| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Recently, the presence of an organelle, PLV/VAC, which forms only in extracellular environment and is important for the adaptation in it, was reported in Toxoplasma gondii. We identified this organelle independently and found it can classify three subcompartments.
We also found that one of the antimalarial drug, primaquine, releases H+ and Ca2+ from one of these three, PLV2, to the cytosol of T. gondii. We established primaquine-resistant T. gondii mutants and identified the responsible gene.
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