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Development of autologous scaffolds

Research Project

Project/Area Number 24300177
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Institute for Materials Science

Principal Investigator

CHEN Guoping  独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, ユニット長 (50357505)

Co-Investigator(Renkei-kenkyūsha) KAWAZOE Naoki  物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (90314848)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsマトリックス / 足場材料 / 三次元細胞培養 / 鋳型法 / 脱細胞化 / 多孔質構造 / 生体親和性
Outline of Final Research Achievements

A method to prepare cultured cells derived extracellular matrix scaffolds was developed by using three-dimensional cell culture and template method. Various cell types can be used for preparation of their respective extracellular matrix scaffolds. Autologous extracellular matrix scaffolds prepared from autologous cells showed excellent biocompatibility without eliciting adverse inflammatory and immune responses when being implanted. The scaffolds will be useful for control the functions of stem cells and for regenerative medicine.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results) Presentation (21 results) (of which Invited: 10 results) Book (4 results)

  • [Journal Article] Influence of surfaces modified with biomimetic extracellular matrices on adhesion and proliferation of mesenchymal stem cells and osteosarcoma cells2015

    • Author(s)
      Rong Cai, Naoki Kawazoe and Guoping Chen
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 126 Pages: 381-386

    • DOI

      10.1016/j.colsurfb.2014.11.050

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Influence of stepwise chondrogenesis-mimicking 3D extracellular matrix on chondrogenic differentiation of mesenchymal stem cells2015

    • Author(s)
      Rong Cai, Tomoko Nakamoto, Naoki Kawazoe and Guoping Chen
    • Journal Title

      Biomaterials

      Volume: 52 Pages: 199-207

    • DOI

      10.1016/j.biomaterials.2015.02.033

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stem cell culture using cell-derived substrates2014

    • Author(s)
      Binata Joddar, Takashi Hoshiba, Guoping Chen, and Yoshihiro Ito
    • Journal Title

      Biomaterials Science

      Volume: 2 Issue: 11 Pages: 1595-1603

    • DOI

      10.1039/c4bm00126e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of extracellular matrix proteins in chondrocyte-derived matrices on chondrocyte functions2013

    • Author(s)
      Takashi Hoshiba, Tomoe Yamada, Hongxu Lu, Naoki Kawazoe, Guoping Chen
    • Journal Title

      Biotechnology Progress

      Volume: 29 Issue: 5 Pages: 1331-1336

    • DOI

      10.1002/btpr.1780

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Collagen Scaffolds with Controlled Pore Structures and Improved Mechanical Property for Cartilage Tissue Engineering2013

    • Author(s)
      Qin Zhang, Hongxu Lu, Naoki Kawazoe, Guoping Chen
    • Journal Title

      Journal of Bioactive and Compatible Polymers

      Volume: 28(in press) Issue: 5 Pages: 426-438

    • DOI

      10.1177/0883911513494620

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Decellularization Techniques for Preparation of Extracellular Matrix2012

    • Author(s)
      Hongxu Lu, Takashi Hoshiba, Naoki Kawazoe, Guoping Chen
    • Journal Title

      Journal of Biomedical Materials Research : PartA

      Volume: 100 Issue: 9 Pages: 2507-2516

    • DOI

      10.1002/jbm.a.34150

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Design and Preparation of Porous Scaffolds and Biomimetic Matrices for Tissue Engineering2014

    • Author(s)
      Guoping Chen
    • Organizer
      1st Asian University Symposium on Biomedical Engineering
    • Place of Presentation
      台湾
    • Year and Date
      2014-12-12 – 2014-12-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of Biomimetic 3D ECM Scaffolds for Tissue Regeneration2014

    • Author(s)
      Chen G, Cai R, Nakamoto T, Kawazoe N
    • Organizer
      7th World Congress on Preventive and Regenerative Medicine
    • Place of Presentation
      台湾
    • Year and Date
      2014-11-04 – 2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Effects of Stepwise Tissue Development-Mimicking Matrices on MSCs Differentiation2014

    • Author(s)
      Guoping Chen, Rong Cai, Takashi Hoshiba and Naoki Kawazoe
    • Organizer
      2014 International Symposium of Materials on Regenerative Medicine
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Preparation of Functional Polymer Scaffolds for Tissue Engineering2014

    • Author(s)
      Guoping Chen, Qin Zhang, Hongxu Lu and Naoki Kawazoe
    • Organizer
      NIMS Conference 2014
    • Place of Presentation
      つくば
    • Year and Date
      2014-07-01 – 2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hybrid Polymer and Biomimetic Matrix Scaffolds for Tissue Engineering2014

    • Author(s)
      Guoping Chen
    • Organizer
      2014 International Symposium on Nano-biomaterials and Nanomedicine
    • Place of Presentation
      香港
    • Year and Date
      2014-04-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨及び脂肪組織発生模倣型マトリックスの作製2014

    • Author(s)
      陳国平, 干場隆志, 川添直輝
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biomimetic matrices and hybrid scaffolds for tissue engineering2013

