|Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|Outline of Final Research Achievements
In this study, detailed mechanisms for the recognition and anti-inflammation of immunobiotics in the gut was analyzed by using livestock intestinal epithelial and dendritic cells. As a result, high recognition for immunobiotics by porcine dendritic cells was observed and a common intracellular regulator induced by immunobiotics was found in porcine intestinal epitheliocytes. Furthermore, anti-inflammatory ability of immunobiotics could be verified in vivo study. This study contributes to progress an understanding the molecular regulation of inflammatory cell intranet by immunobiotics.