Does physical exercise have a capacity for inducing the differentiation from white adipocytes to brown adipocytes ?: its application to prevent or cure obesity

• Project/Area Number: 24300223
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: OHNO Hideki 杏林大学, 医学部, 名誉教授 (00133819)
• Co-Investigator(Renkei-kenkyūsha): KIZAKI Takako 杏林大学, 医学部, 教授 (00322446) ; SAKURAI Takuya 杏林大学, 医学部, 講師 (20353477) ; OGASAWARA Junetsu 杏林大学, 医学部, 助教 (20415110)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: 褐色脂肪細胞 / 運動 / 分化 / 白色脂肪細胞 / トレーニング / ブライト脂肪細胞 / 運動トレーニング / 細胞分化 / 肥満治療 / UCP-1 / Zic-1遺伝子 / 誘導型褐色脂肪細胞

Outline of Final Research Achievements

The purpose of the current study was to investigate the effect of habitual physical exercise training (ET) on browning, which results in producing brite adipocytes, of mature white adipocytes in several white adipose tissues from rats. In both inguinal and retroperitoneal adipose tissue, ET, which was loaded for 10 weeks, has shown to provoke the browning of white adipocytes. Under these conditions, levels of marker molecules of brite adipocytes and transcription modulating factors such as PRDM16 and/or PPAR were significantly elevated compared with sedentary control. It has been shown that browning of inguinal adipocytes might be related with the alteration in levels of activin receptor mRNA, although browning of retroperitoneal adipocytes might depend on changes in BMP7 mRNA. It was suggested, thus, that ET might have an ability to induce the browning of white adipose cells on these tissues through its region-specific modification events.

Research Products

• [Journal Article] Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBα. (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Oh-ishi S, Imaizumi K, Haga S, Hitomi Y, Izawa T, Ohira Y, Ohno H & Kizaki T
  • Journal Title: The Scientific World Journal Volume: 2014 Pages: 685854-685854
  • DOI: 10.1155/2014/685854
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of smoking with intraocular pressure in middle-aged and older Japanese residents (2014)
  • Author(s): Yoshida M, Take S, Ishikawa M, Kokaze A, Karita K, Harada M & Ohno H
  • Journal Title: Environ Health Prev Med Volume: 19 Issue: 2 Pages: 100-107
  • DOI: 10.1007/s12199-013-0359-1
  • NAID: 210000000298
  • ISSN: 1342-078X, 1347-4715
  • Peer Reviewed
• [Journal Article] A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. (2014)
  • Author(s): Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
  • Journal Title: The Journal of Immunology Volume: 192 Pages: 407-417
  • DOI: 10.4049/jimmunol.1301982
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enzyme-treated asparagus offcinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice. (2014)
  • Author(s): Sakurai, T., et al.
  • Journal Title: Nat Prod Commun Volume: 9 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Association of blood pressure and body mass index with intraocular pressure in middle-aged and older Japanese Residents : A cross-sectional and longitudinal study. (2014)
  • Author(s): Yoshida, M., et al.
  • Journal Title: Acta Med Okayama Volume: 68 Pages: 27-34
  • Peer Reviewed
• [Journal Article] The effects of long-term exercise on cerebral function and the maintenance of concentration in the elderly. (2014)
  • Author(s): Haga, S., et al.
