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Cancer prevention, suppression of exercise-fatigue, and application for diabetic patients of heirloom vegetables in Kyoto

Research Project

Project/Area Number 24300253
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKyoto Prefectural University

Principal Investigator

NAKAMURA YASUSHI  京都府立大学, 生命環境科学研究科(系), 教授 (90285247)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Shigehisa  鹿児島大学, 農学部, 准教授 (30211808)
IMAI Toshio  独立行政法人国立がん研究センター, 動物実験支援施設, 支援施設長 (20342884)
AOI Wataru  京都府立大学, 生命環境科学研究科, 助教 (60405272)
TOKUDA Harukuni  金沢大学, 医学研究科, 客員准教授 (60111960)
KOBAYASHI Yukiko  京都府立大学, 生命環境科学研究科, 助教 (10381930)
KUBO Yasuyuki  京都府立大学, 生命環境科学研究科, 教授 (80183797)
MATSUO Tomoaki  鹿児島大学, 農学部, 名誉教授 (90041673)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords京野菜 / 伝統野菜 / 桂ウリ / がん / 運動 / 疲労 / 糖尿病 / 炭疽病菌 / 食品機能性 / 癌 / ウリ / 炭疽病 / 野菜
Outline of Final Research Achievements

1. Methylthio acetic acid (MTA), a fragrant ingredient of Katsura-uri (Japanese pickling melon; Cucumis melo var. conomon) induced differentiation in human colon cancer cells with silencing effect of cyclinE2 gene, but did not alter a frequency of methylation of its transcriptional regulatory sequence. 2. Oral administration of MTA suppressed skin cancer (DMBA-TPA-induced) in ICR mice and mammary cancer (DMBA-induced) in Zucker rats. 3. Oral administration of MTA suppressed exercise-induced muscular fatigue with prevention of muscle acidification in ICR mice. 4. Novel application of Katsura-uri was developed for free from raising a blood glucose level in healthy human and diabetic patients. 5. Colletotrichum species were identified to be responsible bacteria that can occur black spots on the surface of fully ripened Katsura-uri fruit.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] The effect of Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon) and its derived ingredient 3-methylthioacetic acid on energy metabolism during prolonged exercise2015

    • Author(s)
      Aoi W, Takeda K, Sasaki A, Hasegawa Y, Nakamura Y, Park EY, Sato K, Iwasa M, Nakayama A, Minamikawa M, Kobayashi Y, Shirota K, Suetome N
    • Journal Title

      SpringerPlus

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antimutagenic, differentiation-inducing, and antioxidative effects of fragrant ingredients in Katsura-uri (Cucumis melo var. conomon)2015

    • Author(s)
      Nakamura Y, Sasaki A, Takeda K, Watanabe S, Shirota K, Suetome N, Park EY, Sato K, Okamoto S, Matsuo T
    • Journal Title

      Proceedings of the international symposium on quality management of fruits and vegetables for human health

      Volume: 1 Pages: 123-126

    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel application of Katsura-uri fruit (Cucumis melo var. conomon) in differentiation-inducing, antimutagenic, and antioxidative effects of sulfur-containing fragrant ingredients2015

    • Author(s)
      Yasushi Nakamura, Azusa Sasaki, Tomoaki Matsuo, Koji Shirota, Noboru Suetome, Eun Young Park, Kenji Sato, Shigehisa Okamoto
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-05-14 – 2015-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発がん性後期段階生成物に対する京伝統野菜桂ウリのがん予防作用2014

    • Author(s)
      中村考志,青井渉,朴恩栄,佐藤健司,城田浩治,末留昇,松尾友明,岡本繁久,重田友明,今井俊夫,鈴木信孝,徳田春邦
    • Organizer
      第19回日本フードファクター学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生体内発現発がん物質に対する桂ウリのがん予防作用2014

    • Author(s)
      中村考志,青井渉,朴恩栄,佐藤健司,城田浩治,末留昇,松尾友明,岡本繁久,重田友明,今井俊夫,鈴木信孝,徳田春邦
    • Organizer
      第17回日本補完代替医療学会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 桂ウリの成熟による成分変化とそれを活かした糖尿病患者への適用2014

    • Author(s)
      佐々木梓沙,中村考志,朴恩榮,佐藤健司,城田浩治,末留昇
    • Organizer
      日本栄養・食糧学会第53回近畿支部大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 伝統食用素材,桂ウリの後期段階生成物誘発発がんに対する抑制作用2014

    • Author(s)
      中村考志,青井渉,朴恩栄,佐藤健司,城田浩治,末留昇,松尾友明,岡本繁久,重田友明,今井俊夫,鈴木信孝,徳田春邦
    • Organizer
      第21回日本がん予防学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 京野菜桂ウリに含有するがん予防作用物質の探索2013

    • Author(s)
      中村考志
    • Organizer
      第20回日本がん予防学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] (Methylthio)acetic acid in Japanese picling melon as a potential chemopreventive agent against in vitro and in vivo carcinogenesis system2013

    • Author(s)
      徳田春邦
    • Organizer
      American Society of Pharmacognocy
    • Place of Presentation
      St. Louis, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Antimutagenic, differentiation-inducing, and antioxidative effects of fragrant ingredients in Katsura-uri (Cucumis melo var. conomon)2013

    • Author(s)
      中村考志
    • Organizer
      The International Symposium on Quality Management of Fruits and Vegetables for Human Health
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Annual Research Report
  • [Presentation] 京野菜桂ウリに含有するがん予防作用物質の探索2013

    • Author(s)
      中村考志
    • Organizer
      第18回日本フードファクター学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 京野菜桂ウリに含有するがん予防作用物質の探索2013

    • Author(s)
      中村考志
    • Organizer
      第16回日本補完代替医療学会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] 京野菜の桂ウリの摂取により得られるメチルチオ酢酸の発がん抑制効果2012

    • Author(s)
      武田和哉
    • Organizer
      日本補完代替医療学会
    • Place of Presentation
      京王プラザホテル (東京都)
    • Year and Date
      2012-11-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 京伝統野菜桂ウリの発がん抑制作用2012

    • Author(s)
      徳田春邦
    • Organizer
      第17回日本フードファクター学会
    • Place of Presentation
      静岡県男女共同参画センター・あざれあ(静岡市)
    • Year and Date
      2012-11-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 桂ウリ果実の香気成分によるヒト大腸がん細胞分化誘導作用2012

    • Author(s)
      佐々木梓沙
    • Organizer
      がん予防学会
    • Place of Presentation
      じゅうろくプラザ(岐阜市)
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス皮膚二段階発がんモデルにおけるメチルチオ酢酸の発がん抑制作用2012

    • Author(s)
      武田和哉
    • Organizer
      がん予防学会
    • Place of Presentation
      じゅうろくプラザ(岐阜市)
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
  • [Remarks] 食べて健康!京野菜(京野菜機能性連絡協議会)

    • URL

      http://kenko-kyoyasai.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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