| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
We previously demonstrated that S-(2-succinyl)cysteine(2SC) is generated by the reaction between cysteine and fumarate in adipocytes under hyperglycemic conditions. In the present study, we established the measurement system of 2SC in order to evaluate the mitochondrial disorders without tissue destruction. As results, 2SC was detected not only in serum but also in solid tissues such as hair and nail. Especially 2SC was detectable with 5 microL serum that was obtained from the blood collection from the fingertip. Serum 2SC was increased by the pathogenesis of kidney failures, patients in hypercholesteremia, and people who do not eat vegetables.
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