  • Journal Title: J Exer Sports Orthop Volume: 1 Pages: 6-11
  • Peer Reviewed
• [Journal Article] ETAS, an enzyme-treated asparagus extract, attenuates amyloid β-induced cellular disorder in PC12 cells. (2014)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Nat Prod Commun Volume: 9 Pages: 561-564
  • Peer Reviewed
• [Journal Article] Intracellular β2-adrenergic receptor signaling specificity in mouse skeletal muscle in response to single-dose β2-agonist clenbuterol treatment and acute exercise (2013)
  • Author(s): Sato, S., Shirato, K., Mitsuhashi, R., Inoue, D., Kizaki, T., Ohno, H., Tachiyashiki, K. & Imaizumi, K
  • Journal Title: Journal of Physiological Sciences Volume: 63 Pages: 211-218
  • DOI: 10.1007/s12576-013-0253-z
  • Peer Reviewed
• [Journal Article] Oxygen consumption and usage during physical exercise: The balance between oxidative stress and ROS-dependent adaptive signaling (2013)
  • Author(s): Radak, Z., Zhao, Z., Koltai, E., Ohno, H. & Atalay, M
  • Journal Title: Antioxid Redox Signal Volume: 18 Pages: 1208-1246
  • DOI: 10.1089/ars.2011.4498
  • Peer Reviewed
• [Journal Article] Redox- regulating sirtuins in aging, caloric restriction, and exercise (2013)
  • Author(s): Radak, Z., Koltai, E., Taylora, AW., Higuchi, M., Kumagai, S., Ohno, H., Goto, S. & Boldogh, I
  • Journal Title: Free Radic Biol Med Volume: 58 Pages: 87-97
  • DOI: 10.1016/j.freeradbiomed.2013.01.004
  • Peer Reviewed
• [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells. (2013)
  • Author(s): Sakurai T, Kitadate K, Nishioka H, Fujii H, Ogasawara J, Kizaki T, Sato S, Fujiwara T, Akagawa K, Izawa T, Ohno H.
  • Journal Title: Br J Nutr Volume: 110 Pages: 1549-1558
  • DOI: 10.1017/s000711451300086x
  • Peer Reviewed
• [Journal Article] Endogenous oxidative stress, but not ER stress, induces hypoxia-independent VEGF120 release through PI3K-dependent pathways in 3T3-L1 adipocytes. (2013)
  • Author(s): Takahashi, K., et al.
  • Journal Title: Obesity Volume: 21 Pages: 1615-1624
  • DOI: 10.1002/oby.20206
  • Peer Reviewed
• [Journal Article] Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle (2013)
  • Author(s): Tomonobu Sakurai, Osamu Kashimura, Yutaka Kano, Hideki Ohno, Li Li Ji, Tetsuya Izawa, Thomas M. Best
  • Journal Title: J. Physiol. Sci. Volume: 63(4) Pages: 252-256
  • DOI: 10.1007/s12576-013-0262-y
  • NAID: 10031184279
  • Peer Reviewed
• [Journal Article] Skeletal muscle oxygenation during the nagewaza kakari exercise in judo. (2013)
  • Author(s): Haga, S., et al.
  • Journal Title: Sport Sci Res Volume: 10 Pages: 233-241
  • Peer Reviewed
• [Journal Article] The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue. (2013)
  • Author(s): Sakurai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Takahashi M, Kobayashi O, Oh-Ishi S, Nagasawa J, Takahashi K, Ishida H, Izawa T, Ohno H.
  • Journal Title: Int J Endocrinol Volume: Article ID801743 Pages: 1-28
  • DOI: 10.1155/2013/801743
  • Peer Reviewed
• [Journal Article] Exercise and oxidant stress in hypoxia. (2013)
  • Author(s): Nagasawa, J., et al.
  • Journal Title: J Phys Fit Sports Med Volume: 2 Pages: 481-486
  • Peer Reviewed
• [Journal Article] Interrelationship among blood pressure, intraocular pressure, and life-style in middle-aged and older Japanese resident (2013)
  • Author(s): Yoshida M, Take S, Ishikawa M, Karita K, Kokaze A, Harada M & Ohno H
  • Journal Title: Health Volume: 5 Pages: 1527-1532
  • DOI: 10.4236/health.2013.510207
  • Peer Reviewed
• [Journal Article] Effects of resistance exercise on intramuscular oxygenation and muscle fiber composition. (2013)
  • Author(s): Aita, F., et al.
  • Journal Title: J Sports MedDoping Stud Volume: 3 Pages: 3-9
  • DOI: 10.4172/2161-0673.1000133
  • Peer Reviewed
• [Journal Article] 高所環境は肥満を改善する. (2013)
  • Author(s): 大野秀樹ほか
  • Journal Title: 登山医学 Volume: 33 Pages: 167-171
  • Peer Reviewed
• [Journal Article] Oligomerised lychee flult-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells. (2013)
  • Author(s): Sakurai, T., et al.
  • Journal Title: Br. J. Nutr. Volume: 109(in press)
  • Peer Reviewed
• [Journal Article] Endogenous oxidative stress induces hypoxla-independent VEGF120 release via PI3K-dependent pathways in 3T3-L1 adipocytes. (2013)
  • Author(s): Takahashi, K., et al.
