Development of long-term bystander imaging system using heavy-ion microbeam
| Project/Area Number |
24310073
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Quantum beam science
|
|---|
| Research Institution | Japan Atomic Energy Agency |
|---|
Principal Investigator |
Funayama Tomoo 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門・量子ビーム応用研究センター, 研究主幹 (40354956)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
|
|---|
| Keywords | 量子ビーム医療応用 / 重イオンビーム / マイクロビーム / バイスタンダー効果 / 低線量放射線影響 |
|---|
| Outline of Final Research Achievements |
To explore the molecular mechanisms of heavy-ion induced bystander effect, a system for long-term live imaging of microbeam-irradiated cell sample was developed. As a first step, I developed a software framework for developing multiple software for different experimental purpose. Using the framework, a novel cell targeting software was build, which enables integrated sample irradiation with focusing heavy-ion microbeam. This software enabled a rapid and accurate irradiation of targeted cells with focusing heavy-ion microbeam. Thereafter, I developed software libraries for long-term real-time autofocusing and automatic imaging of the target sample. Finally, these codes were integrated into the software framework to establish a long-term bystander imaging system.
|
Report
(5 results)
Research Products
(19 results)
-
-
-
-
-
-
-
-
[Presentation] Focusing Heavy-ion Microbeam System of JAEA-Takasaki2015
Author(s)
Tomoo Funayama, Yuichiro Yokota, Tetsuya Sakashita, Michiyo Suzuki, Yasuhiko Kobayashi
Organizer
The 12 th International Workshop on Microbeam Probes of Cellular Radiation Response
Place of Presentation
The Wakasa Wan Energy Research Center (Tsuruga, Fukui, Japan)
Year and Date
2015-05-31
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
