Studies for evaluation of effects of low-dose irradiation on higher brain and autonomic nervous activities in vertebrate development
| Project/Area Number |
24310039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ODA Shoji 東京大学, 新領域創成科学研究科, 准教授 (50266714)
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| Co-Investigator(Kenkyū-buntansha) |
HISATSUNE Tatsuhiro 東京大学, 大学院新領域創成科学研究科, 准教授 (10238298)
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| Co-Investigator(Renkei-kenkyūsha) |
MITANI Hiroshi 東京大学, 大学院新領域創成科学研究科, 教授 (70181922)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 放射線被ばく / メダカ / マウス / 自律神経 / 心拍 / 高次脳機能 / 遊泳軌跡 / 低線量 / 放射線影響 / メダカ行動 / メダカ心拍 / 低線量照射 / ストレス / 低線量被ばく / 低線量放射線 / 概日リズム / バースト遊泳 |
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| Outline of Final Research Achievements |
Restriction of adult medaka with anesthesia befor irradiation decreased medaka's heart rate much more than sub-lethal dose irradiation of carbon ion beam, indicating that the effects of low dose irradiation upon the autonomic nervous activity regulating heart beating in medaka are very little and can be ignored. Effects by chronic irradiation is not examined and must be addressed in future. Irradiation of mouse head with high-dose gamma rays (10 Gy) induced transient cognitive impairment. The methods to digitalize tracks of swimming adults and fries of medaka and the protocols to irradiate medaka chronically with ultra-low dose rate (about 2 microSv/hour) have been established in this study, however, the planed low- and ultra-low irradiation experiments on medaka has not conducted yet and remained to be our task in near future.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] p53-Dependent suppression of genome instability in germ cells.2014
Author(s)
Otozai S, Ishikawa-Fujiwara T, Oda S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, Todo T.
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Journal Title
Mutat Res,
Volume: 760
Pages: 24-32
DOI
Related Report
Peer Reviewed
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