  • Journal Title: Obesity Volume: 21(in press)
  • Peer Reviewed
• [Journal Article] Oligonol-induced degradation of perilipin 1 is regulated through lysosomal degradation machinery. (2012)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Nat. Prod. Commun. Volume: 7 Pages: 1193-1196
  • Peer Reviewed
• [Journal Article] Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes. (2012)
  • Author(s): 小笠原準悦
  • Journal Title: PLoS One Volume: 7(7)
  • DOI: 10.1371/journal.pone.0040876
  • Peer Reviewed
• [Journal Article] Recent advances in the adaptations of adipose tissue to physical activity : Morphology and adipose tissue cellularity. (2012)
  • Author(s): Izawa, T., et al.
  • Journal Title: J. Phys. Fit. Sports Med. Volume: 1 Pages: 381-387
  • Peer Reviewed
• [Journal Article] 登山に対する電気伝導率を利用した疲労評価 (2012)
  • Author(s): 内藤祐二郎
  • Journal Title: 登山医学 Volume: 32 Pages: 148-154
  • Peer Reviewed
• [Presentation] 脂肪細胞の糖取り込みを抑制するTGF-β-TIMP1経路は運動によって減弱される. (2015)
  • Author(s): 櫻井拓也、小笠原準悦、白土健、石橋義永、井澤鉄也、大石修司、芳賀脩光、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館、ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] ブライト脂肪細胞の形成を修飾する持久的走運動トレーニングの効果. (2015)
  • Author(s): 小笠原準悦、櫻井拓也、白土健、石橋義永、井澤鉄也、大石修司、芳賀脩光、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館、ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 高グルコースによるマクロファージ炎症反応の亢進における時計遺伝子Rev-erbaの役割. (2015)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、石橋義永、佐藤章悟、今泉和彦、大野秀樹、木崎節子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館、ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 高グルコース培養によるマクロファージの時計遺伝子Rev-erbαの発現変化とその生理的役割. (2014)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、木本紀代子、高橋和人、住谷由計、石田均、大野秀樹、木﨑節子
  • Organizer: 第43回杏林医学会総会
  • Place of Presentation: 杏林大学（東京都三鷹市）
  • Year and Date: 2014-11-15
• [Presentation] マクロファージ時計遺伝子Rev-erbaの発現に及ぼす高血糖の影響. (2014)
  • Author(s): 白土健、櫻井拓也、小笠原準悦、佐藤章悟、今泉和彦、大野秀樹、木﨑節子
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、グランドプリンスホテル京都（京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 運動によって減少するTGF-β-TIMP1経路は脂肪細胞の糖取り込みに関与する. (2014)
  • Author(s): 櫻井拓也、小笠原準悦、白土健、石橋義永、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 走運動トレーニングはブライト脂肪細胞の形成を促進するか. (2014)
  • Author(s): 小笠原準悦、櫻井拓也、白土健、長澤純一、井澤鉄也、大野秀樹、木崎節子
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 脂肪細胞の分化及び脂肪滴形成に及ぼすメラトニンの影響. (2014)
  • Author(s): 田中剛貴、加藤久詞、柴原拓哉、高倉久志、増田慎也、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 時計遺伝子の発現リズムに合わせたイソプロテレノール刺激が脂肪分解反応に及ぼす影響. (2014)
  • Author(s): 加藤久詞、柴原拓哉、田中剛貴、増田慎也、高倉久志、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 運動トレーニングが脂肪組織のホメオテイック遺伝子と骨形成タンンパク質に及ぼす影響. (2014)
  • Author(s): 柴原拓哉、加藤久詞、田中剛貴、増田慎也、高倉久志、稗田睦子、白土健、小笠原準悦、櫻井拓也、木﨑節子、大野秀樹、井澤鉄也
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎大学文教キャンパス（長崎市）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] ETAS, an enzyme-treated asparagus extract, has the ability to enhance both the differentaion and the neurite outgrowth in PC12 cells. (2014)
