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Physical therapy to promote the recovery from muscle injury in rat

Research Project

Project/Area Number 24300191
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNagoya University

Principal Investigator

KAWAAKAMI Keisuke  名古屋大学, 医学(系)研究科(研究院), 准教授 (60195047)

Co-Investigator(Kenkyū-buntansha) SOKABE Masahiro  名古屋大学, 医学系研究科, 教授 (10093428)
曽我 浩之  近大姫路大学, 看護学部, 教授 (20282121)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords骨格筋 / 筋損傷 / 機械刺激 / 超音波 / ラット / リハビリテーション
Outline of Final Research Achievements

To evaluate the effect of ultrasound and stretching on recovery from muscle injury, changes in muscle force production and myogenic gene expressions were investigated in an LC-induced muscle injury mode of rat. We established the LC-induced muscle injury model, whose injury was histologically confirmed to be equivalent. The results show that ultrasonic stimulation and stretching added once after muscle injury on the TA effectively promotes recovery from muscle injury according to histological and physiological evaluation. Additionally, during recovery from muscle injury the activation of muscle satellite cells early after muscle injury is suggested to be involved.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (15 results)

All 2014 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Invited: 4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Stretch speed-dependent myofibre damage and functional deficits in rat skeletal muscle induced by lengthening contraction2014

    • Author(s)
      Mori T., Agata N., Itoh Y., Inoue-Miyazu M., Sokabe M., Taguchi T., Kawakami K.
    • Journal Title

      Physiological Reports

      Volume: 2 Issue: 11 Pages: 1-10

    • DOI

      10.14814/phy2.12213

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 基礎理学療法学-理学療法と科学のインテグレーション-2014

    • Author(s)
      河上敬介
    • Organizer
      第1回日本基礎理学療法学会学術集会・日本基礎理学療法学会第4回学術大会 合同学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Short time of unloading promotes protein synthesis before increasing atrogin-1 expression in unloading-induced muscle atrophy model in culture.2014

    • Author(s)
      Yoshioka K., Kurogi Y., Sasai N., Hayakawa K., Murakami T., Kawakami K.
    • Organizer
      The International Symposium on Mechanobiology 2014
    • Place of Presentation
      Okayama
    • Year and Date
      2014-05-21 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 伸張刺激による筋損傷からの機能的回復促進効果2012

    • Author(s)
      森友洋
    • Organizer
      第11回コ・メディカル形態機能学会学術集会
    • Place of Presentation
      首都大学東京荒川キャンパス(東京都)
    • Year and Date
      2012-09-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 再現遠心性収縮による筋損傷モデルの組織学的・機能的回復2012

    • Author(s)
      森友洋
    • Organizer
      第47回日本理学療法学術大会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2012-05-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 伸張刺激による筋損傷からの機能的及び組織学的回復促進効果

    • Author(s)
      森友洋
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超音波刺激が筋損傷の回復過程に与える影響

    • Author(s)
      柴田篤志
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ultrasonic stimulation to promote recoverry from muscle injury.

    • Author(s)
      Shibata A.
    • Organizer
      The 6th WCPT-AWP & 12th ACPT Congress 2013
    • Place of Presentation
      Nan Shan Education & Training Center(Taichung,Taiwan.)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The recovery facilitatory effect for muscle injury by stretch stimulation.

    • Author(s)
      Mori T.
    • Organizer
      The 6th WCPT-AWP & 12th ACPT Congress 2013
    • Place of Presentation
      Nan Shan Education & Training Center(Taichung,Taiwan.)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 筋損傷の予防、治療、復帰

    • Author(s)
      河上敬介
    • Organizer
      一般社団法人日本整形外科スポーツ医学会第39回学術集会
    • Place of Presentation
      ウィンクあいち(名古屋市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 理学療法の基礎研究の現状と近未来への提言

    • Author(s)
      河上敬介
    • Organizer
      第32回関東甲信越ブロック理学療法士学会
    • Place of Presentation
      幕張メッセ 国際会議場(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 骨格筋に対する効果的な伸張刺激の与え方

    • Author(s)
      河上敬介
    • Organizer
      公益社団法人鹿児島県理学療法士協会第27回学会
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 筋機能改善の理学療法とそのメカニズム(第3版)分担部分:第11章 機械刺激に対する骨格筋の応答2014

    • Author(s)
      河上敬介,宮津真寿美
    • Total Pages
      21
    • Publisher
      ナップ
    • Related Report
      2014 Annual Research Report
  • [Remarks] 河上&宮津研究室

    • URL

      http://www.kmnu.matrix.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.kmnu.matrix.ip/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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