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Cross-reactive antibodies to influenza virus hemagglutinins and their epitopes

Research Project

Project/Area Number 24390110
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Virology
Research InstitutionHokkaido University

Principal Investigator

Takada Ayato  北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)

Co-Investigator(Renkei-kenkyūsha) ITO Kimihito  北海道大学, 人獣共通感染症リサーチセンター, 教授 (60396314)
IGARASHI Manabu  北海道大学, 人獣共通感染症リサーチセンター, 准教授 (10374240)
Research Collaborator YOSHIDA Reiko  
MURAMATSU Mieko  
MIYAMOTO Hiroko  
Wilson Ian  
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywordsウイルス / インフルエンザ / 亜型 / 抗体 / 中和 / 感染防御 / 感染症 / インフルエンザウイルス / ヘマグルチニン / 亜型間交差 / 感染性中和
Outline of Final Research Achievements

By focusing on a novel antiviral function (budding inhibition), we found potential roles of anti-hemagglutinin antibodies in cross-protective immunity against influenza A viruses with multiple HA subtypes. It was particularly noted that the comparison between IgG and IgA antibodies recognizing the same epitope on the HA molecule clearly demonstrated the greater potential of HA-specific IgA than IgG antibodies in antiviral activities. It was also attempted to modify antibody specificity by structure-based molecular simulation and production of recombinant antibodies.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (45 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (15 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 15 results,  Acknowledgement Compliant: 1 results,  Open Access: 5 results) Presentation (29 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results)

  • [Int'l Joint Research] The Scripps Research Institute(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Genetic predisposition to acquire a polybasic cleavage site for highly pathogenic avian influenza virus hemagglutinin2017

    • Author(s)
      Nao N, Yamagishi J, Miyamoto H, Igarashi M, Manzoor R, Ohnuma A, Tsuda Y, Furuyama W, Shigeno A, Kajihara M, Kishida N, Yoshida R, Takada A
    • Journal Title

      MBio

      Volume: 8 Issue: 1 Pages: 1-15

    • DOI

      10.1128/mbio.02298-16

    • NAID

      120006337761

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense.2016

    • Author(s)
      Yamada T, Horimoto H, Kameyama T, Hayakawa S, Yamato H, Dazai M, Takada A, Kida H, Bott D, Zhou AC, Hutin D, Watts TH, Asaka M, Matthews, Takaoka A
    • Journal Title

      Nat Immunol.

      Volume: 印刷中 Issue: 6 Pages: 687-694

    • DOI

      10.1038/ni.3422

    • NAID

      120005849912

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Characterization of the glycoproteins of bat-derived influenza viruses.2016

    • Author(s)
      Maruyama J, Nao N, Miyamoto H, Maeda K, Ogawa H, Yoshida R, Igarashi M, Takada A
    • Journal Title

      Virology

      Volume: 488 Pages: 43-50

    • DOI

      10.1016/j.virol.2015.11.002

    • NAID

      120005906991

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic and antigenic characterization of H5 and H7 influenza viruses isolated from migratory water birds in Hokkaido, Japan and Mongolia from 2010 to 20142015

    • Author(s)
      Hiono T, Ohkawara A, Ogasawara K, Okamatsu M, Tamura T, Chu DH, Suzuki M, Kuribayashi S, Shichinohe S, Takada A, Ogawa H, Yoshida R, Miyamoto H, Nao N, Furuyama W, Maruyama J, Eguchi N, Ulziibat G, Enkhbold B, Shatar M, Jargalsaikhan T, Byambadorj S, Damdinjav B, Sakoda Y, Kida H.
    • Journal Title

      Virus Genes

      Volume: 51 (1) Issue: 1 Pages: 57-68

    • DOI

      10.1007/s11262-015-1214-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Single Amino Acid in the M1 Protein Responsible for the Different Pathogenic Potentials of H5N1 Highly Pathogenic Avian Influenza Virus Strains2015

    • Author(s)
      Nao N, Kajihara M, Manzoor R, Maruyama J, Yoshida R, Muramatsu M, Miyamoto H, Igarashi M, Eguchi N, Sato M, Kondoh T, Okamatsu M, Sakoda Y, Kida H, Takada A
    • Journal Title

      PLoS One

      Volume: 10(9) Issue: 9 Pages: e0137989-e0137989

    • DOI

      10.1371/journal.pone.0137989

    • NAID

      120005672370

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of the PB2 and M genes on the replication of H6 influenza virus in chickens2014

    • Author(s)
      Ozaki H, Guan Y, Peiris M, Webster R, Takada A, Webby R
    • Journal Title

      Influenza. Res. Treat.

