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Demonstration and extension of Mizunami-Unoki learning model.

Research Project

Project/Area Number 24370030
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionHokkaido University

Principal Investigator

MIZUNAMI Makoto  北海道大学, 理学(系)研究科(研究院), 教授 (30174030)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords学習 / 記憶 / 予測誤差 / ドーパミン / オクトパミン / 昆虫 / 視覚 / 嗅覚 / ブロッキング / 習慣形成 / コオロギ / 古典的条件付け
Outline of Final Research Achievements

I obtained three major results in this study. At first, I demonstrated the validity of the prediction error theory. In associative learning in mammals, it is accepted that the error between actual and predicted reward determines whether learning occurs: This theory stems from the finding of a blocking phenomenon, but blocking can also be accounted for by other theories. I demonstrated blocking in classical conditioning in crickets and obtained evidence to support the prediction error theory. Second, I found evidence of “habit formation”, which make the conditioned response insensitive to devaluation of the US. The results demonstrate, for the first time, habit formation in classical conditioning in any animals. Thirdly, I performed intracellular recordings from many of output neurons of the lobes of the mushroom body in cockroaches. Some of these neurons exhibited changes in their responses to an odor presentation after pairing of the odor with sucrose reward.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (56 results)

All 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (33 results) (of which Invited: 2 results) Book (9 results) Remarks (4 results)

  • [Journal Article] Coarse topographic organization of pheromone-sensitive afferents from different antennal surfaces in the American cockroach.2015

    • Author(s)
      Nishino H, Watanabe H, Kamimura I, Yokohari F, Mizunami M.
    • Journal Title

      Neurosci. Lett.

      Volume: 595 Pages: 35-40

    • DOI

      10.1016/j.neulet.2015.04.006

    • NAID

      120005952006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical evidence for the prediction error theory in associative learning.2015

    • Author(s)
      Terao K, Matsumoto Y, Mizunami M
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 8929-8929

    • DOI

      10.1038/srep08929

    • NAID

      120005602518

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toward elucidating diversity of neural mechanisms underlying insect learning.2015

    • Author(s)
      Mizunami M, Hamanaka Y, Nishino H.
    • Journal Title

      Zool. Lett.

      Volume: 1 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s40851-014-0008-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Roles of calcium/calmodulin-dependent kinase II in long-term memory formation in crickets.2015

    • Author(s)
      Mizunami M, Nemoto Y, Terao K, Hamanaka Y, Matsumoto Y.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 9 Pages: 9-9

    • DOI

      10.1371/journal.pone.0107442

    • NAID

      120005496509

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclic nucleotide–gated channels, calmodulin, adenylyl cyclase and calcium/calmodulin-dependent kinase II are required for late but not early long-term memory formation in the honey bee2014

    • Author(s)
      Matsumoto Y, Sandoz JC, Devaud JM, Lormant F, Mizunami M, Giurfa M
    • Journal Title

      Learning & Memory

      Volume: 21 Issue: 5 Pages: 272-286

    • DOI

      10.1101/lm.032037.113

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of NO signaling in long-term memory formation in visual learning in an insect.2013

    • Author(s)
      Matsumoto Y, Hirashima D, Terao K, Mizunami M.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 7 Pages: e68538-e68538

    • DOI

      10.1371/journal.pone.0068538

    • NAID

      120005342541

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis and modeling of neural processes underlying sensory preconditioning2013

    • Author(s)
      Matsumoto Y, Hirashima D, Mizunami M.
    • Journal Title

      Neurobiol. Learn. Mem.

      Volume: 101 Pages: 103-113

    • DOI

      10.1016/j.nlm.2013.01.008

    • NAID

      120005228719

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Participation of NO signaling in formation of long-term memory in salivary conditioning of the cockroach.2013

    • Author(s)
      Matsumoto, C.S., Kuramochi, T., Matsumoto, Y., Watanabe, H., Nishino, H., Mizunami, M.
    • Journal Title

      Neuroscience Letters

      Volume: 印刷中 Pages: 4-8

    • DOI

      10.1016/j.neulet.2013.01.010

    • NAID

      120005295655

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Divergent and convergent projections to the two parallel olfactory centers from two neighboring, pheromone-receptive glomeruli in the male American cockroach.2012

    • Author(s)
      Nishino H., Iwasaki M., Kamimura I., Mizunami M.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 印刷中 Issue: 15 Pages: 3428-3445

    • DOI

      10.1002/cne.23111

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual and olfactory input segregation in the mushroom body calyces in a basal neopteran, the American cockroach2012

    • Author(s)
      Nishino H, Iwasaki M, Yasuyama K, Hongo H, Watanabe H, Mizunami M.
    • Journal Title

