Regulatory system of chromosomal stability by molecules including a novel molecule, CAMP
| Project/Area Number |
24370078
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
TANAKA Kozo 東北大学, 加齢医学研究所, 教授 (00304452)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Go 東北大学, 加齢医学研究所, 助教 (60607563)
HIROTA Toru 公益財団法人がん研究会, がん研究所, 部長 (50421368)
YASUI Akira 東北大学, 加齢医学研究所, 教授 (60191110)
KANNO Shin-ichiro 東北大学, 加齢医学研究所, 講師 (10400417)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 癌 / 細胞・組織 / 染色体 / 細胞分裂 / 染色体分配 / キネトコア / 紡錘体 / 微小管 / 染色体不安定性 |
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| Outline of Final Research Achievements |
We addressed the regulatory mechanism of chromosomal stability, and following findings were obtained. 1) A novel molecule CAMP functions as a complex with HP1, REV7, and POGZ. CAMP knockout mice die soon after birth. 2) A nuclear pore complex component Nup188 recruits NuMA to spindle poles for chromosome segregation. 3) A microtubule associated factor CLIP-170 regulates chromosome segregation through the mechanisms such as Plk1 recruitment to kinetochores. 4) Two motor molecules, Kid and CENP-E, function for chromosome alignment on the spindle.
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Report
(4 results)
Research Products
(38 results)
