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Possibility of the simultaneous measurements of surface charge and density by the scanning haptic microscope

Research Project

Project/Area Number 24360162
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Measurement engineering
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

TAKAMIZAWA KEIICHI  独立行政法人国立循環器病研究センター, 研究所, 研究員 (10163312)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Yasuhide  独立行政法人国立循環器病研究センター, 研究所, 室長 (50250262)
KANDA Keiichi  京都府立医科大学, 医学部, 講師 (60295649)
WATANABE Taiji  京都府立医科大学, 医学部, 助教 (20448723)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords触覚顕微鏡 / 弾性率分布 / 密度分布 / 計測機器 / 電荷分布
Outline of Final Research Achievements

As the development of the new measurement function of SHM following surface morphology and elasticity distribution measurements, this study found the possibility of the density measurement and succeeded in microimaging of the density structure of the aortic wall for the first time in the world. Tip diameter used a glass needle of around 5μm, and SHM measured the second, the third resonance frequency around glass needle to measurement frequency each and realized density imaging of the sample surface without spoiling a surface shape and an observation function of the coefficient of elasticity distribution by demanding the difference of a frequency rate of change provided by the measurement at both frequency. We found that the domain where elastin elastin was rich was high-density by using a canine aortic wall as a sample.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (15 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (8 results)

  • [Journal Article] Biaxial contractile mechanics of common carotid arteries of rabbit2015

    • Author(s)
      Takamizawa K
    • Journal Title

      Journal of Biomechnical Engineering

      Volume: 137

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In-body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014

    • Author(s)
      Nakayama Y, Takewa Y, Sumukura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohnuma K, Kanda K, Tatsumi E
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: (in press) Issue: 1 Pages: 1-10

    • DOI

      10.1002/jbm.b.33186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acceleration of rubust "biotube" vascular graft fabrication by in-body tissue architecture technology using a novel eosin Y-releasing mold2014

    • Author(s)
      Nakayama Y, Tsujinaka T
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: 102B Issue: 2 Pages: 231-238

    • DOI

      10.1002/jbm.b.32999

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-Euclidean Stress-Free Configuration of Arteries Accounting for Curl of Axial Strips Sectioned from Vessels.2013

    • Author(s)
      Takamizawa K, Nakayama Y
    • Journal Title

      J Biomechanical Engineering

      Volume: 135 Issue: 11

    • DOI

      10.1115/1.4025328

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress Distribution in a Bilayer Elastic Model of a Coronary Artery2013

    • Author(s)
      Takamizawa K, Nakayama Y
    • Journal Title

      J Applied Mechanics

      Volume: 16 Issue: 4 Pages: 59-65

    • DOI

      10.1115/1.4007863

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface density mapping of natural tissue by a scanning microscope (SHM)2013

    • Author(s)
      Takeshi Moriwaki
    • Journal Title

      Journal of Medical Engineering & Technology

      Volume: 37 Pages: 96-101

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of local elastic distribution in aortic tissues under static strain condition by use of a scanning haptic microscope2013

    • Author(s)
      Moriwaki T, Oie T, Takamizawa K, Murayama Y, Fukuda T, Omata S, Nakayama Y
    • Journal Title

      J Artif Organs

      Volume: 16 Issue: 1 Pages: 91-97

    • DOI

      10.1007/s10047-012-0674-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体内組織形成術(IBTA)の可能性拡大:線で面を捉える2015

    • Author(s)
      中山泰秀、古越真耶、船山麻理菜、森脇健司
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 3Dプリンターを用いた光造形と生体内組織形成術による体内造形の融合によるバイオバルブ心臓弁の開発2014

    • Author(s)
      中山泰秀
    • Organizer
      第76回日本臨床外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生体内組織形成術による次世代型自家組織心臓弁の開発2014

    • Author(s)
      武輪能明、中山泰秀、岸本 諭、伊達数馬、住倉博仁、神田圭一、田地川 勉、田中孝晴、妙中義之、巽 英介
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 走査型触覚顕微鏡によるバイオシート人工角膜移植時の力学的適合化過程の観察2013

    • Author(s)
      森脇 健司, 滝山 直昭, 水野 壮司, 福田 達, 尾股 定夫, 上地 正実, 中山 泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体内組織形成術により作製したコラーゲン膜(バイオシート)の代用角膜としての検討2013

    • Author(s)
      滝山 直昭, 水野 壮司, 森脇 健司, 上地 正実, 中山 泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 再生医療と人工臓器 心臓修復材としてのバイオシート ラット右室流出路移植モデルでの検討2013

    • Author(s)
      水野 壮司, 山南 将志, 中山 泰秀
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] バイオチューブ人工血管の移植前後での力学的構造変化 走査型触覚顕微鏡(SHM)観察2012

    • Author(s)
      森脇健司
    • Organizer
      第64回日本生物工学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 走査型触覚顕微鏡(SHM)を用いたバイオチューブ人工血管の力学的再生度の評価2012

    • Author(s)
      森脇健司
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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