Title

      Clinical Neuropharmacology

      Volume: 36 Issue: 5 Pages: 151-156

    • DOI

      10.1097/wnf.0b013e3182a31ec0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children2013

    • Author(s)
      Minako Kawabata, Taro Ueno, Jun Tomita, Junko Kawatani, Akemi Tomoda, Shoen Kume and Kazuhiko Kume
    • Journal Title

      BMC Psychiatry

      Volume: 13 Issue: 1 Pages: 281-210

    • DOI

      10.1186/1471-244x-13-281

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osmotic release oral system-methylphenidate improves neural activity during lowreward processing in children and adolescents with attention-deficit/hyperactivitydisorder.2013

    • Author(s)
      Mizuno K, Yoneda T, Komi M, Hirai T, Watanabe Y、Tomoda A.
    • Journal Title

      Neurolmage:Clinical

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No interaction between serotonin transporter gene (5-httlpr) polymorphism and adversity on depression among Japanese children and adolescents2013

    • Author(s)
      Akemi Tomoda
    • Journal Title

      BMC Psychiatry

      Volume: 13 Issue: 1 Pages: 134-143

    • DOI

      10.1186/1471-244x-13-134

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term oxytocin administration improves social behaviors in a girl with autistic disorder2012

    • Author(s)
      Kosaka H et al.,
    • Journal Title

      BMC Psychiatry

      Volume: 12(1) Issue: 1 Pages: 110-110

    • DOI

      10.1186/1471-244x-12-110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 児童期および青年期の注意欠如・多動性障害(ADHD)における薬物療法の個別化と最適化.2012

    • Author(s)
      Coghil D, 林隆,氏家武,友田明美,清田晃生,原田謙,山下洋.
    • Journal Title

      小児科臨床

      Volume: 65 Pages: 131-142

    • Related Report
      2012 Annual Research Report
  • [Presentation] ADHD児とASD児における感覚の比較.2014

    • Author(s)
      野路恵理香, 熊崎博一,新井清義,滝口慎一郎,藤澤隆史,小坂浩隆,平谷美智夫,友田明美
    • Organizer
      第55回日本児童青年精神医学会
    • Place of Presentation
      浜松,アクトシティ浜松
    • Year and Date
      2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] AD/HDを脳画像で観る~薬剤導入による脳機能変化~2013

    • Author(s)
      友田明美
    • Organizer
      第4回日本ADHD学会シンポジウム「エビデンスに基づくAD/HDの治療戦略」
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2013-03-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] ADHD薬物治療の効果判定における日本語版精密注意集中力検査(ATA)の有用性2013

    • Author(s)
      滝口慎一郎,磨井明奈,太田千里,藤岡徹,山崎未花,ハツ賀千穂,平谷美智夫, 友田明美.
    • Organizer
      第4回日本ADHD学会
    • Place of Presentation
      東京都
    • Year and Date
      2013-03-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] ADHDの診断と治療効果を画像で知る2013

    • Author(s)
      友田明美
    • Organizer
      久留米発達障害治療研究会
    • Place of Presentation
      久留米市(招待講演)
    • Year and Date
      2013-03-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] こころを脳画像で観る~薬剤導入による脳機能変化~2012

    • Author(s)
      友田明美
    • Organizer
      熊本大学生命科学研究部創薬シンポジウム「脳を視る、こころを観る」
    • Place of Presentation
      熊本市(招待講演)
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] ADHD薬物治療の効果判定における日本語版精密注意集中力検査(ATA)の有用性2012

    • Author(s)
      滝口慎一郎,磨井明奈,太田千里,藤岡徹,山崎未花,ハツ賀千穂,平谷美智夫, 友田明美.
    • Organizer
      第108回日本小児精神神経学会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-11-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] Brain activity involved in reward sensitivity in pediatric ADHD before and after MPH treatment.2012

    • Author(s)
      Tomoda A.
    • Organizer
      1st Asian congress on ADHD
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2012-11-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Usefulness of Japanese version of Advanced Test of Attention to evaluate effectiveness for ADHD treatment.2012

