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Studies for evaluation of effects of low-dose irradiation on higher brain and autonomic nervous activities in vertebrate development

Research Project

Project/Area Number 24310039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionThe University of Tokyo

Principal Investigator

ODA Shoji  東京大学, 新領域創成科学研究科, 准教授 (50266714)

Co-Investigator(Kenkyū-buntansha) HISATSUNE Tatsuhiro  東京大学, 大学院新領域創成科学研究科, 准教授 (10238298)
Co-Investigator(Renkei-kenkyūsha) MITANI Hiroshi  東京大学, 大学院新領域創成科学研究科, 教授 (70181922)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords放射線被ばく / メダカ / マウス / 自律神経 / 心拍 / 高次脳機能 / 遊泳軌跡 / 低線量 / 放射線影響 / メダカ行動 / メダカ心拍 / 低線量照射 / ストレス / 低線量被ばく / 低線量放射線 / 概日リズム / バースト遊泳
Outline of Final Research Achievements

Restriction of adult medaka with anesthesia befor irradiation decreased medaka's heart rate much more than sub-lethal dose irradiation of carbon ion beam, indicating that the effects of low dose irradiation upon the autonomic nervous activity regulating heart beating in medaka are very little and can be ignored. Effects by chronic irradiation is not examined and must be addressed in future. Irradiation of mouse head with high-dose gamma rays (10 Gy) induced transient cognitive impairment. The methods to digitalize tracks of swimming adults and fries of medaka and the protocols to irradiate medaka chronically with ultra-low dose rate (about 2 microSv/hour) have been established in this study, however, the planed low- and ultra-low irradiation experiments on medaka has not conducted yet and remained to be our task in near future.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (16 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Global Analysis of Medaka by Whole Body Histology and 24-Hours Tracking.2014

    • Author(s)
      Oda S., Nishimaki T., Katsumura T., Katada Y., Oga A., Ikemoto K., Taniguchi Y., Oota H.
    • Journal Title

      Cytometry Research

      Volume: 24 Pages: 9-14

    • NAID

      130006832390

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nuclear and cytoplasmic changes in erythrocytes of p53-deficient medaka fish (Oryzias latipes) after exposure to gamma-radiation.2014

    • Author(s)
      Sayed, A. E., S. Oda and H. Mitani
    • Journal Title

      Mutat Res Genet Toxicol Environ Mutagen

      Volume: 771 Pages: 64-70

    • DOI

      10.1016/j.mrgentox.2014.01.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regular heartbeat rhythm at the heartbeat initiation stage is essential for normal cardiogenesis at low temperature.2014

    • Author(s)
      Watanabe-Asaka, T., Y. Sekiya, H. Wada, T. Yasuda, I. Okubo, S. Oda and H. Mitani
    • Journal Title

      BMC Dev Biol

      Volume: 14 Issue: 1 Pages: 12-12

    • DOI

      10.1186/1471-213x-14-12

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] p53-Dependent suppression of genome instability in germ cells.2014

    • Author(s)
      Otozai S, Ishikawa-Fujiwara T, Oda S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, Todo T.
    • Journal Title

      Mutat Res,

      Volume: 760 Pages: 24-32

    • DOI

      10.1016/j.mrfmmm.2013.12.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regular heartbeat rhythm at the heartbeat initiation stage is essential for normal cardiogenesis at low temperature2014

    • Author(s)
      Tomomi Watanabe-Asaka, Yoshio Sekiya, Hironori Wada, Takako Yasuda, Ikuya Okubo, Shoji Oda, and Hiroshi Mitani
    • Journal Title

      BMC Developmental Biology

      Volume: 14 Pages: 12-24

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] メダカ系統の行動解析に向けた遊泳軌跡生成手法2014

    • Author(s)
      小野瑛人、高橋悟、川端邦明、尾田正二、金子俊一
    • Organizer
      ViEW2014
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] GroupTracker: A Video tracking system for analysis of social behaviors in a medaka school.2014

    • Author(s)
      Tsukasa Fukunaga, Shoko Kubota, Shoji Oda, Wataru Iwasaki
    • Organizer
      第20回小型魚類研究会
    • Place of Presentation
      慶應義塾大学薬学部(芝共立キャンパス)
    • Year and Date
      2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] メダカ心拍変動は交感神経と副交感神経の制御を受けている2013

    • Author(s)
      浅香智美, 尾田正二, 新堀真希, 岩崎賢一, 寺田昌弘, 馬場昭次
    • Organizer
      日本生理学会
    • Place of Presentation
      タワーホール船堀, 東京都
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] メダカの瞳孔の研究2013

    • Author(s)
      内木場寛明、三谷啓志、尾田正二
    • Organizer
      日本動物学会 第84回岡山大会
    • Place of Presentation
      岡山 岡山大学津山キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロビームを用いた精巣選択的照射のメダカ生体への影響2013

    • Author(s)
      尾田正二、保田隆子、浅香智美、三谷啓志、池田裕子、武藤泰子、横田裕一郎 、鈴木芳代 、舟山知夫 、小林泰彦
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森 ホテルクラウンパレス青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカの体と動きを丸ごと全部数値化する研究2013

    • Author(s)
      尾田正二、浅香智美、保田隆子、三谷啓志、谷口善仁、太田博樹、勝村啓史、西槙俊之、埴原恒彦
    • Organizer
      第23回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京 日本医科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regular heartbeat rhythm at heartbeat initiation stage is essential for normal cardiogenesis2013

    • Author(s)
      Tomomi Watanabe-Asaka, Yoshio Sekiya, Hironori Wada, Ikuya Okubo, Shoji Oda, Hiroshi Mitani
    • Organizer
      8th European Zebrafish Meeting
    • Place of Presentation
      バルセロナ、スペイン
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカの心臓自律神経の研究2013

    • Author(s)
      浅香智美、尾田正二、岩崎賢一、馬場昭次、三谷啓志
    • Organizer
      日本動物学会 第84回岡山大会
    • Place of Presentation
      岡山 岡山大学津山キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカにおける高密度ストレスが行動に与える影響2012

    • Author(s)
      矢野裕紀, 高橋英也, 坂本竜哉, 三谷啓志, 尾田正二
    • Organizer
      日本動物学会
    • Place of Presentation
      大阪大学, 大阪市
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高速度映像を用いたメダカ心臓自律神経系に対する放射線影響評価の検討2012

    • Author(s)
      浅香智美
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      東北大学, 仙台市
    • Year and Date
      2012-09-06
    • Related Report
      2012 Annual Research Report
  • [Remarks] 動物生殖システム分野

    • URL

      http://park.itc.u-tokyo.ac.jp/K-medaka/TOP.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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