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Basic research for early diagnosis and therapy of Alzheimer disease with nanoparticles and compounds that promotes/inhibits aggregation of amyloid beta peptide

Research Project

Project/Area Number 24310102
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Microdevices/Nanodevices
Research InstitutionShimane University

Principal Investigator

NAGAI Atsushi  島根大学, 医学部, 教授 (40273940)

Co-Investigator(Kenkyū-buntansha) SK Abdullah MD (SHEIKH Abdullah Mohammad)  島根大学, 医学部, 助教 (30403447)
SHIOTA Yuri  島根大学, 医学部, 助教 (10581415)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsアルツハイマー病 / アミロイドベータ(Aβ) / フタロシアニン / lysophosphatidylcholine / 近赤外線 / 神経細胞死 / アミロイドβ(Aβ) / アポトーシス / ナノ粒子 / Lysophosphatidylcholine / メタボローム解析 / アミロイド / β蛋白 / MALDI-TOF-MS
Outline of Final Research Achievements

We have detected lysophosphatidylcholine (LPC) as a compound that promotes amyloid beta aggregation through increase of oligomerization. On the other hand, detected phthalocyanine as a nano particle that inhibits amyloid beta aggregation, which decrease hydrophobicity and beta-sheet conformational change. The compound has no toxicity to neuronal culture and rat, leading to the possibility for therapeutic application. We produced and examined the new phthalocyanine derivatives for non-invasive near infrared ray-diagnosis of Alzheimer disease (AD) because they have high affinity to amyloid beta deposited in AD brains.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (34 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (25 results)

  • [Journal Article] A carboxylated Zn-phthalocyanine inhibits fibril formation of Alzheimer’s amyloid β peptide.2015

    • Author(s)
      Tabassum S, Sheikh AM, Yano S. Ikeue T, Handa M, Nagai A
    • Journal Title

      FEBS J

      Volume: 282 Issue: 3 Pages: 463-476

    • DOI

      10.1111/febs.13151

    • NAID

      120006309236

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of arrhythmogenic right ventricular cardiomyopathy in a 70-year-old patient.2014

    • Author(s)
      Nitta E, Yoshitomi H, Sugamori T, Fukuma A, Shibata H, Adachi T, Ito S, Takahashi N, Nagai A, Tanabe K
    • Journal Title

      J Med Ultrasonics

      Volume: 41 Issue: 1 Pages: 73-76

    • DOI

      10.1007/s10396-013-0455-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma arginine/ADMA ratio as sensitive risk marker for atherosclerosis: Shimane CoHRE study.2014

    • Author(s)
      Notsu Y, Yano S, Shibata H, Nagai A, Nabika T
    • Journal Title

      Atherosclerosis

      Volume: 239 Pages: 61-66

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Uremic Toxin p-Cresol on Proliferation, Apoptosis, Differentiation, and Glucose Uptake in 3T3-L1 Cells.2014

    • Author(s)
      Tanaka S, Yano S, Sheikh AM, Nagai A, Sugimoto T
    • Journal Title

      Artif Organs

      Volume: 印刷中 Issue: 7 Pages: 566-571

    • DOI

      10.1111/aor.12252

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact 5 SNPs in dopamine-related genes on executive function.2013

    • Author(s)
      Mitaki S, Isomura M, Maniwa K, Yamasaki M, Nagai A, Nabika T, Yamaguchi S
    • Journal Title

      Acta Neurologica Scandinavica

      Volume: 127 Pages: 70-79

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Hemagglutination Inhibition Assay and Enzyme Immunoassay for Determination of Mumps and Rubella Immune Status in Health Care Personnel.2013

    • Author(s)
      Kumakura S, Shibata H, Isobe T, Hirose M, Ohe M, Nishimura N, Onoda K, Nagai A, Yamaguchi S
    • Journal Title

      J Clin Lab Anal

      Volume: 27 Pages: 418-421

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human mesenchymal stem cell-transplantation changes proinflammatory gene expression through NF-kB-dependent pathway in a rat focal cerebral ischemic model.2013

