Cancer prevention, suppression of exercise-fatigue, and application for diabetic patients of heirloom vegetables in Kyoto
| Project/Area Number |
24300253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
NAKAMURA YASUSHI 京都府立大学, 生命環境科学研究科(系), 教授 (90285247)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Shigehisa 鹿児島大学, 農学部, 准教授 (30211808)
IMAI Toshio 独立行政法人国立がん研究センター, 動物実験支援施設, 支援施設長 (20342884)
AOI Wataru 京都府立大学, 生命環境科学研究科, 助教 (60405272)
TOKUDA Harukuni 金沢大学, 医学研究科, 客員准教授 (60111960)
KOBAYASHI Yukiko 京都府立大学, 生命環境科学研究科, 助教 (10381930)
KUBO Yasuyuki 京都府立大学, 生命環境科学研究科, 教授 (80183797)
MATSUO Tomoaki 鹿児島大学, 農学部, 名誉教授 (90041673)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 京野菜 / 伝統野菜 / 桂ウリ / がん / 運動 / 疲労 / 糖尿病 / 炭疽病菌 / 食品機能性 / 癌 / ウリ / 炭疽病 / 野菜 |
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| Outline of Final Research Achievements |
1. Methylthio acetic acid (MTA), a fragrant ingredient of Katsura-uri (Japanese pickling melon; Cucumis melo var. conomon) induced differentiation in human colon cancer cells with silencing effect of cyclinE2 gene, but did not alter a frequency of methylation of its transcriptional regulatory sequence. 2. Oral administration of MTA suppressed skin cancer (DMBA-TPA-induced) in ICR mice and mammary cancer (DMBA-induced) in Zucker rats． 3. Oral administration of MTA suppressed exercise-induced muscular fatigue with prevention of muscle acidification in ICR mice. 4. Novel application of Katsura-uri was developed for free from raising a blood glucose level in healthy human and diabetic patients. 5. Colletotrichum species were identified to be responsible bacteria that can occur black spots on the surface of fully ripened Katsura-uri fruit.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] The effect of Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon) and its derived ingredient 3-methylthioacetic acid on energy metabolism during prolonged exercise2015
Author(s)
Aoi W, Takeda K, Sasaki A, Hasegawa Y, Nakamura Y, Park EY, Sato K, Iwasa M, Nakayama A, Minamikawa M, Kobayashi Y, Shirota K, Suetome N
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Antimutagenic, differentiation-inducing, and antioxidative effects of fragrant ingredients in Katsura-uri (Cucumis melo var. conomon)2015
Author(s)
Nakamura Y, Sasaki A, Takeda K, Watanabe S, Shirota K, Suetome N, Park EY, Sato K, Okamoto S, Matsuo T
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Journal Title
Proceedings of the international symposium on quality management of fruits and vegetables for human health
Volume: 1
Pages: 123-126
Related Report
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[Presentation] Novel application of Katsura-uri fruit (Cucumis melo var. conomon) in differentiation-inducing, antimutagenic, and antioxidative effects of sulfur-containing fragrant ingredients2015
Author(s)
Yasushi Nakamura, Azusa Sasaki, Tomoaki Matsuo, Koji Shirota, Noboru Suetome, Eun Young Park, Kenji Sato, Shigehisa Okamoto
Organizer
12th Asian Congress of Nutrition
Place of Presentation
Yokohama, Japan
Year and Date
2015-05-14 – 2015-05-17
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