| Project/Area Number |
24390119
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | University of Toyama |
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Principal Investigator |
TAKATSU Kiyoshi 富山大学, 大学院医学薬学研究部(医学), 客員教授 (10107055)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 客員准教授 (30431761)
IKUTANI Masashi 富山大学, 大学院医学薬学研究部(医学), 客員講師 (40513718)
刈米 アイ 富山大学, 大学院・医学薬学研究部, 客員助教 (50114450)
小笠原 勝 富山県薬事研究所, 主任研究員 (30443427)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | サイトカイン / 自然免疫 / 粘膜免疫 / 免疫監視・腫瘍免疫 / 好酸球 |
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| Outline of Final Research Achievements |
In this study, we investigated the roles of innate IL-5-producing cells in the lung and the intestine by taking advantage of IL-5/Venus knock-in mice. In response to IL-25 or IL-33, innate IL-5-producing cells rapidly produced IL-5 and IL-13. These cells were localized around bronchus and bronchioles and recruited eosinophil into the lung, suggesting that innate IL-5-producing cells play a critical role in the pathogenesis of allergic conditions. Innate IL-5-producing cells in the lung also contributed to anti-tumor immunity via eosinophil regulation. On the other hand, in the large intestine, innate IL-5-producing cells contributed to T cell-independent IgA production.
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