An epidemiological study regarding cause-specific death among dialysis patients before and after the great east Japan earthquake

• Project/Area Number: 24390155
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Iwate Medical University
• Principal Investigator: OOSAWA MASAKI 岩手医科大学, 医学部, 非常勤講師 (60295970)
• Co-Investigator(Renkei-kenkyūsha): FUJIOKA TOMOAKI 岩手医科大学, 医学部, 名誉教授 (80173409) ; TANNO KOZO 岩手医科大学, 医学部, 准教授 (20327026) ; ONODA TOSHIYUKI 岩手医科大学, 医学部, 客員教授 (00254748) ; OKAYAMA AKIRA 日本大学, 医学部, 専任講師 (60169159) ; MAKITA SHINJI 岩手医科大学, 医学部, 准教授 (60306024) ; ISHIBASHI YASUHIRO 岩手医科大学, 医学部, 講師 (40405741) ; OOMAMA SHINICHI 岩手医科大学, 医学部, 講師 (20453300)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 透析患者 / 震災 / 死亡率 / 疫学 / 末期腎不全 / 透析治療

Outline of Final Research Achievements

Risk of death in dialysis patients is thought to be increased after the great east Japan earthquake (March 11th 2011). We estimated crude mortality rates in dialysis patients before and after the disaster (2010, 2011 and 2012) in the Iwate Prefecture. The mortality rate during the first 30 days after the disaster (from March 11th to April 10th) was 198.6（per 1000 person-years）and the rate was 2-fold higher than the rates of other periods (90~112 per 1000 person-years). Number of deaths on March 11th 2011 was 16. After excluding the 16 dead cases, mortality rate during the first 29 days (from March 12th to April 10th) was 137.1 and still higher than the rates of other periods. Increased number of cardiovascular death in inland area might contribute to the increased mortality after the disaster in the whole area of Iwate Prefecture as well as the contribution of death due to disaster in seacoast area.