    • Author(s)
      Takiguchi S, Yatsuga C, Yamazaki M, Hiratani M, Tomoda A.
    • Organizer
      1st Asian congress on ADHD
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-11-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Catechol-O-methyltransferase (COMT) gene phenotype in Japanese children withADHD.2012

    • Author(s)
      Yatsuga C, Matsuura N, Tomoda A.
    • Organizer
      1st Asian congress on ADHD
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-11-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Preliminary evidence for neurobiological and behavioral consequences of exposure to childhood maltreatment on regional brain development.2012

    • Author(s)
      Tomoda A.
    • Organizer
      ASCAPAP 2012 Congress (アジア児童青年精神医学会)
    • Place of Presentation
      Paris, France(招待講演)
    • Year and Date
      2012-07-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Abnormal brain development in maltreated children.2012

    • Author(s)
      Tomoda A
    • Organizer
      20th World International Association for Child and Adolescent Psychiatry and Allied Professions (IACAPAP) 2012 Congress (第20回国際児童青年精神医学会議)
    • Place of Presentation
      Paris, France(招待講演)
    • Year and Date
      2012-07-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Abnormal brain development in maltreated children.2012

    • Author(s)
      Tomoda A.
    • Organizer
      Australasian Conference of Child Trauma (ACOCT) 2012 Congress
    • Place of Presentation
      Gold Coast, Australia(招待講演)
    • Year and Date
      2012-07-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Attention deficit/hyperactivity disorder (ADHD) in childhood and adolescence isassociated with decreased gray matter volume in the thalamus.2012

    • Author(s)
      Tomoda A, Mizuno K, Yoneda T, Yatsuga C, Takiguchi S, Yamazaki M.
    • Organizer
      12th ICNC & 11th AOCCN Conference
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2012-05-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Attention deficit/hyperactivity disorder (ADHD) in childhood and adolescence is associated with decreased gray matter volume in the thalamus.

    • Author(s)
      Fujisawa TX, Tomoda A, Mizuno K, Yatsuga C, Takiguchi S.
    • Organizer
      15th International Congress of ESCAP-European Society for Child and Adolescent Psychiatry (ポスター発表)
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Assessment of gait asymmetry in children with and without ADHD: Approach using quantitative analysis.

    • Author(s)
      Naruse H, Yatsuga C, Fujisawa TX, Kumazaki H, Mizushima S, Takiguchi S, Aoi T, Kojima M, Koizumi M, Shimada S, Tomoda A.
    • Organizer
      International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology (Fukui2014: The Fifth International Workshop on Biomedical Imaging)(ポスター発表)
    • Place of Presentation
      Fukui、Yours Hotel Fukui
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gait differences in children with and without ADHD, A quantitative analysis.

    • Author(s)
      Naruse H, Yatsuga C, Fujisawa TX, Takiguchi S, Mizushima S, Aoi T, Kojima M, Koizumi M, Shimada S, Baba H, Nakai A, Tomoda A.
    • Organizer
      2nd Asian Congress on ADHD(ポスター発表)
    • Place of Presentation
      Tokyo、東京医科大学病院
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of methylphenidate on neuropsychological performance in children with ADHD using the Cambridge Neuropsychological Test Automated Battery (CANTAB).

    • Author(s)
      Arai S, Inohara K, Fujioka T, Ishitobi M, Asano M, Kawamura K, Jung M, Wada Y, Tomoda A, Hiratani M, Matsuura N, Kosaka H.
    • Organizer
      2nd Asian Congress on ADHD(ポスター発表)
    • Place of Presentation
      Tokyo、東京医科大学病院
    • Related Report
      2013 Annual Research Report
  • [Presentation] Symposium: Mania and ADHD: Common symptoms, common pathophysiology, and common treatment?

