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Neurotransmitters in the defense response

Research Project

Project/Area Number 24390057
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKagoshima University

Principal Investigator

KUWAKI Tomoyuki  鹿児島大学, 医歯(薬)学総合研究科, 教授 (80205260)

Co-Investigator(Renkei-kenkyūsha) OOTSUKA Youichirou  鹿児島大学, 大学院医歯学総合研究科, 客員研究員 (70302403)
Research Collaborator KASHIWADANI Hideki  
KUSUMOTO Ikue  
ZHANG Wei  
MIYATA Kohei  
MATSUMOTO Ami  
IKOMA Yoko  
KONO Yu  
SAMESHIMA Kohei  
KUBO Rintaro  
KAWATAKI Masanori  
USHIKAI Jumpei  
IWAMOTO Yoshiyuki  
SAKO Haruka  
ISHIKAWA Sodemi  
SUNANAGA Jinko  
TAKAHASHI Yoshiko  
KUROKI Chiharu  
YAMAGUCHI Keiji  
FUTATSUKI Takahiro  
TASHIRO Shogo  
KANMURA Yuichi  
YAMAGUCHI Ran  
NAGATA Keiichiro  
KAJIYA Katsuko  
SAKURAI Takeshi  
YAMANAKA Akihiro  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords防衛反応 / オレキシン / 小胞体グルタミン酸輸送体-2 / 遺伝子改変マウス / 体温調節 / ストレス / 発熱物質 / 低温環境 / 小胞グルタミン酸輸送体-2 / 小胞グルタミン酸輸送体
Outline of Final Research Achievements

We examined possible roles of neurotransmitter (modulator) candidates contained in the hypothalamic orexin neurons during the defense response against stressors. We performed pharmacological experiment using blockers for the putative cotransmitters and physiological experiment using genetically engineered model mice (orexin knockout mice, orexin neuron-ablated mice, orexin neuron-specific vesicular glutamate transporter-2 knockout mice). We found that glutamate in the orexin neurons play a pivotal role in stress-induced hyperthermia, especially in its early phase, although glutamate was not involved in the basal control of the vigilance state and body temperature. Importance of glutamate in the stress-induced hyperthermia was evident in all the type of stressors so far tested.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (44 results)

All 2015 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (35 results) (of which Invited: 6 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Intermittent but not sustained hypoxia activates orexin-containing neurons in mice.2015

    • Author(s)
      Keiji Yamaguchi, Takahiro Futatsuki, Jumpei Ushikai, Chiharu Kuroki, Toshiaki Minami, Yasuyuki Kakihana, Tomoyuki Kuwaki
    • Journal Title

      Resp Physiol Neurobiol

      Volume: 206 Pages: 11-14

    • DOI

      10.1016/j.resp.2014.11.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice.2013

    • Author(s)
      Yoshiko Takahashi, Wei Zhang, Kohei Sameshima, Chiharu Kuroki, Ami Matsumoto, Jinko Sunanaga, Yu Kono, Takeshi Sakurai, Yuichi Kanmura, Tomoyuki Kuwaki
    • Journal Title

      Journal of Physiology

      Volume: 591 Issue: 22 Pages: 5623-5643

    • DOI

      10.1113/jphysiol.2013.261271

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 交感神経活動調節の中枢神経回路2013

    • Author(s)
      大塚曜一郎、桑木共之
    • Journal Title

      Cardiovascular Frontier

      Volume: 4 Pages: 15-20

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Journal Article] The impact of hypothermia on emergence from isoflurane anesthesia in orexin neuron-ablated mice2013

    • Author(s)
      Kuroki C., Takahashi Y., Ootsuka Y., Kanmura Y., Kuwaki T
    • Journal Title

      Anesthesia & Analgesia

      Volume: 116 Issue: 5 Pages: 1001-1005

    • DOI

      10.1213/ane.0b013e31828842f0

    • NAID

      120005447078

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ストレスと中枢性循環調節2012

    • Author(s)
      桑木共之
    • Journal Title

      呼吸と循環

      Volume: 60 Pages: 275-282

    • Related Report
      2012 Annual Research Report
  • [Presentation] Odorant X 誘発性鎮痛はストレス誘発性鎮痛とは異なる2015

    • Author(s)
      山口蘭、石川そでみ、田代章悟、加治屋勝子、上村裕一、桑木共之、柏谷英樹
    • Organizer
      第120回日本解剖学会総会・全国学術集会第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Odorant X 誘発性鎮痛の濃度依存性2015

