Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenvironment.
| Project/Area Number |
24390010
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIDA Tatsuhiro 徳島大学, ヘルスバイオサイエンス研究部, 教授 (50325271)
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| Co-Investigator(Kenkyū-buntansha) |
際田 弘志 徳島大学, ヘルスバイオサイエンス研究部, 非常勤講師 (50120184)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | ドラッグデリバリー / リポソーム / がん治療 / がん微小環境 |
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| Outline of Final Research Achievements |
Efficient systemic delivery of anticancer drug to tumor tissue is a current critical challenge. Several studies have demonstrated that nanoparticles enhance the systemic delivery of anticancer drug to tumor via EPR effect. However, the disordered tumor microenvironment still poses a potential impediment with respect to the efficient delivery. Metronomic chemotherapy successfully improved the accumulation of PEG-coated liposome in solid tumor and improved therapeutic efficacy of oxaliplatin (l-OHP) encapsulated in the liposome. We also showed that repeated injection of l-OHP containing PEGylated liposome enhanced the accumulation of subsequently injected liposome and improved their therapeutic effect compared to the treatment with longer intervals between doses. The methodology (regimen) we proposed in this study may be applicable for clinical setting.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome.2014
Author(s)
Nakamura, H., Doi, Y., Abu Lila, A.S., Nagao, A., Ishida, T., Kiwada, H
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Journal Title
Eur. J. Pharm. Biopharm.
Volume: 87
Issue: 1
Pages: 142-151
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin.2014
Author(s)
Suzuki, T., Ichihara, M., Hyodo, K., Yamamoto, E., Ishida, T., Kiwada, H., Kikuchi, H., Ishihara, H.
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Journal Title
Int. J. Pharm
Volume: 476
Issue: 1-2
Pages: 205-212
DOI
Related Report
Peer Reviewed
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