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Molecular pathological analyses of Wnt5a-Ror signaling in inflammation and cancer progression accompanying epithelial-mesenchymal transition

Research Project

Project/Area Number 24390080
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pathological medical chemistry
Research InstitutionKobe University

Principal Investigator

MINAMI Yasuhiro  神戸大学, 医学(系)研究科(研究院), 教授 (70229772)

Co-Investigator(Kenkyū-buntansha) NISHITA Michiru  神戸大学, 大学院医学研究科, 准教授 (30379359)
ENDO Mitsuharu  神戸大学, 大学院医学研究科, 助教 (90436444)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
KeywordsWnt5a-Ror / シグナル伝達 / 上皮間葉転換 (EMT) / 慢性炎症 / がんの増悪 / 組織損傷修復 / 炎症性サイトカイン / Wnt5a-Rorシグナル / 上皮間葉転換 / 炎症 / がんの進展・増悪 / 遺伝子発現制御 / 癌
Outline of Final Research Achievements

Wnt5a-Ror signaling has been shown to be activated transiently during embryogenesis and to play important roles in developmental morphogenesis and tissue-genesis via induction of epithelial-mesenchymal transition and so on. After birth, expression levels of Wnt5a and Ror proteins are very low in general. In this study, we have shown by employing in vitro and in vivo analyses that these proteins are induced during tissue repair after injury, chronic inflammation, and progression of cancers, thereby resulting in aberrant activation of Wnt5a-Ror signaling. We have also found possible relationships between these pathological conditions and aberrant activation of Wnt5a-Ror signaling.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (30 results)

All 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Invited: 3 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Insight into the role of Wnt5a-induced signaling in normal and cancer cells.2015

    • Author(s)
      Endo, M., Nishita, M., Fujii, M., Minami, Y.
    • Journal Title

      Int. Rev. Cell Mol. Biol.

      Volume: 314 Pages: 117-148

    • DOI

      10.1016/bs.ircmb.2014.10.003

    • ISBN
      9780128022832
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-g in colitis.2015

    • Author(s)
      Sato, A., Kayama, H., Shojima, K., Matsumoto, S., Koyama, H., Minami, Y., Nojima, S., Morii, E., Honda, H., Takeda, K., Kikuchi, A.
    • Journal Title

      Sci. Report

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene2014

    • Author(s)
      Mori K, Kitazawa R, Kondo T, Mori M, Hamada Y, Nishida M, Minami Y, Haraguchi R, Takahashi Y, Kitazawa S.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 7 Pages: e102797-e102797

    • DOI

      10.1371/journal.pone.0102797

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding2014

    • Author(s)
      Nishita M, Qiao S, Miyamoto M, Okinaka Y, Yamada M, Hashimoto R, Iijima K, Otani H, Hartmann C, Nishinakamura R, Minami Y
    • Journal Title

      Mol Cell Biol

      Volume: 34 Issue: 16 Pages: 3096-3105

    • DOI

      10.1128/mcb.00491-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical role of Frizzledl in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.2014

    • Author(s)
      Doi R, Endo M, Yamakoshi K, Y amanashi Y, Nishita M, Fukada SI. Minami Y.
    • Journal Title

      Genes Cells.

      Volume: 19 Issue: 4 Pages: 287-296

    • DOI

      10.1111/gtc.12132

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-6-accelerated calcification by induction of Ror2 in human adipose tissue-derived mesenchymal stem cells is STAT3-dependent.2014

    • Author(s)
      Fukuyo, S., Yamaoka, K., Sonomoto, K., Oshita, K., Okada, Y., Saito, K., Yoshida, Y., Kanazawa, T., Minami, Y., Tanaka, Y.
    • Journal Title

      Rheumatology

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014

    • Author(s)
      Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
    • Journal Title

      Sci. report

      Volume: 4 Issue: 1 Pages: 4493-4493

    • DOI

      10.1038/srep04493

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis.2013

    • Author(s)
      Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., Minami, Y.
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 7 Pages: 608-619

    • DOI

      10.1111/gtc.12064

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex2012

    • Author(s)
      Endo M, Doi R, Nishita M, Minami Y
    • Journal Title

      Journal of Cell Science

      Volume: (印刷中)(掲載確定) Pages: 2017-2029

    • DOI

      10.1242/jcs.097782

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非古典的Wntシグナルによる極性と幹細胞性維持の制御2012

    • Author(s)
      遠藤光晴、南康博
    • Journal Title

      生体の科学(特集 : 細胞極性の制御)

      Volume: 63 Pages: 224-228

    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of NF-κB-mediated expression of Ror1 during skeletal muscle regeneration2014