  • Author(s): Ogsawara J, Takanari J, Sakurai T, Shirato K, Ishibashi Y, Nagasawa J, Izawa T, Ohno H & Kizaki T
  • Organizer: The 22nd International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Hotel Royton Sapporo（Sapporo, Hokkaido）
  • Year and Date: 2014-07-26 – 2014-07-27
• [Presentation] マクロファージ炎症性応答に及ぼすグルコサミンの効果とメカニズム. (2014)
  • Author(s): 白土健、木﨑節子、櫻井拓也、小笠原準悦、大野秀樹、今泉和彦
  • Organizer: 第161回日本体力医学会関東地方会
  • Place of Presentation: 女子栄養大学（埼玉県坂戸市）
  • Year and Date: 2014-07-26
• [Presentation] リポ多糖刺激に伴うマクロファージ炎症性応答に及ぼすグルコサミンの抑制作用とメカニズム. (2014)
  • Author(s): 白土健、木﨑節子、大野秀樹、今泉和彦
  • Organizer: 第68回日本栄養・食糧学会大会
  • Place of Presentation: 札幌市教育文化会館、酪農学園大学（北海道札幌市）
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 運動は肥満による脂肪組織の線維化関連因子の発現増加を減弱させる. (2014)
  • Author(s): 櫻井拓也、小笠原準悦、木崎節子、白土健、石橋義永、斎藤大蔵、大石修司、芳賀脩光、鈴木健二、大野秀樹
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター、岡山国際交流センター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] アスパラガス茎熱水抽出物（ETAS）はアミロイドβによる細胞障害性を抑制する. (2014)
  • Author(s): 小笠原準悦、伊藤知洋、高成準、三浦健人、櫻井拓也、井澤鉄也、中野法彦、長澤純一、木崎節子、大野秀樹
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター、岡山国際交流センター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] 酵素処理アスパラガス抽出物は神経細胞において抗ストレス作用をもつ. (2013)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学鶴間キャンパス(金沢)
  • Year and Date: 2013-03-25
• [Presentation] 富士登山時の酸化ストレスに対する年齢差の影響 (2013)
  • Author(s): 高橋達彦, ほか
  • Organizer: 特定非営利活動法人富士山測候所を活用する会、第6回成果報告会
  • Place of Presentation: 東京大学小柴ホール(東京)
  • Year and Date: 2013-01-27
• [Presentation] 酵素処理アスパラガス抽出物ETASTMによる抗ストレス作用. (2012)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第16回日本統合医療学会
  • Place of Presentation: 大阪大学コンベンションセンター(吹田)(招待講演)
  • Year and Date: 2012-12-09
• [Presentation] 酵素処理アスパラガス抽出物は神経細胞障害を減弱させ、老化促進モデルマウスの認知機能障害を予防する. (2012)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第41回杏林医学会総会
  • Place of Presentation: 杏林大学(三鷹)
  • Year and Date: 2012-11-17
• [Presentation] The enzyme-treated Asparagus offcinalis extract shows anti-stress effects in neural cells and prevents cognitive impairment in senescense-accelerated mice. (2012)
  • Author(s): Sakurai, T., et al.
  • Organizer: The 6^<th> Inteternational Niigata Symposium on Diet and Health
  • Place of Presentation: TOKI MESSE (Niigata)
  • Year and Date: 2012-10-17
• [Presentation] 運動は肥満による脂肪組織のデルマトポンチン発現増加を減弱させる. (2012)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2012-09-15
• [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化を促進する (2012)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第20回日本運動生理学会大会
  • Place of Presentation: 筑波大学大学会館(つくば)
  • Year and Date: 2012-07-29
• [Presentation] The extract from stems of Asparagus officinalis enhances the expression of heat shock proteins and shows anti-stress effects in neural cells. (2012)
  • Author(s): Sakurai, T., et al.