    • Author(s)
      Wang H, Nagai A, Sheikh AM, Liang XY, Yano S, Mitaki S, Ishibashi Y, Kobayashi S, Kim S, Yamaguchi S
    • Journal Title

      J Neurosci Res

      Volume: 91 Pages: 1440-1449

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Vulnerability of Hippocampal CA1 Neurons to Hypoperfusion in Ataxia and Male Sterility (AMS) Mouse.2013

    • Author(s)
      Liang XY
    • Journal Title

      Brain Research

      Volume: 1, 494(Epub 2012 Dec 3.) Pages: 109-117

    • DOI

      10.1016/j.brainres.2012.11.046

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of a complement fixation assay and enzyme immunoassay to determine the seroprevalence of measles and varicella in a survey of healthcare workers.2013

    • Author(s)
      Shibata H
    • Journal Title

      J int Med Res

      Volume: 41(Epub 2013 Jan 23.) Issue: 1 Pages: 224-230

    • DOI

      10.1177/0300060512474773

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] アトピー性皮膚炎治療におけるTARC(thymus and activation-regulated chemokine)測定の有用性.2014

    • Author(s)
      陶山洋二, 野津吉友, 三島清司, 長井 篤
    • Organizer
      第61回日本臨床検査医学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト血管平滑筋細胞のアポトーシスと石灰化形成に関する検討.2014

    • Author(s)
      長崎雅幸, 矢野彰三, 松本健一, 織田禎一, 原田祐治, 三島清司, 長井 篤
    • Organizer
      第61回日本臨床検査医学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] アルツハイマー病におけるフィードバック関連陰性電位の変化.2014

    • Author(s)
      新田江里, 山口修平, 小野田慶一, 石飛文規, 岡﨑亮太, 三島清司, 長井 篤
    • Organizer
      第44回日本神経生理学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] LAMP法を用いたサイトメガロウイルスβ2.7mRNA検査法の確立への取り組み.2014

    • Author(s)
      松田親史, 渕田比呂志, 三島清司, 長井 篤
    • Organizer
      日本臨床検査自動化学会第46回大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] LC-MS/MSによるキヌレニン関連物質の分析2014

    • Author(s)
      馬庭恭平, 塩田由利, 山田和夫, 岩上有里加, 野津吉友, 三島清司, 並河 徹, 長井篤
    • Organizer
      日本臨床検査自動化学会第46回大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Acaboxylated Zn-phthalocyanine inhibits the fibril formation of Alzheimer’s amyloid β peptide2014

    • Author(s)
      Nagai A
    • Organizer
      2nd International Conference on Alzheimer’s Disease & Dementia
    • Place of Presentation
      Valencia Spain
    • Year and Date
      2014-09-23 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] LC-MS/MSによる酸化ストレスマーカー、ADMA・キヌレニン関連物質の一斉分析.2014

    • Author(s)
      塩田由利, 山田和夫, 馬庭恭平, 岩上有香里, 並河 徹, 長井 篤
    • Organizer
      第54回日本臨床化学会年次学術集会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腎・心血管障害進展指標としてのArginine/ADMA比の有用性: Shimane CoHRE Study.2014

    • Author(s)
      野津吉友, 矢野彰三, 長井 篤, 並河 徹
    • Organizer
      第54会日本臨床化学会年次学術集会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 頸動脈内膜中膜複合厚と骨代謝マーカーとの関連(Shimane CoHRE Study).2014

    • Author(s)
      矢野彰三, 並河 徹, 杉本利嗣, 長井 篤
    • Organizer
      第54会日本臨床化学会年次学術集会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] The relationships of NPY gene polymorphism (rs5574,rs16147)with blood pressure and stress.2014

    • Author(s)
      Matsuda C、Isomura M、Mishima S、Nabika T、Nagai A
    • Organizer
      第63回日本医学検査学会
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター他
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 無症候性微小脳出血は脳ネットワークの機能的分離を悪化させる.2014

    • Author(s)
      門田勝彦, 小野田慶一, 中川知憲, 高吉宏幸, 長井 篤, 小黒浩明, 山口修平
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場他
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 健常成人における脈圧と認知機能低下および海馬萎縮の関連.2014