      Volume: 該当しない Pages: 547839-547839

    • DOI

      10.1155/2014/547839

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The zoonotic potential of avian influenza viruses isolated from wild waterfowl in Zambia2014

    • Author(s)
      Simulundu E, Nao N, Yabe J, Muto NA, Sithebe T, Sawa H, Manzoor R, Kajihara M, Muramatsu M, Ishii A, Ogawa H, Mweene AS, Takada A
    • Journal Title

      Arch. Virol.

      Volume: 159 Issue: 6 Pages: 2633-2640

    • DOI

      10.1371/journal.ppat.1004192

    • NAID

      120005656330

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel mutations in Marburg virus glycoprotein associated with viral evasion from antibody mediated immune pressure.2013

    • Author(s)
      Kajihara, M., et al.
    • Journal Title

      Journal of general virology

      Volume: 94 Issue: 4 Pages: 876-883

    • DOI

      10.1099/vir.0.049114-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The genetic and antigenic diversity of avian influenza viruses isolated from domestic ducks, muscovy ducks, and chickens in northern and southern Vietnam, 2010-20122013

    • Author(s)
      Okamatsu M, Nishi T, Nomura N, Yamamoto N, Sakoda Y, Sakurai K, Chu HD, Thanh LP, Van Nguyen L, Van Hoang N, Tien TN, Yoshida R, Takada A, Kida H
    • Journal Title

      Virus Genes

      Volume: 47 Issue: 2 Pages: 317-329

    • DOI

      10.1007/s11262-013-0954-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterosubtypic antiviral activity of hemagglutinin-specific antibodies induced by intranasal immunization with inactivated influenza viruses in mice.2013

    • Author(s)
      Muramatsu M. et al.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e71534-e71534

    • DOI

      10.1371/journal.pone.0071534

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Antiviral Activity between IgA and IgG Specific to Influenza Virus Hemagglutinin: Increased Potential of IgA for Heterosubtypic Immunity2013

    • Author(s)
      Muramatsu M, Yoshida R, Yokoyama A, Miyamoto H, Kajihara M, Maruyama J, Nao N, Manzoor R, Takada A
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 1 Pages: e85582-e85582

    • DOI

      10.1371/journal.pone.0085582

    • NAID

      120005425353

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity2013

    • Author(s)
      Manzoor R, Kuroda K, Yoshida R, Tsuda Y, Fujikura D, Miyamoto H, Kajihara M, Kida H, Takada A
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 11 Pages: 7599-7614

    • DOI

      10.1074/jbc.m113.507798

    • NAID

      120005460233

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced bv avidity.2012

    • Author(s)
      Lee PS, Yoshida R, Ekiert DC, Sakai N, Suzuki Y, Takada A, Wilson IA.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Issue: 42 Pages: 13467-13474

    • DOI

      10.1073/pnas.1212371109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Marburg virus budding by nonneutralizing antibodies to the envelope glycoprotein.2012

    • Author(s)
      Kajihara M, Marzi A, Nakayama E, Noda T, Kuroda M, Manzoor R, Matsuno K, Feldmann
    • Journal Title

      J Virol

      Volume: 86 Pages: 13467-13474

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of an M2-specific monoclonal antibody on different strains of influenza A virus.2012

    • Author(s)
      Muto NA, Yoshida R, Suzuki T, Kobayashi s, Ozaki H, Fujikura D, Manzoor R, Muramatsu M, Takada A, Kimura T, Sawa H.
    • Journal Title

      Jpn J Vet Res

      Volume: 60 Pages: 71-83

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genetic Predisposition to Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin/インフルエンザウイルスヘマグルチニン開裂部位への塩基性アミノ酸挿入メカニズム解2016

    • Author(s)
      Naganori Nao, Junya Yamagishi, Hiroko Miyamoto, Manabu Igarashi, Rashid Manzoor, Aiko Ohnuma, Yoshimi Tsuda, Wakako Furuyama, Masahiro Kajihara, Reiko Yoshida, Ayato Takada
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌市、日本)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Computational analysis of a conformational epitope of a broadly neutralizing antibody in influenza A virus hemagglutinin2016

    • Author(s)
      Manabu Igarashi,Masakazu Sekijima,Nobuaki Yasuo,Takashi Abe,Reiko Yoshida,Hiroaki Tokiwa,Teruaki Watabe,Takatsugu Hirokawa,Ayato Takada
    • Organizer
      Options IX for the Control of Influenza
    • Place of Presentation
      Sheraton Grand Chicago Hotel (Chicago, USA)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A genetic basis for the acquisition of basic amino acid residues at the cleavage site of influenza virus hemagglutinin2016

    • Author(s)
      Naganori Nao, Junya Yamagishi, Hiroko Miyamoto, Aiko Ohnuma, Wakako Furuyama, Yoshimi Tsuda, Rashid Manzoor, Reiko Yoshida, Manabu Igarashi, Ayato Takada
    • Organizer
      Options IX for the Control of Influenza
    • Place of Presentation
      Sheraton Grand Chicago Hotel (Chicago, USA)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人獣共通感染症としてのインフルエンザ2016