  • Organizer: The 20th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: ホテルロイトン札幌(札幌)
  • Year and Date: 2012-07-22
• [Presentation] 運動を用いた痩身への誘い～運動によって白色脂肪細胞では何が起こるの～ (2012)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 平成24年度生理学若手研究フォーラム
  • Place of Presentation: 順天堂大学(東京)
  • Year and Date: 2012-06-30
• [Presentation] 有害金属汚染患者における尿中誘発試験の有用性 (2012)
  • Author(s): 増尾正, ほか
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2012-06-24
• [Presentation] 運動するとなぜ痩せる?～白色脂肪細胞ではいったい何がおこるのか～ (2012)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第14回日本体力医学会北海道地方会
  • Place of Presentation: 北方圏学術情報センターPORTO(札幌)(招待講演)
  • Year and Date: 2012-06-17
• [Presentation] 登山に対する電気伝導率を利用した疲労評価 (2012)
  • Author(s): 内藤祐二郎, ほか
  • Organizer: 第32回日本登山医学会学術集会
  • Place of Presentation: エルガーラホール(福岡)
  • Year and Date: 2012-06-16
• [Presentation] 持久性走トレーニングによる白色脂肪細胞の脂肪分解反応の亢進にはATGLの発現変化が関与する.
  • Author(s): 小笠原準悦ほか
  • Organizer: 第158回日本体力医学会関東地方会
  • Place of Presentation: 新座
• [Presentation] 運動は肥満による脂肪組織の線維化関連因子の発現増加を減弱させる.
  • Author(s): 櫻井拓也ほか
  • Organizer: 第21回日本運動生理学会大会
  • Place of Presentation: 川越
• [Presentation] Inhibitory effect of ETAS against amyloid beta-induced cellular disorder in PC12 cells.
  • Author(s): Ogasawara, J., et al.
  • Organizer: 21st International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
• [Presentation] Effect of frequent antioxidant supplementation on oxidative stress when climbing Mt. Fuji.
  • Author(s): Nagasawa, J., et al.
  • Organizer: 21st International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
• [Presentation] 脂肪組織および骨格筋組織における時計遺伝子と脂質代謝関連遺伝子の関連性.
  • Author(s): 加藤久詞ほか
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 水泳運動は前駆細胞からの褐色脂肪細胞化を促す.
  • Author(s): 小笠原準悦ほか
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 時計遺伝子Rev-erbαはMCP1遺伝子発現を抑制しマクロファージ免疫機能を制御する.
  • Author(s): 佐藤章悟ほか
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 登山時の低酸素ストレス応答.
  • Author(s): 長澤純一ほか
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 運動は骨格筋前駆細胞から褐色脂肪細胞への分化を誘導するか：肥満予防・治療への応用.
  • Author(s): 小笠原準悦ほか
  • Organizer: 第42回杏林医学会総会
  • Place of Presentation: 三鷹
• [Presentation] A circadian clock gene Rev-erbα modulates inflammatory functions of macrophages through negative regulation of monocyte chemoattractant protein-1 expression.
  • Author(s): Kizaki, T., et al.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 運動と脂肪細胞の働き.
  • Author(s): 小笠原準悦ほか
  • Organizer: 第160回日本体力医学会関東地方会
  • Place of Presentation: 調布
• [Presentation] 水泳運動により誘導される肩甲骨周囲骨格筋群の褐色脂肪細胞化の検討.
  • Author(s): 小笠原準悦, ほか
• [Book] Proceeding 22th International Congress on Nutrition and Integrative Medicine (2014)
  • Author(s): Ogsawara J, Takanari J, Sakurai T, Shirato K, Ishibashi Y, Nagasawa J, Izawa T, Ohno H & Kizaki T
  • Total Pages: 241
  • Publisher: AHCC Research Association
• [Book] 活性酸素の本当の姿 (2014)
  • Author(s): 大野秀樹、木崎節子
  • Total Pages: 175
  • Publisher: ナップ
• [Book] ここまでわかった燃える褐色脂肪組織の不思議 (2013)
  • Author(s): 斎藤昌之、大野秀樹編
  • Total Pages: 158
  • Publisher: ナップ
• [Book] Proceeding 20th International Congress on Nutrition and Integrative Medicine (2013)
  • Author(s): Ogasawara, J., et al.
  • Total Pages: 102
  • Publisher: AHCC Research Association
• [Book] Proceeding 20th International Congress on Nutrition and Integrative Medicine (2013)
  • Author(s): Nagasawa, J., et al.
  • Total Pages: 102
  • Publisher: AHCC Research Association
• [Book] Proceedings 20th International Congress on Nutrition and Integrative Medicine (2012)
  • Author(s): Sakurai, T., et al.
  • Total Pages: 132
  • Publisher: AHCC Research Asociation