Investigation of optimal nutritional balance based on the inhibition of S-(2-succinyl) cysteine (2SC), post-translational modification by fumarate
Project/Area Number |
24300260
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits, studies on eating habits
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Research Institution | Tokai University |
Principal Investigator |
NAGAI Ryoji 東海大学, 農学部, 准教授 (20315295)
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Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Yukio 熊本大学, 生命科学研究科, 講師 (70452886)
ARAKI Tomohiro 東海大学, 農学部, 教授 (20193071)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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Keywords | 翻訳後修飾 / 脂肪細胞 / 生活習慣病 / フマル酸 / 糖尿病 / メタボリックシンドローム |
Outline of Final Research Achievements |
We previously demonstrated that S-(2-succinyl)cysteine(2SC) is generated by the reaction between cysteine and fumarate in adipocytes under hyperglycemic conditions. In the present study, we established the measurement system of 2SC in order to evaluate the mitochondrial disorders without tissue destruction. As results, 2SC was detected not only in serum but also in solid tissues such as hair and nail. Especially 2SC was detectable with 5 microL serum that was obtained from the blood collection from the fingertip. Serum 2SC was increased by the pathogenesis of kidney failures, patients in hypercholesteremia, and people who do not eat vegetables.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Mangosteen pericarp extract inhibits the formation of pentosidine and ameliorates skin elasticity2015
Author(s)
Ohno R, Moroishi N, Sugawa H, Maejima K, Saigusa M, Yamanaka M, Nagai M, Yoshimura M4, Amakura Y, Nagai R
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 57
Issue: 1
Pages: 27-32
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Ovalbumin modified with pyrraline, a Maillard reaction product, shows enhanced T-cell immunogenicity.2014
Author(s)
(130) Heilmann M, Wellner A, Gadermaier G, Ilchmann A, Briza P, Krause M, Nagai R,Burgdorf S, Scheurer S, Vieths S, Henle T, Toda M.
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Journal Title
J Biol Chem.
Volume: 289(11)
Issue: 11
Pages: 7919-7928
DOI
Related Report
Peer Reviewed
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[Journal Article] Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation.2014
Author(s)
Jo-Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T, Shirakawa J, Nagai R, Miyata T, Nagano T, Hirata Y, Inagi R, Nangaku M.
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Journal Title
Aging Cell
Volume: Epub ahead of print
Issue: 3
Pages: 519-28
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] マンゴスチンによるペントシジン生成抑制作用の検討2014
Author(s)
大野礼一、諸石成美、須川日加里、織畠郁也、田川智也、三枝武蔵、前嶋一宏、永井竜児
Organizer
第8回レドックス・ライフイノベーション第170委員会
Place of Presentation
宮崎シーガイヤコンベンションセンター 宮崎県宮崎市山崎町
Year and Date
2014-08-22
Related Report
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