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Analysis of the genes expressed in canine lymphoma using in vitro and in vivo methodology.

Research Project

Project/Area Number 24380170
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Clinical veterinary science
Research InstitutionYamaguchi University

Principal Investigator

TAKUYA Mizuno  山口大学, 獣医学部, 教授 (90398826)

Co-Investigator(Kenkyū-buntansha) TSUJIMOTO Hajime  東京大学, 大学院農学生命科学研究科, 教授 (60163804)
SHIMIZU Kanako  統合生命医科学研究センター, 上級研究員 (20391980)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsリンパ腫 / 犬
Outline of Final Research Achievements

The genes specifically expressed in canine lymphoma was analyzed in vitro and in vivo. Especially, three genes were analyzed in detail, and the function was elucidated among some of them. This results would expect that these molecules could be target for lymphoma therapy in the future.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (13 results)

  • [Journal Article] Oncolytic effects of reovirus in canine solid tumor cell lines.2015

    • Author(s)
      Igase M, Hwang CC, Coffey M, Okuda M, Noguchi S, Mizuno T.
    • Journal Title

      J Vet Med Sci. 2015 Jan16[Epub ahead of print]

      Volume: 印刷中

    • NAID

      130005071879

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the cytotoxic effect of flavopiridol in canine lymphoma cell lines.2015

    • Author(s)
      Ema Y, Igase M, Takeda Y, Yanase T, Umeki S, Hiraoka H, Okuda M, Mizuno T.
    • Journal Title

      Vet Comp Oncol.

      Volume: 印刷中 Issue: S1 Pages: 95-106

    • DOI

      10.1111/vco.12130

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of oncolytic reovirus in canine lymphoma cell lines.2015

    • Author(s)
      Hwang CC, Umeki S, Igase M, Coffey M, Noguchi S, Okuda M, Mizuno T.
    • Journal Title

      Vet Comp Oncol.

      Volume: 印刷中 Issue: S1 Pages: 61-73

    • DOI

      10.1111/vco.12124

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of microRNA-203 function in CREB/MITF/RAB27a pathway: comparison between canine and human melanoma cells.2015

    • Author(s)
      Noguchi S, Kumazaki M, Mori T, Baba K, Okuda M, Mizuno T, Akao Y.
    • Journal Title

      Vet Comp Oncol.

      Volume: 印刷中 Issue: 4 Pages: 384-394

    • DOI

      10.1111/vco.12118

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the development of asthmatic inflammation by in situ CD4(+)Foxp3 (+) T cells in a mouse model of late allergic asthma.2014

    • Author(s)
      Nakashima T, Hayashi T, Mizuno T.
    • Journal Title

      Inflammation

      Volume: 37(5) Issue: 5 Pages: 1642-1653

    • DOI

      10.1007/s10753-014-9892-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seroepidemiology of Reovirus in Healthy Dogs in Six Prefectures in Japan.2014

    • Author(s)
      Hwang CC, Mochizuki M, Maeda K, Okuda M, Mizuno T.
    • Journal Title

      J Vet Med Sci.

      Volume: 76 (3) Pages: 471-475

    • NAID

      130003382393

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncolytic reovirus in canine mast cell tumor.2013

    • Author(s)
      Hwang CC, Umeki S, Kubo M, Hayashi T, Shimoda H, Mochizuki M, Maeda K, Baba K, Hiraoka H, Coffey M, Okuda M, Mizuno T.
    • Journal Title

      PLoS ONE

      Volume: 8(9)

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-adhesive property of P-selectin glycoprotein ligand-1 (PSGL-1)due to steric hindrance effect.2013

    • Author(s)
      Umeki S, Suzuki R, Ema Y, Shimojima N, Nishinura Y, Okuda M, Mizuno T.
    • Journal Title

      J Cell Biochem.

