Neural mechanisms underlying the circadian pacemakers
| Project/Area Number |
24390052
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI TAKESHI 金沢大学, 医学系, 教授 (60251055)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 概日リズム / 視交叉上核 / バソプレシン / 遺伝子操作マウス / 体内時計 / 神経ネットワーク / 時計遺伝子 / トランスジェニックマウス / Bmal1 / VIP / casein kinase 1d / Vgat / SCN / AVP / 食餌 |
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| Outline of Final Research Achievements |
The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. However, the neural mechanisms underlying the generation of robust and stable circadian oscillation by the SCN network remains unknown. We generated mice with neuron type-specific genetic manipulations and performed analyses of their behavior, gene expression in vivo and ex vivo, and so on. We found that AVP producing neurons in the SCN play a critical role in the generation of stable circadian behavioral rhythms and the determination of the circadian period.
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Report
(5 results)
Research Products
(37 results)
