| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|
|---|
| Outline of Final Research Achievements |
We analyzed the physiological activity of bis (3'-5') cyclic diguanylic acid（c-di-GMP）and other cyclic dinucleotides having similar structure. Our results demonstrated the important bioactivity of c-di-GMP to inhibit the metastases of breast cancer and to attenuate experimental autoimmune encephalitis. During the immune response against cytosolic DNA, cyclic-GMP-AMP (cGAMP) was proposed to bind to an immunoreceptor called STING. Here we demonstrated that non-canonical cyclic dinucleotides 2',3'-cGAMP, which contains a single 2’-5’ phosphodiester bond, activated STING and induced the production of type I interferons.
These are valuable findings for the development of the research and our final goal ”invention of useful immunostimulator”.
|