      Arthropod Structure & Development

      Volume: 41 Issue: 1 Pages: 3-16

    • DOI

      10.1016/j.asd.2011.08.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 加齢コオロギにみられる長期記憶障害に対するメラトニンの抑制効果2014

    • Author(s)
      松本幸久、松本千尋、水波誠、中野真樹、服部淳彦
    • Organizer
      日本動物学会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] ワモンゴキブリにおけるドーパミン免疫陽性ニューロンの脳内分布2014

    • Author(s)
      浜中良隆、水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 予測誤差に基づく昆虫の学習2014

    • Author(s)
      寺尾勘太、松本幸久、水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 昆虫の学習は予測誤差に基づくのか?2014

    • Author(s)
      水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] コオロギの他個体観察による学習2014

    • Author(s)
      蝦名宥輝、水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      東北大学(仙台市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Observational learning in crickets.2014

    • Author(s)
      Ebina H, Mizunami M
    • Organizer
      2014 ICN/JSCPB
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Extavour C. oskar functions in adult neural stem cells to influence long-term memory formation in the cricket Gryllus bimaculatus.2014

    • Author(s)
      Ewen-Campen B, Wakuda R, Terao K, Matsumoto Y, Mizunami M,
    • Organizer
      2014 ICN/JSCPB
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dopaminergic neurons in the brain of the cockroach, Periplaneta americana.2014

    • Author(s)
      Hamanaka Y, Mizunami M.
    • Organizer
      2014 ICN/JSCPB
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Conditioning parameters for long-term memory formation in the cockroach.2014

    • Author(s)
      Hosono S, Mizunami M.
    • Organizer
      2014 ICN/JSCPB
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Critical evidence for the prediction error theory in associative learning.2014

    • Author(s)
      Terao K, Matsumoto Y., Mizunami M
    • Organizer
      2014 ICN/JSCPB
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sensing the structural architecture of odor plumes with a single antenna2014

    • Author(s)
      Nishino H, Iwasaki M, Yoritsune A, Kamimura I,Mizunami M
    • Organizer
      2014 ICN/JSCPB
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Roles of aminergic neurons in insect learning.2014

    • Author(s)
      Mizunami M
    • Organizer
      Hokkaido Neuroethology workshops
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-07-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dopaminergic neurons in the brain of the cockroach, Periplaneta americana.2014

    • Author(s)
      Hamanaka Y, Mizunami M.
    • Organizer
      Hokkaido Neuroethology workshops
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Observational learning in crickets.2014

    • Author(s)
      Ebina H, Mizunami M.
    • Organizer
      Hokkaido Neuroethology workshops
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Critical evidence for the prediction error theory in associative learning.2014

    • Author(s)
      Terao K, Matsumoto Y, Mizunami M.
    • Organizer
      Hokkaido Neuroethology workshops
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 昆虫の加齢性記憶障害に対する一酸化窒素とメラトニンの回復効果2014

    • Author(s)
      松本幸久、松本 -佐藤千尋、水波誠、中野真樹、服部淳彦
    • Organizer
      日本抗加齢医学会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2014-06-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Memory molecules in insects : from behavioral pharmacological studios of olfactory learning in crickets.2012

    • Author(s)
      Matsumoto Y, Matsumoto C, Mizunami M.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋コンベンションセンター(名古屋)(招待講演)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] コオロギ古典的条件付けにおける習慣形成の行動学的証明2012

    • Author(s)
      廣鰭翔、松本幸久、水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] フタホシコオロギの嗅覚学習におけるPKCシグナルの役割解析2012

    • Author(s)
      川中子沙織、松本幸久、水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] コオロギ古典的条件付けにおける習慣形成2012

    • Author(s)
      廣鰭翔、松本幸久、水波誠
    • Organizer
      日本動物学会北海道支部会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-08-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis and modeling of sensory preconditioning in crickets.2012

    • Author(s)
      Mizunami M, Matsumoto Y, Hirashima D.
    • Organizer
      10th International Congress of Neuroethology
    • Place of Presentation
      Maryland (USA)
    • Year and Date
      2012-07-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Olfactory conditioning of mandible elevation response in cricket.2012

    • Author(s)
      Matsumoto Y, Matsumoto C, Mizunami M.
    • Organizer
      日本比較生理生化学会
    • Place of Presentation
      総合研究大学院大学(葉山市)
    • Year and Date
      2012-07-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Roles of aminergic neurons in memory acquisition and retrieval in crickets.2012

    • Author(s)
      Mizunami M.
    • Organizer
      International Symposium : Biogenic Amines in Insects
    • Place of Presentation
      Frie Univ. Berlin (Germany)(Invited lecture)
    • Year and Date
      2012-07-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis and modeling of sensory preconditioning in crickets