Research Products

• [Journal Article] The Iwate KENCO Study:Design and Rationale (2016)
  • Author(s): 大澤正樹、岡山明
  • Journal Title: 呼吸と循環 Volume: 64 Issue: 1 Pages: 37-48
  • DOI: 10.11477/mf.1404205881
  • ISSN: 0452-3458, 1882-1200
  • Year and Date: 2016-01-15
  • Peer Reviewed
• [Journal Article] Standardized Prevalence Ratios for Atrial Fibrillation in Adult Dialysis Patients in Japan (2016)
  • Author(s): Ohsawa M, Tanno K,Okamura1 T,Yonekura Y,Kato K,Fujishima Y,Obara W,Abe T, Itai K, Ogasawara K,Omama S,Turin TC, Miyamatsu N,Ishibashi Y, Yoshihiro M, Itoh T,Onoda T,Kuribayashi T, Makita S,Yoshida Y,Nakamura M,Tanaka F,Ohta M,Sakata K,Okayama A
  • Journal Title: Journal of Epidemiology Volume: 26 Issue: 5 Pages: 272-276
  • DOI: 10.2188/jea.JE20150077
  • NAID: 130005150469
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Low-grade albuminuria and incidence of cardiovascular disease and all-cause mortality in nondiabetic and normotensive individuals (2016)
  • Author(s): Tanaka F, Komi R, Makita S, Onoda T, Tanno K, Ohsawa M, Itai K, Sakata K, Omama S, Yoshida Y, Ogasawara K, Ishibashi Y, Kuribayashi T, Okayama A, Nakamura M
  • Journal Title: Journal of Hypertension Volume: 34 Issue: 3 Pages: 506-512
  • DOI: 10.1097/hjh.0000000000000809
  • Peer Reviewed / Open Access
• [Journal Article] Renal function trajectory over time and adverse clinical outcomes. (2016)
  • Author(s): Sohel BM, Rumana N, Ohsawa M, Turin TC, Kelly MA, Al Mamun M.
  • Journal Title: Clinical and experimental nephrology Volume: in press Issue: 3 Pages: 379-393
  • DOI: 10.1007/s10157-015-1213-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Relative and absolute risks of all-cause and cause-specific deaths attributable to atrial fibrillation in middle-aged and elderly community dwellers (2015)
  • Author(s): Ohsawa M, Okamura T, Ogasawara K, Ogawa A, Fujioka T, .Yonekura Y, Omama S, Turin TC, Itai K, Ishibashi Y, Morino Y. Itoh T, Miyamatsu N, Onoda T,. Kuribayashi T, Makita S,. Yoshida Y, Nakamura M, Tanaka F, Ohta M, Sakata K, Okayama AA.
  • Journal Title: International Journal of Cardiology Volume: 184 Pages: 692-698
  • DOI: 10.1016/j.ijcard.2015.03.068
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Elevated blood pressure at the first measurement predicts cardiovascular disease independently from the subsequent second reading in men, but not in women. (2014)
  • Author(s): Makita S, Tanaka F, Onoda T, Ohsawa M, Tanno K, Omama S, Yoshida Y, Ishibashi Y, Segawa T, Takahashi T, Satoh K, Itai K, Sakata K, Ohta M, Kuribayashi T, Ogasawara K, Ogawa A, Okayama A, Nakamura M.
  • Journal Title: Clin Exp Hypertens Volume: in press Issue: 1 Pages: 39-44
  • DOI: 10.3109/10641963.2014.897720
  • Peer Reviewed
• [Journal Article] Tightrope walking: Achieving the best possible balance between better model fit and accurate prediction: Response to letter (IJC-D-14-00417). (2014)
  • Author(s): Ohsawa M, Ogasawara K, Okayama A.
  • Journal Title: Int J Cardiol Volume: 174 Issue: 3 Pages: 791-794
  • DOI: 10.1016/j.ijcard.2014.04.124
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cardiovascular risk stratification with plasma B-type natriuretic peptide levels in a community-based hypertensive cohort. (2014)
  • Author(s): Sato K, Segawa T, Tanaka F, Takahashi T, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Omama S, Ogasawara K, Ishibashi Y, Makita S, Okayama A, Nakamura M.
  • Journal Title: Am J Cardiol. Volume: 113(4) Issue: 4 Pages: 682-6
  • DOI: 10.1016/j.amjcard.2013.11.012
  • Peer Reviewed
• [Journal Article] Associations of number of teeth with risks for all-cause mortality and cause-specific mortality in middle-aged and elderly men in the northern part of Japan: the Iwate-KENCO study. (2014)
  • Author(s): Ando A, Tanno K, Ohsawa M, Onoda T, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ishibashi Y, Kuribayashi T, Koyama T, Itai K, Ogawa A, and Okayama A.
  • Journal Title: Community Dent Oral Epidemiol Volume: 印刷中 Issue: 4 Pages: 358-65
  • DOI: 10.1111/cdoe.12095
  • Peer Reviewed
• [Journal Article] Comparison of predictability of future cardiovascular events between chronic kidney disease (CKD) stage based on CKD epidemiology collaboration equation and that based on modification of diet in renal disease equation in the Japanese general population--Iwate KENCO Study (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Turin TC, Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama SI, Ishibashi Y, Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, Okayama A.
  • Journal Title: Circ J Volume: 77 Pages: 1315-1325
  • NAID: 10031151396
  • Peer Reviewed
• [Journal Article] Concordance of CKD stages in estimation by the CKD-EPI equation and estimation by the MDRD equation in the Japanese general population: the Iwate KENCO Study. (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Turin TC, Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y, Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, and Okayama A.
  • Journal Title: Int J Cardiol Volume: 165(2) Issue: 2 Pages: 377-379
  • DOI: 10.1016/j.ijcard.2012.08.025
  • Peer Reviewed
• [Journal Article] High risks of all-cause and cardiovascular deaths in apparently healthy middle-aged people with preserved glomerular filtration rate and albuminuria: A prospective cohort study. (2013)
