| Project/Area Number |
24310074
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Quantum beam science
|
|---|
| Research Institution | Japan Atomic Energy Agency |
|---|
Principal Investigator |
FUJII Kentaro 独立行政法人日本原子力研究開発機構, 原子力科学研究部門 先端基礎研究センター, 研究副主幹 (00360404)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AKIMITSU Nobuyoshi 東京大学, アイソトープ総合センター, 教授 (40294962)
FUJII Shin-ichiro 独立行政法人産業技術総合研究所, 計測標準研究部門, 主任研究員 (10415739)
KATO Dai 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (80533190)
TSUKIMOTO Mitsutoshi 東京理科大学, 薬学部, 講師 (70434040)
NARITA Ayumi 独立行政法人産業技術総合研究所, 省エネルギー研究部門, 産総研特別研究員 (50633898)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOKOYA Akinari 独立行政法人日本原子力研究開発機構, 原子力科学研究部門・先端基礎研究センター, 研究主席 (10354987)
NIWA Osamu 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 総括研究主幹 (70392644)
KOJIMA Syuji 東京理科大学, 薬学部, 嘱託教授 (90119579)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
|---|
| Keywords | 放射光 / 軟X線 / ATP / 生物効果 / 分子変化 |
|---|
| Outline of Final Research Achievements |
ATP(Adenosine tri-phosphate), one of ribonucleic acids, acts as an intra-cellular energy transfer. ATP is also used as a substrate to synthesize messenger RNA and as a ligand of inter-celular signaling. Damaged ATP produced by synchrotron soft X-rays might act as down- or up-regulation of these biological function. In this study, we examined the relation between molecular damage of ATP and its biological activity using various biological assesments, such as energy donor activity, genetic information transfer, adn inter-cellular signaling activity. The obtained results suggest that the altered ATP molecule might contribute the induction of changing of a radiation sensitivity of cancer cells.
|