    • Author(s)
      高田礼人
    • Organizer
      第24回呼吸器疾患・感染症研究会
    • Place of Presentation
      泉ガーデンタワー(東京港区、日本)
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 人獣共通感染症研究最前線 -エボラ出血熱とインフルエンザ-2016

    • Author(s)
      高田礼人
    • Organizer
      第45回野依フォーラム例会
    • Place of Presentation
      名古屋大学 野依記念物質科学研究館(名古屋市、日本)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Characterization of the glycoproteins of bat-derived influenza viruses2015

    • Author(s)
      Junki Maruyama,Naganori Nao,Hiroko Miyamoto,Ken Maeda,Hirohito Ogawa,Reiko Yoshida,Manabu Igarashi,Ayato Takada
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市、日本)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characterization of the hemagglutinin of bat-derived influenza viruses2015

    • Author(s)
      Junki Maruyama, Nao Naganori, Hiroko Miyamoto, Ken Maeda, Hirohito Ogawa, Reiko Yoshida, Ayato Takada
    • Organizer
      Sixteenth International Conference on Negative Strand Viruses
    • Place of Presentation
      Auditorium Department of Law (Siena, Italy)
    • Year and Date
      2015-06-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of Antiviral Activity Between IgA and IgG Specific to Influenza Virus Hemagglutinin: Increased Potential of IgA for Heterosubtypic Immunity2015

    • Author(s)
      Ayato Takada
    • Organizer
      Acute Respiratory Infections (ARI) Panel Meeting, 17th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim Emerging Viral Diseases, United States-Japan
    • Place of Presentation
      Academia Sinica (Taipei, Taiwan)
    • Year and Date
      2015-01-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] H5N1 インフルエンザウイルスに対する中和抗体を用いた受動免疫の感染防御効果2014

    • Author(s)
      吉田玲子、伊藤靖、七戸新太郎、小笠原一誠、日尾野隆大、岡松正敏、迫田義博、喜田宏、Mai Quynh Le、河岡義裕、五十嵐学、鈴木定彦、高田礼人
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市、日本)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] A 型インフルエンザウイルスヘマグルチニン特異的IgA 抗体の亜型間交差抗ウイルス活性2014

    • Author(s)
      村松美笑子、吉田玲子、横山文香、宮本洋子、梶原将大、丸山隼輝、直享則、Rashid Manzoor、高田礼人
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市、日本)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of antiviral activity between IgA and IgG: High potential of IgA antibodies specific to influenza virus hemagglutinin for heterosubtypic immunity2014

    • Author(s)
      Mieko Muramatsu, Reioko Yoshida, Ayaka Yokoyama, Hiroko Miyamoto, Masahiro Kajihara, Junki Maruyama, Naganori Nao, Rashid Manzoor, Ayato Takada
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      奈良県新公会堂(奈良市、日本)
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neutralizing monoclonal antibody therapy for H5N1 highly pathogenic avian influenza virus infection in animal models2014

    • Author(s)
      Reiko Yoshida, Yasushi Itoh, Shintaro Shichinohe, Kazumasa Ogasawara, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Quynh Mai Le, Yoshihiro Kawaoka, Manabu Igarashi, Yasuhiko Suzuki, Ayato Takada
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      奈良県新公会堂(奈良市、日本)
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Correlates of Hsp70 kinetics and influenza A virus polymerase activity2014

    • Author(s)
      Rashid Manzoor, Kazumichi Kuroda, Reiko Yoshida, Yoshimi Tsuda, Daisuke Fujikura, Hiroko Miyamoto, Masahiro Kajihara, Hiroshi Kida, Ayato Takada
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      奈良県新公会堂(奈良市、日本)
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of antiviral activity between IgA and IgG2014

    • Author(s)
      Mieko Muramatsu, ReikoYoshida, Ayato Takada
    • Organizer
      XVI International Congress of Virology
    • Place of Presentation
      Montreal Convention Centre (Montreal, Canada)
    • Year and Date
      2014-07-28 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Different pathogenicity of H5N1 highly pathogenic avian influenza viruses determined by a single amino acid in the M1 protein2014

    • Author(s)
      Naganori Nao, Masahiro Kajihara, Junki Maruyama, Takashi Kimura, Rashid Manzoor, Mieko Muramatsu, Reiko Yoshida, Masatoshi Okamatsu, Hiroshi Kida, Ayato Takada
    • Organizer
      XVI International Congress of Virology
    • Place of Presentation
      Montreal Convention Centre (Montreal, Canada)
    • Year and Date
      2014-07-28 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鳥インフルエンザの基礎2014

