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Analysis of novel cGMP pathway regulating innate immune responses

Research Project

Project/Area Number 24390014
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionTohoku University

Principal Investigator

KURATA Shoichiro  東北大学, 薬学研究科(研究院), 教授 (90221944)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords自然免疫 / cGMP / ショウジョウバエ
Outline of Final Research Achievements

A receptor-type guanylate cyclase, Gyc76C, is a novel receptor regulating innate immune responses. Gyc76C regulates the activation of humoral responses in cGMP-dependent manner, and the activation of cellular responses in cGMP-independent manner. This study identified several Gyc76C down-stream factors involving the Gyc76C-mediated activation of humoral responses, and the Gyc76C-mediated activation of cellular responses.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 5 results) Remarks (2 results)

  • [Journal Article] ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor2014

    • Author(s)
      Tomita T, Ieguchi K, Coin F, Kato Y, Kikuchi H, Oshima Y, Kurata S, Maru Y
    • Journal Title

      PLoS One

      Volume: 30 Issue: 9 Pages: e108957-e108957

    • DOI

      10.1371/journal.pone.0108957

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peptidoglycan recognition proteins in Drosophila immunity2014

    • Author(s)
      Kurata, S.:
    • Journal Title

      Dev. Comp. Immunol.

      Volume: 42 Issue: 1 Pages: 36-41

    • DOI

      10.1016/j.dci.2013.06.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic Antenna Induction by Overexpression of <i>CG17836/Xrp1</i> Encoding an AT-Hook DNA Binding Motif Protein in <i>Drosophila</i>2013

    • Author(s)
      Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Tomonori Katsuyama, Tatsurou Minami, Hirofumi Furuhashi, Yoshiteru Oshima, and Shoichiro Kurata
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 2 Pages: 339-344

    • DOI

      10.1271/bbb.120756

    • NAID

      10031164738

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terresterol, a Polyoxygenated Lanostanoid, Isolated from the Oomycete Saprolegnia terrestris, and Its Innate Immune-Promoting Activity2013

    • Author(s)
      Kikuchi, H., Sato, Y., Kurata, S., Katou, Y., Oshima, Y.
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 17 Pages: 3536-3542

    • DOI

      10.1016/j.tet.2013.02.088

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host-microbe interactions in the gut of Drosophila melanogaster2013

    • Author(s)
      Kuraishi, T., Hori, A., Kurata, S.
    • Journal Title

      Frot. Physiol.

      Volume: 4 Pages: 375-375

    • DOI

      10.3389/fphys.2013.00375

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress2012

    • Author(s)
      Tsuzuki, S., Ochiai, M., Matsumoto, H., Kurata, S., Ohnishi A., Hayakawa, Y.
    • Journal Title

      Sci. Rep.

      Volume: 2 Issue: 1 Pages: 210-210

    • DOI

      10.1038/srep00210

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Dimeric and Monomeric Chromanones, Gonytolides D-G, Isolated from the Fungus Gonytrichum sp2012

    • Author(s)
      Kikuchi, H., Isobe, M., Kurata, S., Katou, Y., Oshima, Y.
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 31 Pages: 6218-6223

    • DOI

      10.1016/j.tet.2012.05.064

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Novel Regulator, Sherpa, Regulating Drosophila NF-kB Signaling2015

    • Author(s)
      Kurata, S.
    • Organizer
      The 3rd Homeostatic Inflammation International Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-01-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity2014

    • Author(s)
      Kurata, S.
    • Organizer
      Glasgow Epitheliome meeting in 2014
    • Place of Presentation
      Glasgow UK
    • Year and Date
      2014-04-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Recognition of microbes and regulation of innate immunity2014

    • Author(s)
      Shoichiro Kurata
    • Organizer
      KVA-JSPS Seminar
    • Place of Presentation
      Sweden: Uppsala, Umea, Stockholm, and Finland: Tampere
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity2014

    • Author(s)
      Shoichiro Kurata
    • Organizer
      Asian invertebrate immunity symposium 2013
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A receptor-type guanylate cyclase mediates humoral and cellular responses in Drosophila immunity2013

    • Author(s)
      Shoichiro Kurata
    • Organizer
      EMBO-ESF Research Conference “Integrated Insect Immunology: From Basic Biology To Environmental Applications”
    • Place of Presentation
      Pultusk, Poland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity2012

    • Author(s)
      Shoichiro Kurata
    • Organizer
      XXIV International Congress of Entomology
    • Place of Presentation
      Daegu, Korea(招待講演)
    • Year and Date
      2012-08-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] New Toll gate for humoral and cellular immune response in Drosophila2012

    • Author(s)
      Shoichiro Kurata
    • Organizer
      The 12th Congress of the International Society of Developmental and Comparative Immunology
    • Place of Presentation
      Fukuoka, Japan(招待講演)
    • Year and Date
      2012-07-09
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東北大学大学院薬学研究科生命機能解析学分野

    • URL

      http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 生命機能解析学分野

    • URL

      http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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