    • Author(s)
      永田敬一朗、田代章悟、加治屋勝子、上村裕一、桑木共之、柏谷英樹
    • Organizer
      第120回日本解剖学会総会・全国学術集会第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 芋焼酎香気成分の一種odorant-Xによる匂い誘発性鎮痛の性質2015

    • Author(s)
      永田敬一朗、山口蘭、田代章悟、上村裕一、加治屋勝子、桑木共之、柏谷英樹
    • Organizer
      第5回鹿児島神経科学研究会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Year and Date
      2015-02-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 間欠的低酸素刺激はオレキシン神経を活性化する2015

    • Author(s)
      山口桂司、二木貴弘、牛飼純平、黒木千晴、桑木共之
    • Organizer
      第8回桜ヶ丘地区(基礎系)研究発表会
    • Place of Presentation
      鹿児島大学桜ヶ丘キャンパス
    • Year and Date
      2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鎮痛誘発香odorant Xに対してマウスはストレス応答を示さない2014

    • Author(s)
      石川そでみ、山口蘭、田代章悟、上村裕一、加治屋勝子、桑木共之、柏谷英樹
    • Organizer
      第42回自律神経生理研究会
    • Place of Presentation
      日本光電本社(東京都新宿区)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] ストレス防衛反応を担う神経伝達物質2014

    • Author(s)
      桑木共之
    • Organizer
      TUMEC45周年記念シンポジウム
    • Place of Presentation
      東京大学弥生キャンパス
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた自律神経機能を制御する神経回路の研究2014

    • Author(s)
      楠本-吉田郁恵、生駒葉子、岩元嘉志、迫はるか、大塚曜一郎、桑木共之
    • Organizer
      第67回日本自律神経学会総会
    • Place of Presentation
      ラフレさいたま(埼玉県さいたま市)
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The oder-induced antinociceptive effect is mediated by orexin neurons.2014

    • Author(s)
      Shogo Tashiro, Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki
    • Organizer
      15th World Congress on pain (IASP2014)
    • Place of Presentation
      La Rural Convention Center, Buenos Aires, Argentina
    • Year and Date
      2014-10-06 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視床下部オレキシンニューロンを介した匂い誘発性鎮痛の発現2014

    • Author(s)
      山口蘭,田代章悟,加治屋勝子,上村裕一,桑木共之,柏谷英樹
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of orexin neurons in the regulation of thermogenesis.2014

    • Author(s)
      Tomoyuki Kuwaki
    • Organizer
      International Symposium on physiology and pharmacology on temperature regulation (PPTR)
    • Place of Presentation
      Sukuza, Kruger National Park, South Africa
    • Year and Date
      2014-09-07 – 2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 視床下部オレキシン神経を介した匂い誘発性鎮痛の発現2014

    • Author(s)
      山口蘭、田代章悟、加治屋勝子、上村裕一、桑木共之、柏谷英樹
    • Organizer
      第4回鹿児島神経科学研究会
    • Place of Presentation
      鹿児島大学桜ヶ丘キャンパス
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Odor-induced analgesic effect in mice.2014

    • Author(s)
      Hideki Kashiwadani, Shogo Tashiro, Ran Yamaguchi, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki
    • Organizer
      FENS Forum 2014
    • Place of Presentation
      Mico Congress Centre, Milan, Italy
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 睡眠・覚醒に伴う呼吸調節の変化2014

    • Author(s)
      桑木共之
    • Organizer
      日本睡眠学会第39回定期学術集会基調シンポジウム
    • Place of Presentation
      徳島県郷土文化会館
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 嗅覚入力を介した鎮痛効果2014

    • Author(s)
      田代章悟、柏谷英樹、米満亨、上村裕一、桑木共之
    • Organizer
      第61回日本麻酔科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] INVOLVEMENT OF OREXIN IN METHAMPHETAMINE-INDUCED HYPOPHAGIA AND HYPERACTIVITY.2014

    • Author(s)
      Ikoma Y, Kuwaki T, Ootsuka Y
    • Organizer
      2014 Meeting of the Australasian Neuroscience Society
    • Place of Presentation
      Adelaide, Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] THE CONTRIBUTION OF OREXIN SYSTEM TO INTEGRATED ULTRADIAN PHYSIOLOGICAL PATTERN.2014

