• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Suppression mechanisms of autoimmune diseases by SATB1

Research Project

Project/Area Number 24390121
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Immunology
Research InstitutionToho University

Principal Investigator

KONDO Motonari  東邦大学, 医学部, 教授 (20594344)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA Fumio  東邦大学, 医学部, 講師 (10130345)
TANAKA Yuriko  東邦大学, 医学部, 助教 (40396685)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords自己免疫疾患 / 免疫寛容 / T細胞 / ネガティブセレクション / 自己免疫
Outline of Final Research Achievements

Immune tolerance is maintained in the healthy condition; however, autoimmune diseases occur once immune tolerance is broken. We found that loss of a genome organiser, Special AT-rich binding protein-1 (SATB1), leads to autoimmune diseases in mice. In SATB1 deficient mice, negative selection, in which auto-reactive T cells are eliminated, is impaired. Therefore, SATB1 plays a critical role in establishment of immune tolerance.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results)

  • [Journal Article] Thymic precursors of TCRab+CD8aa+ intraepithelial lymphocytes are negative for CD1032015

    • Author(s)
      Xianghua Guo, Yuriko Tanaka, Motonari Kondo
    • Journal Title

      Immuology Letters

      Volume: 163 Issue: 1 Pages: 40-48

    • DOI

      10.1016/j.imlet.2014.11.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development2015

    • Author(s)
      Bingtao Hao, Abani Kanta Naik , Akiko Watanabe , Hirokazu Tanaka , Liang Chen , Hunter W Richards, Motonari Kondo, Ichiro Taniuchi, Yoshinori Kohwi, Terumi Kohwi-Shigematsu, Michael S Krangel
    • Journal Title

      Journal of experimental medicine

      Volume: 212 Issue: 5 Pages: 809-824

    • DOI

      10.1084/jem.20142207

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.2013

    • Author(s)
      Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y.
    • Journal Title

      Immunity

      Volume: 38 Issue: 6 Pages: 1105-1115

    • DOI

      10.1016/j.immuni.2013.05.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Y-chromosome-linked B- and NK-cell deficiency in mice2013

    • Author(s)
      Sun SL, Horino S, Itoh-Nakadai A, Kawabe T, Asao A, Takahashi T, So T, Funayama R, Kondo M, Saitsu H, Matumoto N, Nakayama K, and Ishii N
    • Journal Title

      J. Immunol.

      Volume: 190 Issue: 12 Pages: 6209-6220

    • DOI

      10.4049/jimmunol.1300303

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] The function of SATB1 in a mouse model for sjogren's syndrome2014

    • Author(s)
      Yuriko Tanaka, Takehiko Sotome, Taku Kuwabra, Yasushi Akiba, Motonari Kondo
    • Organizer
      43rd,The annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      国立京都国際会館 京都府 京都市
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] SATB1 is required for development of experimental autoimmune encephalomyelitis2014

    • Author(s)
      Taku Kuwabara, Yasushi Akiba, Yuriko Tanaka, Taku Naito, Motonari Kondo
    • Organizer
      43rd,The annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      国立京都国際会館 京都府 京都市
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 免疫寛容における分子制御機構の解析2014

    • Author(s)
      田中ゆり子, グオシャンファ, 向津隆規, 早乙女壮彦, 桑原卓, 近藤元就
    • Organizer
      Kyoto T cell Conference 第24回学術集会
    • Place of Presentation
      京都平安ホテル 京都府 京都市
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] SATB1遺伝子欠損マウスにおける自己免疫疾患の病態解析2014

    • Author(s)
      早乙女壮彦, 渡邊美砂, 正田八州穂, 小峰由美子, 田中ゆり子, 郭向華, 近藤元就, 佐地勉
    • Organizer
      第26回 日本アレルギー学会春季臨床大会
    • Place of Presentation
      国立京都国際会館 京都府 京都市
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of SATB1 in mouse model of autoimmune disease.2013

    • Author(s)
      Mukozu T., Guo X., Tanaka Y., Ishikawa F., Kuwabara T., Kondo M.
    • Organizer
      第42回 日本免疫学会総会学術集会
    • Place of Presentation
      千葉県 千葉市 幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] SATB1 is necessary for IEL development.2013

    • Author(s)
      Guo x., Tanaka Y., Kondo M.
    • Organizer
      第42回 日本免疫学会総会学術集会
    • Place of Presentation
      千葉県 千葉市 幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Acetylation modulates interleukin-2 receptor signaling.2013

    • Author(s)
      Kuwabara T., Kondo M.
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] SATB1 is necessary for establishment of the immune tolerance2012

    • Author(s)
      田中 ゆり子
    • Organizer
      第41回 日本免疫学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-12-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genome organizer SATB1 is critical for T cell maturation in the thymus

    • Author(s)
      Tanaka Y., Guo X., Mukozu T., Kuwabara T., Kondo M.
    • Organizer
      第42回 日本免疫学会総会学術集会
    • Place of Presentation
      千葉県 千葉市 幕張メッセ
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi