| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
We have developed Mukaiyama aldol reaction directly using esters. The three components, an ester, a silyl enolate, and a hydrosilane treated with indium triiodide to give the corresponding Mukaiyama aldol product. Indium triiodide accelerates the hydrosilation of esters and the addition of silyl enolates to resulted aldehydes. Various types of esters and silyl enolates were applicable to this reaction system. The use of amides instead of esters effectively provided aminocarbonyl compounds. In addition, we have revealed that a sequential addition of silyl cyanide and ketene silyl acetals to esters was achieved by a gallium trihalide catalyst to produce β-cyano-β-siloxy esters.
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