    • Author(s)
      Koki Kamisaki, Ryosuke Doi, Suguru Kato, Soichiro Fukada, Motoi Kanagawa, Tatsushi, Mitsuharu Endo, Yasushiro Minami
    • Organizer
      UNIVERSITY OF WASHINGTON-KOBE UNIVERSITY INTERNATIONAL SYMPOSIUM ON MEMBRANE BIOLOGY
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2014-12-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 受容体型チロシンキナーゼRor1による骨格筋再生制御2014

    • Author(s)
      加藤 英、土井 亮助、遠藤 光晴、深田 宗一郎、金川 基、戸田 達史、南 康博
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of Wnt5a-Ror2 signaling in patterning the metanephric mesenchyme during ureteric budding2014

    • Author(s)
      Michiru Nishita, Sen Qiao, Mari Miyamoto, Yuka Okinaka, Makiko Yamada, Ryuju Hashimoto, Kazumoto Iijima, Hiroki Otani, Christine Hartmann, Ryuichi Nishinakamura, Yasuhiro Minami
    • Organizer
      Keystone Symposia "Developmental Pathways and Cancer: Wnt, Notch and Hedgehog(J7)"
    • Place of Presentation
      Banff, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Roles of Wnt5a-Ror Signaling in Pathological Conditions2014

    • Author(s)
      Yasuhiro Minami
    • Organizer
      UNIVERSITY OF WASHINGTON-KOBE UNIVERSITY SYMPOSIUM ON MEMBRANE BIOLOGY
    • Place of Presentation
      UW, Seattle, U.S.A.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 筋損傷・再生過程における受容体型チロシンキナーゼRor1の発現解析2013

    • Author(s)
      土井 亮助、遠藤 光晴、南 康博
    • Organizer
      第60回日本生化学会近畿支部例会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Roles of Wnt/PCP signaling in pathological conditions of epithelial tubular tissues2013

    • Author(s)
      Yasuhiro Minami, Kaoru Yamagata, Mitsuharu Endo, Hiroki Otani, Ryuichi Nishinakamura, Michiru Nishita
    • Organizer
      First International Meeting for Epithelial Tubulology
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 炎症性サイトカインによりアストロサイトで発現誘導されるRor1受容体の機能解析2013

    • Author(s)
      遠藤 光晴、土井 亮助、西田 満、南 康博
    • Organizer
      2013年度包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 尿管芽形成におけるWnt5a-Ror2シグナルの役割と腎尿路奇形2013

    • Author(s)
      西田 満, 喬 森,宮本 真里, 沖中 由佳, 山田 真紀子, 飯島 一誠, 大谷 浩, Christine Hartmann, 西中村 隆一, 南 康博
    • Organizer
      第22回発達腎研究会
    • Place of Presentation
      大阪(高槻)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional analysis of Wnt5a-Ror signaling in regulation of progenitor proliferation during neocortical neurogenesis2013

    • Author(s)
      Mtisuharu Endo, Yasuhiro Minami
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, U.S.A.
    • Related Report
      2013 Annual Research Report
  • [Presentation] 反応性アストロサイトにおけるRorファミリー受容体型チロシンキナーゼの役割2013

    • Author(s)
      遠藤 光晴、加藤 英、疋田 壮舞、南 康博
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨格筋分化・再生モデルを用いたRorシグナルの機能解析2012

    • Author(s)
      土井亮介、遠藤光晴、南康博
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス腎臓発生におけるWnt5a-Ror2シグナルの役割2012

    • Author(s)
      西田満、喬森、宮本真理、山田真紀子、大谷浩、Christine Hartmann、西中村隆一、南康博
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Book] ROR Receptor Tyrosine Kinase Family (Chapter 13) Receptor Tyrosine Kinases: Family and subfamilies2015

    • Author(s)
      Endo, M., Nishita, M., Doi, R., Hayashi, M., Minami, Y.
    • Publisher
      Springer Science
    • Related Report
      2014 Annual Research Report
  • [Book] The Receptor Tyrosine Kinase Handbook2014

    • Author(s)
      Endo, M., Nishita, M., Doi, R., Minami, Y. (Wheeler, D. L., Yarden, Y. edited)
    • Publisher
      Springer Science
    • Related Report
      2013 Annual Research Report
  • [Book] Progenitor Cells: Biology, Characterization and Potential Clinical Applications2013

    • Author(s)
      Endo, M., Minami, Y. (Horton, P. M., Lawrence, B. E. edited)
    • Total Pages
      16
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2013 Annual Research Report
  • [Book] The Receptor Tyrosine Kinase Handbook (chapter : Ror receptor family)2013

    • Author(s)
      Endo, M., Nishita, M., Doi, R., Minami, Y.
    • Publisher
      Springer Science(印刷中) (掲載確定)
    • Related Report
      2012 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.med.kobe-u.ac.jp/medzoo/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.med.kobe-u.ac.jp/medzoo/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 新学術領域ホームページ

    • URL

      http://www.med.osaka-u.ac.jp/pub/molbiobc/tubulology/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/medzoo/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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