Development of the novel determination methodology for absolute configuration without theoretical calculation
| Project/Area Number |
24310151
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Hokkaido University |
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Principal Investigator |
MONDE Kenji 北海道大学, 先端生命科学研究科(研究院), 教授 (40210207)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Tohru 北海道大学, 先端生命科学研究院, 助教 (00587123)
MURAI Yuta 北海道大学, 先端生命科学研究院, 助教 (20707038)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | VCD / 絶対配置 / 励起き子 / キラリティー / カルボニル / 励起子 / 非経験的 / コンフォメーション / 角度依存性 |
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| Outline of Final Research Achievements |
Vibrational circular dichroism (VCD) is a reliable and non-empirical method which can determine absolute configuration. However, ab initio theoretical calculation for its conformational analysis of a target molecule is essential. In this project, a new methodology for determination of absolute configuration without its theoretical calculation has been developed by utilizing a huge bisignate VCD signal caused by their interaction of two IR functional groups such as carbonyl groups in a target molecule.
This novel methodology named as “VCD exciton chirality method” has been applied to a variety of carbohydrates, steroids, complex natural products, acyclic biological active lipids, and poly lactic acid as a polymer, which shows its high applicability.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Revision of the relative and absolute stereochemistry of 3-hydroxydehydroiso-α-lapachone and its derivatives.2014
Author(s)
Khandelwal, P., Singh, P., Taniguchi, T., Monde, K., Johmoto, K., Uekusa, H., Masubuti, H., Fujimoto, Y.
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Journal Title
Phytochemistry Lett.
Volume: 10
Pages: 224-229
DOI
Related Report
Peer Reviewed
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[Journal Article] Enantioselective intramolecular aza-spiroannulation onto benzofurans using chiral rhodium catalysis2014
Author(s)
Shibuta, T., Sato, S., Shibuya, M., Kanoh, N., Taniguchi, T., Monde, K., Iwabuchi, Y.
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Journal Title
Heterocycles
Volume: 89
Issue: 32
Pages: 631-639
DOI
Related Report
Peer Reviewed
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[Presentation] Exciton Chirality Method in VCD2013
Author(s)
Tohru Taniguchi; Daisuke Manai; Takahiro Hongen; Kenji Monde
Organizer
International Conference on Chiroptical Spectroscopy
Place of Presentation
Student Life center, Vanderbilt University (USA)
Related Report
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