| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
NKG2D ligands are a group of major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They act as a danger signal alerting the immune system to the presence of abnormal cells. In this project, we analyzed the function of H60c, a mouse NKG2D ligand assumed to be involved in the immune surveillance and maintenance of homeostasis at body surfaces. We also analyzed the expression of NKG2D ligands in human cancer.
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