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Studies on neuropathogenesis of equine herpesviruses

Research Project

Project/Area Number 24380165
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied veterinary science
Research InstitutionGifu University

Principal Investigator

FUKUSHI Hideto  岐阜大学, 応用生物科学部, 教授 (10156763)

Co-Investigator(Kenkyū-buntansha) OHYA Kenji  岐阜大学, 応用生物科学部, 准教授 (50402219)
Co-Investigator(Renkei-kenkyūsha) MATSUMURA Tomio  日本中央競馬会競走馬総合研究所, 栃木支所, 室長 (20446511)
TSUJIMURA Koji  日本中央競馬会競走馬総合研究所, 栃木支所, 室員 (50446514)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywordsウマヘルペスウイルス1型 / 神経病原性 / 網羅的転写解析 / ヘルペスウイルス / 転写解析
Outline of Final Research Achievements

The purpose of this study was to reveal the mechanism of neuropathogenicity of equine herpesvirus type 1 (EHV-1) at the molecular level. Comparing EHV-1 genomes of neuropathogenic and nonneuropathogenic strains, several open reading frames and amino acid substitution including ORF30 D752 neuropathogenic marker were identified. Particularly comparison of neuropathogenic strains possessing ORF30 N752 instead of D752 indicated several viral genes associated with neuropathogenicity of EHV-1. Transcription start site analyses on EHV-1 infected cells showed transcription from whole genome sequence at 8 hour post infection. These results indicated that virus transcription might be much complicated.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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