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Hollow microcapsules fabricated from ultrasonically generated microbubbles of cyanoacrylate instant adhesive

Research Project

Project/Area Number 24360066
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Fluid engineering
Research InstitutionYamagata University

Principal Investigator

MAKUTA TOSHINORI  山形大学, 理工学研究科, 准教授 (40451661)

Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Ichiro  山形大学, 大学院理工学研究科, 名誉教授 (50007217)
FUKAMI Tadanori  山形大学, 大学院理工学研究科, 准教授 (70333987)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywordsマイクロバブル / 超音波 / マイクロカプセル / 画像診断システム / ドラッグデリバリー / ナノカプセル
Outline of Final Research Achievements

We developed a new method for the fabrication of hollow microcapsule blowing the vapor of moisture curing polymer into water as microbubbles. The hollow microcapsules are composed of cyanoacrylate, a biocompatible material used for adhesion to human tissue such as skin, blood vessels, and organs. Moreover these are less than 10 um in diameter, which is smaller than a blood capillary (approximately 10 um). Therefore, with their stable polymer shells, the hollow microcapsules are possible ultrasound contrast agents, and are expected to be generated at low cost on the medical frontline.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (28 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) Book (3 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Hollow submicron spheres fabricated from cyanoacrylate instant adhesive2014

    • Author(s)
      Toshinori Makuta, Yuki Yoshihiro, Taichi Sutoh, Kazuma Ogawa
    • Journal Title

      Materials Letters

      Volume: 131 Pages: 310-312

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development and Optimization of a Microbubble Generator with a Hollow Cylindrical Ultrasonic Horn.2014

    • Author(s)
      Tatsuya Numakura, Kazuki Kashiwagura, Toshinori Makuta
    • Journal Title

      Journal of the Japanese Society for Experimental Mechanics

      Volume: 14

    • NAID

      130006386640

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acoustic Behavior of Cyanoacrylate Hollow Microcapsules Fabricated by Bubble Template Method2013

    • Author(s)
      Masaki SAKAGUCHI, Toshinori MAKUTA
    • Journal Title

      Journal of the Japanese Society for Experimental Mechanics

      Volume: 13 Issue: Special_Issue Pages: s41-s44

    • DOI

      10.11395/jjsem.13.s41

    • NAID

      10031189790

    • ISSN
      1346-4930, 1884-4219
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of the Bubble-Generating State on the Degradation of Indigo Carmine by Ultrasonically Generated Microbubbles2013

    • Author(s)
      Yuta Aizawa, Toshinori MAKUTA
    • Journal Title

      Journal of the Japanese Society for Experimental Mechanics

      Volume: 13 Issue: Special_Issue Pages: s51-s55

    • DOI

      10.11395/jjsem.13.s51

    • NAID

      10031189792

    • ISSN
      1346-4930, 1884-4219
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波振動を用いて作る中空マイクロカプセル2013

    • Author(s)
      幕田寿典
    • Journal Title

      超音波TECHNO

      Volume: 25 Pages: 93-97

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 超音波で発生させたマイクロバブルを用いて作る中空マイクロカプセル2013

    • Author(s)
      幕田寿典
    • Journal Title

      日本機械学会

      Volume: 116 Pages: 792-792

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Generating Bubbles, Diagnosing by Bubbles, and Treating with Bubble: From Generation of Ultrasonic Contrast Agent to Its Medical Application (1) Microbubble Generation Technique2013

    • Author(s)
      幕田寿典
    • Journal Title

      Medical Imaging Technology

      Volume: 31 Issue: 5 Pages: 325-329

    • DOI

      10.11409/mit.31.325

    • NAID

      130003395835

    • ISSN
      0288-450X, 2185-3193
    • Related Report
      2013 Annual Research Report
  • [Journal Article] Sonochemical reaction with microbubbles generated by hollow ultrasonic horn2013

    • Author(s)
      Toshinori Makuta, Yuta Aizawa, Ryodai Suzuki
    • Journal Title

      Ultrasonics Sonochemistry

      Volume: 20 Issue: 4 Pages: 997-1001

    • DOI

      10.1016/j.ultsonch.2012.12.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波を用いたマイクロバブル発生技術とその応用2013

    • Author(s)
      幕田寿典
    • Journal Title

      ケミカルエンジニヤリング

      Volume: 50 Pages: 6-16

    • Related Report
      2012 Annual Research Report
  • [Presentation] 超音波マイクロバブルを用いたシアノアクリレート中空粒子生成に関する研究2015

    • Author(s)
      須藤太一,吉弘裕基,幕田寿典
    • Organizer
      化学工学会第80年会
    • Place of Presentation
      芝浦工業大学
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超音波マイクロバブルで作るシアノアクリレート中空ナノ粒子に関する研究2014

