Insulin-containing nanocapsules: an approach to artificial pacreas
| Project/Area Number |
24390006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
ANZAI Jun-ichi 東北大学, 薬学研究科(研究院), 教授 (40159520)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATO Katsuhiko 東北大学, 大学院薬学研究科, 助教 (80400266)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
EGAWA Yuya 城西大学, 薬学部, 准教授 (90400267)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Keywords | 交互累積膜 / ナノカプセル / ミクロカプセル / インスリン |
|---|
| Outline of Final Research Achievements |
Phenylboronic acid-modified polymers and insulin-containing carcium carbonate particles (spherical particles of 5-10 nm in diameter) were prepared. The release of insulin from the particles could be regulated by coating layer-by-layer films on the particles. Phenylboronic acid-modified poly(allylamine) and dendrimers were found to be useful for constructing insulin-delivery systems. It was also found that layer-by-layer films combined with enzyme can be disintegrated in the presence of glucose. The results show that phenylboronic acid-modified thin film are useful materials for developing insulin delivery systems.
|
Report
(4 results)
Research Products
(17 results)