    • Author(s)
      Tomoda A, Mizuno K. Brain activity involved in reward sensitivity in pediatric ADHD before and after MPH treatment.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都市、京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 「こころを脳画像で観る~薬剤導入による脳機能変化~」

    • Author(s)
      友田 明美
    • Organizer
      平成25年度 長崎大学大学院セミナー
    • Place of Presentation
      長崎市、長崎大学医歯薬学総合研究科
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「発達障害の診断と治療効果を画像で知る」

    • Author(s)
      友田 明美
    • Organizer
      第5回埼玉子どものこころ臨床研究会特別講演
    • Place of Presentation
      大宮市、大宮ソニックシティ
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「エビデンスに基づく注意欠陥多動性障害(ADHD)の治療戦略 ~薬剤導入による脳機能変化~」

    • Author(s)
      友田 明美
    • Organizer
      第17回活性アミンに関するワークショップ 特別講演
    • Place of Presentation
      福井市、AOSSA福井
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「ADHDの診断と治療効果を画像で知る」

    • Author(s)
      友田 明美
    • Organizer
      名古屋市立大学 医療・保健「学び直し講座:発達障害を学ぶ、医学的理解から教育/療育へ」
    • Place of Presentation
      名古屋市、名古屋市立大学病院
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「こころを脳画像で観る~薬剤導入による脳機能変化~」

    • Author(s)
      友田 明美
    • Organizer
      神戸大学大学院セミナー
    • Place of Presentation
      神戸市、神戸大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「こころを脳画像で観る~薬剤導入による脳機能変化~」

    • Author(s)
      友田 明美
    • Organizer
      第17回いばらき発達障害研究会特別講演
    • Place of Presentation
      つくば市、筑波大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「エビデンスに基づく注意欠陥多動性障害(ADHD)の治療戦略 ~薬剤導入による脳機能変化~」

    • Author(s)
      友田 明美
    • Organizer
      平成25年度 熊本大学薬学教育部大学院「先端医療学特論」セミナー
    • Place of Presentation
      熊本市、熊本大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Task-based fMRI in ADHD.

    • Author(s)
      Fujisawa T, Tomoda A.
    • Organizer
      Symposium: ADHD and brain, 2nd Asian Congress on ADHD
    • Place of Presentation
      東京都、東京医科大学病院
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 「エビデンスに基づく注意欠陥多動性障害(ADHD)の治療戦略 ~薬剤導入による脳機能変化~」

    • Author(s)
      友田 明美
    • Organizer
      日本薬理学会年会プレセミナー第23回神経行動薬理若手研究者の集い 特別講演
    • Place of Presentation
      仙台市、艮陵会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 日本生物学的精神医学会誌, 25巻4号 (躁病と注意欠陥多動性障害(ADHD):症状、病態、治療法は共通か?)2015

    • Author(s)
      友田明美、渡辺 義文、小田恒 雄二
    • Total Pages
      30
    • Publisher
      株式会社新興医学出版社
    • Related Report
      2014 Annual Research Report
  • [Book] こころの科学「神経発達障害のすべて」(森 則夫, 杉山登志郎編)(注意欠如/多動性障害(ADHD)の病態).2014

    • Author(s)
      森 則夫, 杉山登志郎,友田 明美
    • Total Pages
      114
    • Publisher
      日本評論社
    • Related Report
      2014 Annual Research Report
  • [Book] こころの科学「神経発達障害のすべて」(森 則夫, 杉山登志郎編)(ADHDの治療戦略.)2014

    • Author(s)
      森 則夫, 杉山登志郎,友田 明美,熊崎博一
    • Total Pages
      114
    • Publisher
      日本評論社
    • Related Report
      2014 Annual Research Report
  • [Book] 臨床精神薬理, 17巻9号(AD/HDと物質関連障害.)2014

    • Author(s)
      熊崎博一、 友田明美、岡田 俊
    • Total Pages
      120
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 小児科学レクチャー『子どもの発達と心の問題Q&A-健診から思春期までの評価と指導の実際-』2012

    • Author(s)
      滝口慎一郎,友田明美
    • Publisher
      総合医学社
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://tomoda.me/Home.html

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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