    • Author(s)
      水原 亮, 山口拓也, 中川知憲, 高吉宏幸, 長井 篤, 小黒浩明, 山口修平
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場他
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 無症候性脳病変に対する慢性腎臓障害および危険因子重畳の影響.2014

    • Author(s)
      食見花子, 豊田元哉, 三瀧真吾, 小野田慶一, 小黒浩明, 長井 篤, 卜藏浩和, 山口修平
    • Organizer
      第55回日本神経学会学術大会,
    • Place of Presentation
      福岡国際会議場他
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of optic nerve head morphology parameters between subjects with and without silent brain infarction.2014

    • Author(s)
      Hara K, Tanito M, Sano I, Onoda K, Oguro H, Nagai A, Yamaguchi S, Hamano T, Shiwaku K, Ohira A
    • Organizer
      WOC2014
    • Place of Presentation
      東京国際フォーラム、帝国ホテル
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 間葉系幹細胞移植は脳卒中モデルラットにおいてNF-kB経路抑制を介して症状を改善させる.2014

    • Author(s)
      Shikh AM, 長井 篤,  王 暉, 矢野彰三, 三瀧 真悟, 小林祥泰, 山口修平
    • Organizer
      STROKE2014
    • Place of Presentation
      (大阪)大阪国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] アンチエージングマーカーと脈波伝播速度(PWV), 頸動脈IMT,無症候性脳虚血との関連.2013

    • Author(s)
      小黒浩明, 三瀧真悟, 中川知憲, 高吉宏幸, 長井 篤, 山口修平
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      (東京)東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] ニューロペプタイドY遺伝子多型と喫煙の関係2013

    • Author(s)
      松田親史,陶山洋二,野津吉友,柴田 宏,長井 篤,磯村 実,並河 徹
    • Organizer
      第62回日本医学検査学会
    • Place of Presentation
      (高松)サンポートホール高松ほか
    • Related Report
      2013 Annual Research Report
  • [Presentation] 2006年と2011年に分離したMRSAにおける抗MRSA薬MIC値の比較2013

    • Author(s)
      谷口由紀,松田親史,竹内志津枝,柳楽 槙,森山英彦,柴田 宏,長井 篤
    • Organizer
      第62回日本医学検査学会
    • Place of Presentation
      (高松)サンポートホール高松ほか
    • Related Report
      2013 Annual Research Report
  • [Presentation] Relationship between glucose metabolism and undercarboxylated osteocalcin : cross-sectional study in cmmunity-dwelling population (Shimane Cmmunity-based Health Research and Education, COHRE Study).2012

    • Author(s)
      Yano S
    • Organizer
      ASBMR2012 Annual Meeting
    • Place of Presentation
      Minneapolis, Minnesota USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドパミン 神経伝達に関与する一遺伝子多型と前頭葉機能の関連2012

    • Author(s)
      三瀧真悟
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 虚血ラットへの骨髄間葉系幹細胞移植効果 : 虚血境界域グリアの遺伝子発現2012

    • Author(s)
      王暉
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際ホーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transplantation of Human Mesenchymal Stem Cells to a Rat Focal Cerebral Ischemic Model Changes the Expressions in ED1+ or Iba1+cells.2012

    • Author(s)
      Wang H
    • Organizer
      VAS-COG Japan 2012 (第3回日本血管性認知障害研究会)
    • Place of Presentation
      東京ステーションコンファランス(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一過性脳虚血AMSマウスの海馬CA1ニューロン脆弱性と参加ストレス調節2012

    • Author(s)
      梁雪云
    • Organizer
      第53回日本神経病理学会学術研究会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中大脳動脈閉塞モデルラット脳内アクアポリン4、9発現に及ぼすfasudilの効果2012

    • Author(s)
      Sheikh AM
    • Organizer
      第30回日本神経治療学会総会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 動脈硬化指標としてのArginine/ADMA比の有用性 : Shimane CoHRE Study.2012

    • Author(s)
      野津吉友
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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