    • Author(s)
      Guoping Chen, Hongxu Lu, Takashi Hoshiba, Hwan Hee Oh, Naoki Kawazoe
    • Organizer
      22nd Annual Meeting of Australasian Society for Biomaterials and Tissue Engineering
    • Place of Presentation
      Barossa Valley, Australia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Biomimetic Matrices and Porous Scaffolds for Tissue Engineering2013

    • Author(s)
      Guoping Chen
    • Organizer
      2013 International Conference on Applied Biomaterials
    • Place of Presentation
      Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Extracellular Matrix-Based Biomaterials for Tissue Engineering2013

    • Author(s)
      Guoping Chen, Hongxu Lu, Takashi Hoshiba, Naoki Kawazoe
    • Organizer
      7th International Conference on the Science and Technology for Advanced Ceramics
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cultured cell-derived extracellular matrix scaffolds for2013

    • Author(s)
      Guoping Chen, Hongxu Lu, Takashi Hoshiba, Naoki Kawazoe
    • Organizer
      4th Asian Biomaterials Congress
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生体組織発生模倣型マトリックスの創出及び幹細胞分化制御への応用2013

    • Author(s)
      陳国平, CAIRong, 干場隆志, 川添直輝
    • Organizer
      第62回高分子討論会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] Design and Fabrication of Biodegradable Polymer Porous Scaffolds and Biomimetic Matrices for Tissue Engineering2013

    • Author(s)
      Guoping Chen
    • Organizer
      2013 Symposium on Biomaterials for Regenerative Medicine
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Biomimetic ECM and Polymeric Porous Scaffolds for Tissue Engineering2013

    • Author(s)
      Guoping Chen
    • Organizer
      中国生物材料学会2013年大会
    • Place of Presentation
      Shenzhen, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 培養細胞由来のマトリックス足場材料の作製2012

    • Author(s)
      陳国平、呂宏旭、川添直輝
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2012-11-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] ECM Scaffolds Prepared from Cultured Cells2012

    • Author(s)
      Guoping Chen, Hongxu Lu, and Naoki Kawazoe
    • Organizer
      12^<th> Asia BioCeramics Symposium
    • Place of Presentation
      成功大学(台湾)(招待講演)
    • Year and Date
      2012-11-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Biomimetic Matrices and Scaffolds Derived from Cultured Cells2012

    • Author(s)
      Guoping Chen, Hongxu Lu, Takashi Hoshiba, Naoki Kawazoe
    • Organizer
      IUMRS-International Conference on Electronic Materials(IUMRS.ICEM 2012)
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2012-09-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Autologous Extracellular Matrix Scaffolds Prepared from Cultured Cells2012

    • Author(s)
      Guoping Chen, Hongxu Lu, and Naoki Kawazoe
    • Organizer
      3^<rd> TERMIS World Congress
    • Place of Presentation
      Hofburg Congress Centre (Vienna, Austria)
    • Year and Date
      2012-09-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cultured Cell-Derived Matrices for Tissue Engineering and Stem Cell Function2012

    • Author(s)
      Guoping Chen, Hongxu Lu, Takashi Hoshiba, Naoki Kawazoe
    • Organizer
      2012 International Symposium of Materials on Regenerative Medicine (2012 ISOMRM)
    • Place of Presentation
      Taipei Medical University (Taipei, Taiwan)
    • Year and Date
      2012-08-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of Biomimetic Autologous Extracellular Matrix scaffolds2012

    • Author(s)
      Hongxu Lu, Takashi Hoshiba, Naoki Kawazoe, Guoping Chen
    • Organizer
      9^<th> World Biomaterials Congress
    • Place of Presentation
      New Century International Exhibition and Convention Center (Chengdu, China)
    • Year and Date
      2012-06-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Biomimetic Extracellular Matrix Biomaterials for Stem Cell Function Manipulation and Tissue Regeneration2012

    • Author(s)
      Guoping Chen, Hongxu Lu, Takashi Hoshiba, Naoki Kawazoe
    • Organizer
      International Forum of Biomedical Materials : Nanobiomaterials for Tissue Regeneration
    • Place of Presentation
      Zhejiang University (Hangzhou, China)(招待講演)
    • Year and Date
      2012-05-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞由来のECM足場材料の軟骨組織再生への応用2012

    • Author(s)
      陳国平、呂宏旭、川添直輝
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2012-03-22
    • Related Report
      2012 Annual Research Report
  • [Book] 動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術2014

    • Author(s)
      陳国平, 川添直輝
    • Total Pages
      5
    • Publisher
      技術情報協会
    • Related Report
      2014 Annual Research Report
  • [Book] Biomimetics: Advancing Nanobiomaterials and Tissue Engineering2013

    • Author(s)
      Guoping Chen, Hongxu Lu, Naoki Kawazoe
    • Total Pages
      9
    • Publisher
      Scrivener Publishing, Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] World Scientific2013

    • Author(s)
      Guoping Chen, Takashi Hoshiba, Naoki Kawazoe
    • Total Pages
      13
    • Publisher
      Tissue Regeneration: Where Nano-Structures Meets Biology
    • Related Report
      2013 Annual Research Report
  • [Book] 体内埋め込み医療材料の開発とその理想的な性能・デザインの要件2013

    • Author(s)
      陳国平、川添直輝
    • Total Pages
      4
    • Publisher
      技術情報協会
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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