    • Author(s)
      吉弘裕基,須藤太一,幕田寿典
    • Organizer
      化学工学会新潟大会2014
    • Place of Presentation
      新潟大学
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロバブルから直接作るシアノアクリレート中空微粒子に関する研究2014

    • Author(s)
      須藤太一,吉弘裕基,幕田寿典
    • Organizer
      日本機械学会2014年年次大会
    • Place of Presentation
      東京電機大学
    • Year and Date
      2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超音波中空ホーンによるマイクロバブル発生に及ぼす周波数およびガス出口形状の影響2014

    • Author(s)
      沼倉達矢, 幕田寿典
    • Organizer
      日本機械学会東北 学生会第44 回学生員卒業研究発表講演会
    • Place of Presentation
      山形県米沢市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 瞬間硬化性樹脂と超音波マイクロバブルから作る中空マイクロカプセルの薬剤輸送性2013

    • Author(s)
      坂口雅希, 須藤太一, 幕田寿典
    • Organizer
      日本機械学会東北学生会第43回学生員卒業研究発表講演会
    • Place of Presentation
      一関高専(岩手県)
    • Year and Date
      2013-03-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 超音波中空ホーンを用いた音響化学反応装置の開発2013

    • Author(s)
      相澤優太, 沼倉達矢, 幕田寿典
    • Organizer
      日本機械学会東北学生会第43回学生員卒業研究発表講
    • Place of Presentation
      一関高専(岩手県)
    • Year and Date
      2013-03-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Acoustic behavior and drug transportability of hollow microcapsules directly fabricated from microbubbles containing moisture curing resin2013

    • Author(s)
      Toshinori Makuta,Masaki Sakaguchi
    • Organizer
      International Conference on Multiphase Flow 2013
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Acoustic property and Yield Improvement of Ultrasonically Generated Cyanoacrylate Hollow Microcapsules2013

    • Author(s)
      Taichi Sutoh, Tadanori Fukami, Toshinori Makuta
    • Organizer
      8th ISEM’13 Sendai
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development and Optimization of a Microbubble Generator with a Hollow Cylindrical Ultrasonic Horn2013

    • Author(s)
      Tatsuya Numakura, Toshinori Makuta
    • Organizer
      8th ISEM’13 Sendai
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Acoustic Behavior of Cyanoacrylate Hollow Microcapsules Fabricated by Bubble Template Method2012

    • Author(s)
      Masaki Sakaguchi, Toshinori Makuta
    • Organizer
      ISEM-ACEM-SEM-7th ISEM'12 Taipei
    • Place of Presentation
      Grand Hotel (台北, 台湾)
    • Year and Date
      2012-11-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Degradation Process of Indigo Carmine with Microbubbles Generated from the Hollow Ultrasonic Horn2012

    • Author(s)
      Yuta Aizawa, Toshinori Makuta
    • Organizer
      ISEM-ACEM-SEM-7th ISEM'12 Taipei
    • Place of Presentation
      Grand Hotel (台北, 台湾)
    • Year and Date
      2012-11-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] 瞬間硬化性樹脂とマイクロバブルから作る中空マイクロカプセルの機能性検証2012

    • Author(s)
      坂口雅希, 幕田寿典
    • Organizer
      化学工学会第44回秋季大会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 超音波中空ホーンとマイクロバブルを用いたインジゴカルミン分解プロセス2012

    • Author(s)
      相澤優太, 幕田寿典
    • Organizer
      化学工学会第44回秋季大会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Book] マイクロバブル(ファインバブル)のメカニズム 特性制御と実用応用のポイント2015

    • Author(s)
      幕田寿典, 他
    • Total Pages
      469
    • Publisher
      情報機構
    • Related Report
      2014 Annual Research Report
  • [Book] Micro- and Nanobubbles: Fundamentals and Applications2014

    • Author(s)
      Tsuge Hideki, Toshinori Makuta, et al.
    • Total Pages
      355
    • Publisher
      Pan Stanford Publishing
    • Related Report
      2014 Annual Research Report
  • [Book] マイクロ/ナノカプセルの調製、徐放性制御と応用事例2014

    • Author(s)
      幕田寿典, 他
    • Total Pages
      510
    • Publisher
      技術情報協会
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 中空粒子の製造装置および制御手法2014

    • Inventor(s)
      幕田寿典,江黒躍也
    • Industrial Property Rights Holder
      幕田寿典,江黒躍也
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-234062
    • Filing Date
      2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 中空粒子の製造方法および製造装置2013

    • Inventor(s)
      幕田寿典,須藤太一
    • Industrial Property Rights Holder
      幕田寿典,須藤太一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-158353
    • Filing Date
      2013-07-30
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 気泡から作る中空粒子およびその製造装置2013

    • Inventor(s)
      幕田寿典,須藤太一
    • Industrial Property Rights Holder
      幕田寿典,須藤太一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-224806
    • Filing Date
      2013-10-30
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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