Analysis of novel cGMP pathway regulating innate immune responses

• Project/Area Number: 24390014
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: KURATA Shoichiro 東北大学, 薬学研究科(研究院), 教授 (90221944)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: 自然免疫 / cGMP / ショウジョウバエ

Outline of Final Research Achievements

A receptor-type guanylate cyclase, Gyc76C, is a novel receptor regulating innate immune responses. Gyc76C regulates the activation of humoral responses in cGMP-dependent manner, and the activation of cellular responses in cGMP-independent manner. This study identified several Gyc76C down-stream factors involving the Gyc76C-mediated activation of humoral responses, and the Gyc76C-mediated activation of cellular responses.

Research Products

• [Journal Article] ZFC3H1, a zinc finger protein, modulates IL-8 transcription by binding with Celastramycin A, a potential immune suppressor. (2014)
  • Author(s): Tomita T, Ieguchi K, Coin F, Kato Y, Kikuchi H, Oshima Y, Kurata S, Maru Y
  • Journal Title: PLOS ONE Volume: 30
  • DOI: 10.1371/journal.pone.0108957
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Peptidoglycan recognition proteins in Drosophila immunity (2014)
  • Author(s): Kurata, S.:
  • Journal Title: Dev. Comp. Immunol. Volume: 42 Pages: 36-41
  • DOI: 10.1016/j.dci.2013.06.006
  • Peer Reviewed
• [Journal Article] Ectopic Antenna Induction by Overexpression of <i>CG17836/Xrp1</i> Encoding an AT-Hook DNA Binding Motif Protein in <i>Drosophila</i> (2013)
  • Author(s): Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Tomonori Katsuyama, Tatsurou Minami, Hirofumi Furuhashi, Yoshiteru Oshima, and Shoichiro Kurata
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: 77 Issue: 2 Pages: 339-344
  • DOI: 10.1271/bbb.120756
  • NAID: 10031164738
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Terresterol, a Polyoxygenated Lanostanoid, Isolated from the Oomycete Saprolegnia terrestris, and Its Innate Immune-Promoting Activity (2013)
  • Author(s): Kikuchi, H., Sato, Y., Kurata, S., Katou, Y., Oshima, Y.
  • Journal Title: Tetrahedron Volume: 69 Pages: 3536-3542
  • DOI: 10.1016/j.tet.2013.02.088
  • Peer Reviewed
• [Journal Article] Host-microbe interactions in the gut of Drosophila melanogaster (2013)
  • Author(s): Kuraishi, T., Hori, A., Kurata, S.
  • Journal Title: Frontiers in Physiology Volume: 4 Pages: 375-375
  • DOI: 10.3389/fphys.2013.00375
  • Peer Reviewed
• [Journal Article] Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress. (2012)
  • Author(s): Tsuzuki, S., Ochiai, M., Matsumoto, H., Kurata, S., Ohnishi A., Hayakawa, Y.
  • Journal Title: Sci. Rep Volume: 2 Pages: 210-210
  • DOI: 10.1038/srep00210
  • Peer Reviewed
• [Journal Article] New Dimeric and Monomeric Chromanones, Gonytolides D-G, Isolated from the Fungus Gonytrichum sp. (2012)
  • Author(s): Kikuchi, H., Isobe, M., Kurata, S., Katou, Y., Oshima, Y.
  • Journal Title: Tetrahedron Volume: 68 Pages: 6218-6223
  • DOI: 10.1016/j.tet.2012.05.064
  • Peer Reviewed
• [Presentation] Novel Regulator, Sherpa, Regulating Drosophila NF-kB Signaling (2015)
  • Author(s): Kurata, S.
  • Organizer: The 3rd Homeostatic Inflammation International Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2015-01-29
  • Invited
• [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity (2014)
  • Author(s): Kurata, S.
  • Organizer: Glasgow Epitheliome meeting in 2014
  • Place of Presentation: Glasgow UK
  • Year and Date: 2014-04-23
  • Invited
• [Presentation] Recognition of microbes and regulation of innate immunity (2014)
  • Author(s): Shoichiro Kurata
  • Organizer: KVA-JSPS Seminar
  • Place of Presentation: Sweden: Uppsala, Umea, Stockholm, and Finland: Tampere
  • Invited
• [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity (2014)
  • Author(s): Shoichiro Kurata
  • Organizer: Asian invertebrate immunity symposium 2013
  • Place of Presentation: Busan, Korea
  • Invited
• [Presentation] A receptor-type guanylate cyclase mediates humoral and cellular responses in Drosophila immunity (2013)
  • Author(s): Shoichiro Kurata
  • Organizer: EMBO-ESF Research Conference “Integrated Insect Immunology: From Basic Biology To Environmental Applications”
  • Place of Presentation: Pultusk, Poland
  • Invited
• [Presentation] A link coordinating humoral and cellular responses in Drosophila immunity (2012)
  • Author(s): Shoichiro Kurata
  • Organizer: XXIV International Congress of Entomology
  • Place of Presentation: Daegu, Korea(招待講演)
  • Year and Date: 2012-08-20
• [Presentation] New Toll gate for humoral and cellular immune response in Drosophila (2012)
  • Author(s): Shoichiro Kurata
  • Organizer: The 12th Congress of the International Society of Developmental and Comparative Immunology
  • Place of Presentation: Fukuoka, Japan(招待講演)
  • Year and Date: 2012-07-09
• [Remarks] 東北大学大学院薬学研究科生命機能解析学分野
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html
• [Remarks] 生命機能解析学分野
  • URL: http://www.pharm.tohoku.ac.jp/~seimei/seimei_original.html