    • Author(s)
      Mizunami M, Matsumoto Y, Hirashima D
    • Organizer
      日本比較生理生化学会
    • Place of Presentation
      イーグレひめじ(姫路市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] コオロギにおけるブロッキング現象の確認

    • Author(s)
      寺尾勘太,松本幸久,水波誠
    • Organizer
      日本動物学会北海道支部会
    • Place of Presentation
      北海道教育大学(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゴキブリを用いた新しい学習実験系の確立

    • Author(s)
      細野翔平,松本幸久,水波誠
    • Organizer
      日本動物学会北海道支部会
    • Place of Presentation
      北海道教育大学(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNAi によるコオロギの記憶形成に関わる分子機構の解明

    • Author(s)
      和久田亮,松本幸久,水波誠
    • Organizer
      日本動物学会北海道支部会
    • Place of Presentation
      北海道教育大学(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] コオロギの古典的条件づけにおけるブロッキング

    • Author(s)
      寺尾勘太,松本幸久、水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山大学(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] コオロギ古典的条件付けにおける習慣形成とオクトパミンニューロンの関係の解明

    • Author(s)
      廣鰭翔,松本幸久,水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山大学(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNA 干渉法によるコオロギの学習・記憶の分子メカニズムの解析

    • Author(s)
      和久田亮,中村太郎,松本幸久,野地澄晴,三戸太郎,水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山大学(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] フタホシコオロギの加齢性記憶障害における飼育環境の影響

    • Author(s)
      松本幸久,松本-佐藤千尋,中野真樹,服部淳彦,水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山大学(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] MER を用いたゴキブリの学習

    • Author(s)
      細野翔平,松本幸久,水波誠
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山大学(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intelligence with microbrains: Cognitive processes underlying insect learning

    • Author(s)
      Mizunami M
    • Organizer
      International workshop on animal instinctive and intelligent behaviors
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Book] 動物の事典2015

    • Author(s)
      水波誠
    • Publisher
      朝倉書店
    • Related Report
      2014 Annual Research Report
  • [Book] Bioinspired Actuators and Sensors2015

    • Author(s)
      Taya M, Vonkenburgh Ev, Mizunami M, Nomura S.
    • Publisher
      Cambridge Univ Press
    • Related Report
      2014 Annual Research Report
  • [Book] 研究者が教える動物実験、第2巻2015

    • Author(s)
      水波誠
    • Publisher
      共立出版
    • Related Report
      2014 Annual Research Report
  • [Book] 研究者が教える動物実験 第3巻2015

    • Author(s)
      松本幸久、水波誠、松本千尋
    • Publisher
      共立出版
    • Related Report
      2014 Annual Research Report
  • [Book] Cricket as a Model Organism: Development, Regeneration, and Behavior2015

    • Author(s)
      Mizunami M
    • Publisher
      Springer-verlag
    • Related Report
      2014 Annual Research Report
  • [Book] 行動生物学辞典2013

    • Author(s)
      水波誠
    • Total Pages
      637
    • Publisher
      東京化学同人
    • Related Report
      2013 Annual Research Report
  • [Book] Invertebrate Learning and Memory2013

    • Author(s)
      Mizunami M., Matsumoto Y., Watanabe H., Nishino H.
    • Total Pages
      12
    • Publisher
      Springer-Verlag
    • Related Report
      2012 Annual Research Report
  • [Book] 高校生物教師用指導書(DVD版)2013

    • Author(s)
      水波誠
    • Total Pages
      5
    • Publisher
      東京書籍
    • Related Report
      2012 Annual Research Report
  • [Book] 研究者が教える動物飼育第2巻「昆虫とクモの仲間」2012

    • Author(s)
      松本幸久、水波誠
    • Total Pages
      4
    • Publisher
      共立出版
    • Related Report
      2012 Annual Research Report
  • [Remarks] 水波誠研究室

    • URL

      https://www.sci.hokudai.ac.jp/~mizunami/MICROB~2/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 水波誠研究室

    • URL

      https://www.sci.hokudai.ac.jp/~mizunami/MICROB~2/

    • Related Report
      2013 Annual Research Report
  • [Remarks] ようこそ水波研究室へ

    • URL

      http://www._sci._hokudai._ac._jp/._mizunami/MICROB._2/index._html

    • Related Report
      2012 Annual Research Report
  • [Remarks] Invertebrate Brain Gallery

    • URL

      http://invbrain._neuroinf.jp/modules/newdb1/list._php?id=2&n=20&sort=1&sort_method=desc&item=0&ml_lang=en

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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