      Volume: 114 (6) Issue: 6 Pages: 1271-1285

    • DOI

      10.1002/jcb.24468

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model2013

    • Author(s)
      Umeki, S., Ema, Y., Suzuki, R., Kubo, M., Hayashi, T., Okamura, Y., Yamazaki, J., Tsujimoto, H., Tani, K., Hiraoka, H., Okuda, M. and Mizuno, T
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 75 Issue: 4 Pages: 467-474

    • DOI

      10.1292/jvms.12-0448

    • NAID

      130002502194

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 犬乳腺腫瘍細胞株に対する腫瘍溶解性ウイルス療法と化学療法の併用による相乗効果の検討2014

    • Author(s)
      伊賀瀬雅也、Hwang Chung Chew、上林聡之、下川孝子、馬場健司、奥田優、野口俊助、水野拓也
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] イヌのPD-1およびPD-L1に対するモノクローナル抗体の作製とその機能の解析2014

    • Author(s)
      正司麗葉、伊賀瀬雅也、下川孝子、馬場健司、奥田優、野口俊助、水野拓也
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reovirus induces poptotic cell death by the dysregulation of the Ras signling pathway2014

    • Author(s)
      Hwang Chung Chew、伊賀瀬雅也、下川孝子、馬場健司、奥田優、野口俊助、水野拓也
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reovirus infection dysregulates the Ras signaling pathway in canine mast cell tumor cells2014

    • Author(s)
      Hwang CC, Coffery M, Noguchi S, Okuda M, Mizuno T.
    • Organizer
      23rd Biennial Congress of the EUROPEAN ASSOCIATION FOR CANCER RESEARCH
    • Place of Presentation
      Munich(ドイツ)
    • Year and Date
      2014-07-05 – 2014-07-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腫瘍溶解性ウイルスによる犬乳腺腫瘍細胞に対する抗腫瘍効果の検討2014

    • Author(s)
      伊賀瀬雅也、Chung Chew Hwang、久保正仁、中嶋朋美、林俊春、馬場健司、野口俊助、奥田優、水野拓也
    • Organizer
      日本獣医内科学アカデミー第10回記念学術大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 日本国内の主要犬種における犬白血球抗原I型の遺伝子解析2013

    • Author(s)
      中谷亮太、井上公美、川野浩志、奥田優、水野拓也
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] レオウイルスによる犬の各種腫瘍細胞株に対する細胞死の誘導2013

    • Author(s)
      伊賀瀬雅也、Chung Chew Hwang、奥田優、水野拓也
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Reovirus effectively induces oncolysis in canine mast cell tumor in vivo and ex vivo2013

    • Author(s)
      Chung Chew Hwang、梅城沙織、伊賀瀬雅也、久保正仁、林俊春、奥田優、水野拓也
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] イヌインターフェロンガンマによる犬腫瘍細胞株の増殖抑制効果の検討2013

    • Author(s)
      濱村友紀、奥田優、水野拓也
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学(岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] イヌのリンパ腫において過剰発現する遺伝子の解析2012

    • Author(s)
      柳瀬拓磨、梅城沙織、酒井治、平岡博子、藤原亜紀、辻本元、奥田優、水野拓也
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(盛岡市)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] イヌのTT-1に対する抗体の特異性の解析2012

    • Author(s)
      酒井治、中谷亮太、梅城沙織、酒井洋樹、久保正仁、森本将弘、林俊春、平岡博子、奥田優、水野拓
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(盛岡市)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新しく樹立したイヌリンパ腫細胞株のin vitroおよびin vivoにおける性状解析2012

    • Author(s)
      梅城沙織、江馬康夫、鈴木綾一、久保正仁, 林俊春、岡村泰彦、山崎淳平、辻本元、谷健二、平岡博子、奥田優、水野拓也
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(盛岡市)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Discovering the oncolytic potential of reovirus in veterinary medicine : reovi rus-induced cell death in canine lymphoma and last cell tumor ceell lines2012

    • Author(s)
      Hwang Chung Chew、梅城沙織、中川貴之、下田宙、望月雅美、前田健、平岡博子、奥田優、水野拓也
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(盛岡市)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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