Bioactive substances from marine cyanobacteria
| Project/Area Number |
24310160
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERUYA Toshiaki 琉球大学, 教育学部, 准教授 (90375428)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Osamu 慶應義塾大学, 理工学部, 助教 (20436992)
MIYAMOTO Kenji 慶應義塾大学, 理工学部, 准教授 (60360111)
HIRATA Kunio 理化学研究所, 放射光科学総合研究センター, 技師 (20373524)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 海洋シアノバクテリア / ビセリングビアサイド / リポペプチド / 構造決定 / 全合成 / アポトーシス / 生物活性物質 / 化学合成 / 作用機構 / 結晶構造 / 腫瘍細胞増殖阻害 / トムルリン / 小胞体ストレス / クラハイン / ビセブロモアミド / 標的生体分子探索 / ビセリンビオライドA |
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| Outline of Final Research Achievements |
We could find a lot of novel bioactive substances such as biselyngbyolides A and B and kurahayne from marine cyanobacteria collected at Okinawa and Amami Islands in Kagoshima Prefecture. These compounds induced apoptosis based on their ER stress. Crystallization and structure determination of sacro-endoplasmic reticulum calcium ATPase (SERCA) complexed with biselyngbyaside and biselyngbyolide B were achieved. Biselyngbyasides bind to SERCA with unique binding mode. We achieved chemical synthesis of biselyngbyolides A and B.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Total Synthesis of Biselyngbyolide A.2014
Author(s)
Yurika Tanabe, Eisuke Sato, Naoya Nakajima, Akifumi Ohkubo, Osamu Ohno, and Kiyotake Suenaga
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Journal Title
Organic Letters, 16 (11), (2014).
Volume: 16
Pages: 2858-2861
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Fluorescent Aplyronine A: Intracellular Accumulation and Disassembly of Actin Cytoskeleton in Tumor Cells2012
Author(s)
Masaki Kita, Kozo Yoneda, Yuichiro Hirayama, Kota Yamagishi, Yuki Saito, Yuka Sugiyama, Yoshihiro Miwa, Osamu Ohno, Maho Morita, Kiyotake Suenaga, Hideo Kigoshi
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Journal Title
ChemBioChem
Volume: 13
Pages: 1754-1758
DOI
Related Report
Peer Reviewed
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