• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of support system for dosage adjustment to avoid drug-drug interactions caused by fluoropyrimidine anti-cancer drugs

Research Project

Project/Area Number 24390038
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

SAWADA Yasufumi  東京大学, 大学院薬学系研究科, 教授 (80114502)

Co-Investigator(Kenkyū-buntansha) HORI Satoko  東京大学, 大学院情報学環, 准教授 (70313145)
SATOH Hiroki  東京大学, 大学院薬学系研究科, 助教 (80451855)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords薬物間相互作用 / フッ化ピリミジン系抗癌薬 / 薬物代謝酵素 / フェニトイン / ワルファリン / 薬物相互作用
Outline of Final Research Achievements

Fluoropyrimidine anti-cancer drugs cause the drug-drug interactions with anti-epileptic drugs (phenytoin) and anticoagulants (warfarin). In this study, we conducted experiment using HepaRG cells, and then elucidated the mechanism of this interaction. Also, we collected cases which were co-administrated fluoropyrimidine anti-cancer drugs and phenytoin or warfarin, and constructed pharmacokinetic-pharmacodynamic model that can represent the interaction. When used in combination with fluoropyrimidine anti-cancer drugs, it is possible to predict a phenytoin dosage as not to vary the phenytoin concentration using the constructed models.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (2 results)

All 2013 2012

All Presentation (2 results)

  • [Presentation] 薬物動態解析システムを搭載したフェニトイン・ティーエスワン間相互作用回避支援アプリの開発2013

    • Author(s)
      新保 拓未, 佐藤 宏樹, 三木 晶子, 堀 里子, 澤田 康文.
    • Organizer
      第23回日本医療薬学会年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] フェニトインとTS-1との相互作用回避のための薬物動態モデル2012

    • Author(s)
      新保拓未
    • Organizer
      第22回日本医療薬学会年会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi