|Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
|Outline of Final Research Achievements
Vascular endothelial cells are the only cell type that directly contact with blood. It was reported that organ toxicity of cadmium possibly depends on the toxicity of the metal to vascular endothelial cells; however, the mechanisms have been unclear. In the present study, we found that TGF-β, an inflammatory cytokine that can influence the cytotoxicity of cadmium to vascular endothelial cells, induces the expression of a zinc transporter ZIP8 in vascular endothelial cells. In addition, it was revealed that the expression level of ZIP8 as well as metallothionein induction is important for interaction of zinc with cadmium in the cells.