    • Author(s)
      Ootsuka Y, Miyata K, Ikoma Y, Kuwaki T, Yamanaka A
    • Organizer
      2014 Meeting of the Australasian Neuroscience Society
    • Place of Presentation
      Adelaide, Australia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Odor-induced analgesia in mouse2014

    • Author(s)
      柏谷英樹、田代章悟、上村裕一、桑木共之
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オレキシン神経は嗅覚入力による抗侵害受容作用に関与する2014

    • Author(s)
      田代章悟、柏谷英樹、上村裕一、桑木共之
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] Orexin contributes to feeding and drinking behavior induced by methamphetamine2014

    • Author(s)
      生駒葉子、桑木共之、大塚曜一郎
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] オレキシンニューロンに共存するグルタミン酸はストレス誘発性熱産生に重要である2013

    • Author(s)
      松元愛海
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] オレキシンニューロンに共存するグルタミン酸はストレス誘発性熱産生に重要である2013

    • Author(s)
      松元愛海
    • Organizer
      第2回脳・肝インターフェイスメディシン研究センター
    • Place of Presentation
      東京
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] オレキシンニューロン破壊マウスにおけるイソフルラン麻酔からの覚醒に与える低体温の影響2013

    • Author(s)
      黒木千晴、高橋佳子、上村裕一、桑木共之
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Impact of hypothermia on emergence from isoflurane anesthesia in orexin neuron ablated mice.2013

    • Author(s)
      Kuroki C., Takahashi Y., Kanmura Y., Kuwaki T.
    • Organizer
      EuroAnesthasia 2013
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] オレキシンニューロン欠損による麻酔覚醒の遷延には低体温の影響が大きい2013

    • Author(s)
      黒木千晴、高橋佳子、上村裕一、桑木共之
    • Organizer
      日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] A role of glutamate co-released from orexin neurons in methamphetamine-induced autonomic physiological response.2013

    • Author(s)
      Y.Ikoma, K. Miyata, T. Kuwaki, Y.Y.Ootsuka
    • Organizer
      IUPS 2013
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ultradian basic rest-activity cycle in orexin deficien mice2012

    • Author(s)
      K. Miyata
    • Organizer
      42nd SfN Meeting (Neuroscience 2012)
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] オレキシンニューロンにおけるグルタミン酸の神経伝達物質としての役割2012

    • Author(s)
      松元愛海
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中枢性体温調節回路におけるオレキシン神経細胞の役割2012

    • Author(s)
      桑木共之
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] SIDS FROM NEUROPHYSIOLOGY2012

    • Author(s)
      Tomoyuki Kuwaki
    • Organizer
      22nd Conference of the International Academy ofLegal Medicine
    • Place of Presentation
      Istanbul (Turkey)(招待講演)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] ストレスと自律機能2012

    • Author(s)
      桑木共之
    • Organizer
      日本睡眠学会第37回定期学術集会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 睡眠・覚醒・ストレスに伴う体内環境調整におけるオレキシン神経の役割2012

    • Author(s)
      桑木共之
    • Organizer
      第590回北里医学会招待学術講演会
    • Place of Presentation
      北里大学(神奈川)(招待講演)
    • Year and Date
      2012-05-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of orexin neurons in prostaglandin E2-induced fever and the defenseagainst environmental cooling2012

    • Author(s)
      Tomoyuki Kuwaki
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-04-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] オレキシン神経は嗅覚入力による抗侵害受容作用に関与する

    • Author(s)
      田代章悟、柏谷英樹、上村裕一、桑木共之
    • Organizer
      第41回自律神経生理研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] オレキシン神経は匂い誘発性鎮痛に関与する

    • Author(s)
      田代章悟、柏谷英樹、上村裕一、桑木共之
    • Organizer
      第7回桜ヶ丘地区(基礎系)研究会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] メタンフェタミン経口投与で生じる生理反応におけるオレキシン神経の役割

    • Author(s)
      生駒葉子、桑木共之、大塚曜一郎
    • Organizer
      第9回環境生理プレコングレス
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Book] SLEEP HORMONES (volume 89 of Vitamins & Hormones)2012

    • Author(s)
      Tomoyuki Kuwaki
    • Total Pages
      370
    • Publisher
      Academic Press, New York
    • Related Report
      2012 Annual Research Report
  • [Remarks] 鹿児島大学大学院医歯学総合研究科 統合分子生理学分野ホームページ

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~physiol1/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 鹿児島大学大学院医歯学総合研究科 統合分子生理学分野ホームページ

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~physiol1/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~physioll/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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