    • Author(s)
      高田礼人
    • Organizer
      第12回インフルエンザ夏季セミナー
    • Place of Presentation
      第一ホテル東京(東京都港区、日本)
    • Year and Date
      2014-07-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルスヘマグルチニン特異抗体の亜型間交差反応性2012

    • Author(s)
      村松美笑子、吉田玲子、宮本洋子、高田礼人
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2012-11-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗体によるマールブルグウイルスの出芽阻害2012

    • Author(s)
      梶原将大、Marzi Andrea、中山絵里、野田岳志、黒田誠、Manzoor Rashid、Feldmann Heinz、吉田玲子、河岡義裕、高田礼人
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2012-11-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 不活化インフルエンザウイルス接種によって誘導されるヘマグルチニン特異抗体の亜型間交2012

    • Author(s)
      村松美笑子、吉田玲子、宮本洋子、高田礼人
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学、盛岡
    • Year and Date
      2012-09-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗体によるマールブルグウイルスの出芽阻害2012

    • Author(s)
      梶原将大、Andrea Marzi、中山絵里、野田岳志、黒田誠、Rashid Manzoor,松野啓太、Heinz Feldmann、吉田玲子、河岡義裕、高田礼人
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学、盛岡
    • Year and Date
      2012-09-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Heterosubtypic binding activity of hemagglutinin-specific antibodies induced by inoculation of inactivated influenza virus in mice2012

    • Author(s)
      Mieko Muramatsu, Reiko Yoshida, Ayato Takada
    • Organizer
      The 9th Japan-China International Conference of Virology
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2012-06-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Modulatory effect of heat shock protein 70 (Hsp70) on influenza A virus polymerase activity

    • Author(s)
      Rashid Manzoor, Kazumichi Kuroda, Reiko Yoshida, Yoshimi Tsuda, Daisuke Fujikura, Hiroko Miyamoto, Masahiro Kajihara, Hiroshi Kida, Ayato Takada
    • Organizer
      Fifteenth International Conference on Negative Strand Viruses
    • Place of Presentation
      Palacio de Exposiciones y Congresos, Granada (Spain)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heterosubtypic antiviral activity of influenza virus

    • Author(s)
      Mieko Muramatsu, ReikoYoshida, Ayato Takada
    • Organizer
      Fifteenth International Conference on Negative Strand Viruses
    • Place of Presentation
      Palacio de Exposiciones y Congresos, Granada (Spain)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pathogenicity of H5N1 highly pathogenic avian influenza virus in wild ducks and herons

    • Author(s)
      Kosuke Soda, Tatsufumi Usui1, Yukiko Uno, Yasuko Nagai, Hiroichi Ozaki, Hiroshi Ito, Naoki Yamamoto, Tomokazu Tamura, Takahiro Hiono, Masatoshi Okamatsu, Yoshihiro Sakoda, Ayato Takada, Tsuyoshi Yamaguchi, Toshihiro Ito
    • Organizer
      Fifteenth International Conference on Negative Strand Viruses
    • Place of Presentation
      Palacio de Exposiciones y Congresos, Granada (Spain)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A formula on the number of amino acid substitutions on the hemagglutinin molecules of H3N2 seasonal influenza viruses

    • Author(s)
      Kimihito Ito, Manabu Igarashi, Ayato Takada
    • Organizer
      Fifteenth International Conference on Negative Strand Viruses
    • Place of Presentation
      Palacio de Exposiciones y Congresos, Granada (Spain)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 2010年に稚内で分離された2株の高病原性鳥インフルエンザウイルスの病原性比較

    • Author(s)
      直亨則、梶原将大、丸山隼輝、木村享史、Manzoor Rashid、村松美笑子、岡松正敏、宮本洋子、吉田玲子、迫田義博、喜田宏、高田礼人
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PB2 Protein of a Highly Pathogenic Avian Influenza Virus Strain A/chicken/Yamaguchi/7/2004 (H5N1) Determines Its Replication Potential in Pigs

    • Author(s)
      Rashid Manzoor, Yoshihiro Sakoda, Naoki Nomura, Yoshimi Tsuda, Hiroichi Ozaki, Masatoshi Okamatsu, Ayato Takada, Hiroshi Kida
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 計算科学手法を用いたインフルエンザウイルスヘマグルチニンと亜型間交差反応性抗体との分子間相互作用の解析

    • Author(s)
      五十嵐学、吉田玲子、関嶋政和、常盤広明、喜田宏、伊藤公人、高田礼人
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ecology of Avian Influenza Viruses: Topics from surveillance in Asia and Africa

    • Author(s)
      Ayato Takada
    • Organizer
      1st Kyoto International Symposium on Virus-Host Coevolution
    • Place of Presentation
      Shiran-Kaikan(京都市)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2012-04-24   Modified: 2019-07-29  

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