| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Outline of Final Research Achievements |
To get a fundamental knowledge on the microbubble drag delivery system using ultrasound-contrast-agent, two kinds of experiments were conducted. One is the surface modification of microbubbles for selective adhesion to the target. The other is manipulation of microbubbles using ultrasound field. In this study, we succeeded to achieve the selective adhesion of microbubbles with the surface modification using biotin molecules, to the avidin-coated solid wall. We further developed the microbubble manipulation system using focused ultrasound and succeeded to manipulate them on arbitrary trajectories in 2-D plane. We also succeeded to trap the microbubble clusters under the presence of flows. These results give us the fundamental knowledge for the future possible applications.
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