| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
In the mouse olfactory system, olfactory sensory neurons (OSNs) expressing the same olfactory receptor (OR) converge their axons to a specific set of glomeruli in the olfactory bulb. It has been demonstrated that ORs control transcriptional levels of axon guidance and sorting molecules to regulate axonal projection of OSNs. However, it remains unknown what is the signaling source for activating ORs. In the present study, we found that ligand-independent basal activities induced by expressed ORs play important roles in the targeting of OSN axons. This finding provides compelling evidence that the basal activity, which had been considered to be noise, is physiologically-important.
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