  • Author(s): Ohsawa M, Fujioka T, Ogasawara K, Tanno K, Okamura T, Turin TC, Itai K, Ogawa A, Yoshida Y, Omama S, Onoda T, Nakamura M, Makita S, Ishibashi Y, Tanaka F, Kuribayashi T, Ohta M, Sakata K, and Okayama A.
  • Journal Title: Int J Cardiol. Volume: 170(2) Issue: 2 Pages: 167-172
  • DOI: 10.1016/j.ijcard.2013.10.076
  • Peer Reviewed
• [Journal Article] Incidence rate of cerebrovascular diseases in northern Japan determined from the Iwate Stroke Registry with an inventory survey system. (2013)
  • Author(s): Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Ohsawa M, Tanno K, Onoda T, Itai K, Sakata K, Okayama A.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 22(8) Issue: 8 Pages: e317-e322
  • DOI: 10.1016/j.jstrokecerebrovasdis.2012.12.011
  • Peer Reviewed
• [Journal Article] Factors Related to Tooth Loss Among Community-Dwelling Middle-aged and Elderly Japanese Men. (2013)
  • Author(s): Ando A, Ohsawa M, Yaegashi Y, Sakata K, Tanno K, Onoda T, Itai K, Tanaka F, Makita S, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, Okayama A,
  • Journal Title: J Epidemiol Volume: 23 Pages: 301-306
  • NAID: 10031183197
  • Peer Reviewed
• [Journal Article] Influence of the great East Japan earthquake and tsunami 2011 on occurrence of cerebrovascular diseases in Iwate, Japan. (2013)
  • Author(s): Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Nakamura M, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K
  • Journal Title: Stroke Volume: 44 Pages: 1518-1524
  • Peer Reviewed
• [Journal Article] Predictive Value of Lipoprotein Indices for Residual Risk of Acute Myocardial Infarction and Sudden Death in Men With Low-Density Lipoprotein Cholesterol Levels <120 mg/dl. (2013)
  • Author(s): Tanaka F, Makita S, Onoda T, Tanno K, Ohsawa M, Itai K, Sakata K, Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Okayama A, Nakamura M,
  • Journal Title: Am J Cardiol Volume: 112 Pages: 1063-1068
  • Peer Reviewed
• [Journal Article] Plasma B-type natriuretic peptide as a predictor of cardiovascular events in subjects with atrial fibrillation: a community-based study. (2013)
  • Author(s): Nakamura M, Koeda Y, Tanaka F, Onoda T, Itai K, Ohsawa M, Tanno K, Sakata K, Omama S, Ishibashi Y, Makita S, Ohta M, Ogasawara K, Komatsu T, Okayama A.
  • Journal Title: PLoS One. Volume: 8(12) Issue: 12 Pages: e81243-e81243
  • DOI: 10.1371/journal.pone.0081243
  • Peer Reviewed
• [Journal Article] Conflicting effect of alcohol on cardiovascular risk: a clue to understand the different etiologies of coronary artery disease, stroke and peripheral artery disease (2013)
  • Author(s): 大澤正樹
  • Journal Title: Hypertens Res. 2013 Jan;36(1):16-8. Volume: 36 Issue: 1 Pages: 16-18
  • DOI: 10.1038/hr.2012.152
  • Peer Reviewed
• [Journal Article] Comparison of Predictability of Future Cardiovascular Events Between Chronic Kidney Disease (CKD) Stage Based on CKD Epidemiology Collaboration Equation and That Based on Modification of Diet in Renal Disease Equation in the Japanese General Population. (2013)
  • Author(s): Ohsawa M
  • Journal Title: Circ J Volume: 77 Pages: 1315-1325
  • Peer Reviewed
• [Journal Article] Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population. (2013)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, and Okayama A.
  • Journal Title: J Psychosom Res Volume: 73(3) Issue: 3 Pages: 225-231
  • DOI: 10.1016/j.jpsychores.2012.05.013
  • Peer Reviewed
• [Journal Article] 血液透析患者の死因と突然死に関する疫学研究 (2012)
  • Author(s): 大澤正樹
  • Journal Title: 日本循環器病予防学会誌 Volume: 47 Pages: 120-138
  • Peer Reviewed
• [Journal Article] Plasma B-type natriuretic peptide is useful for cardiovascular risk assessment in community-based diabetes subjects : comparison with albuminuria. (2012)
  • Author(s): Onodera M
  • Journal Title: Int Heart J Volume: 53 Pages: 176-181
  • Peer Reviewed
• [Presentation] Burdens of Atrial fibrillation (2015)
  • Author(s): Ohsawa M
  • Organizer: 2015 8th Asia Pacific Heart Rhythm Sociaty SCIENTIC SESSIONS
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2015-11-20
  • Int'l Joint Research / Invited
• [Presentation] Risk grading by CHA2DS2_Vasc score is useful in non-dialysis subjects with atrial fibrillation while it is not useful in Dialysis patients because of their very high CHA2DS2_Vasc scores. (2015)
  • Author(s): Ohsawa M, Okayama A, Tanno K, Okamura T,Yonekura Y, Obara W, Abe T, Ohmori S, Itai K, Konishi K, Kato K, Fujishima Y, Ogasawara K, Nakamura M, Moriono Y, Itoh T, Onoda T, Yoshida Y, Sakata K, Omama S, Ishibashi Y, Makita S, Tanaka F, Kuribayashi T, Ohta M, Fujioka T
  • Organizer: American Sodietyt Nephrology Annual Meeting Kidney Week 2015
  • Place of Presentation: San Diego, CA
  • Year and Date: 2015-11-06
  • Int'l Joint Research
• [Presentation] 高齢者の喫煙状況と死因別死亡リスクの検討―岩手県北地域コホート研究の結果 (2015)
  • Author(s): 栗林徹、大澤正樹、丹野高三、米倉佑貴、小笠原邦明、板井一好、中村元行、小野田敏行、大間々真一、吉田雄樹、石橋靖宏、蒔田真司、田中文隆、坂田清美、太田睦子、岡山明
  • Organizer: 第74回日本公衆衛生学会総会
  • Place of Presentation: 長崎市
  • Year and Date: 2015-11-05
• [Presentation] 慢性腎臓病が死亡・心筋梗塞発症・脳卒中発症・末期腎不全発症に与える影響について―岩手県北コホート研究5年間の前向き調査結果 (2015)
  • Author(s): 大澤正樹、藤岡知昭、岩動孝、小原航、大森聡、小笠原邦昭、丹野高三、米倉佑貴、大間々真一、中村元行、石橋靖宏、小野田敏行、蒔田真司、栗林徹 、坂田清美、田中文隆 、太田睦子、岡山明
  • Organizer: 第51回日本循環器病予防学会
  • Place of Presentation: 大阪大学中之島センター
  • Year and Date: 2015-06-27
• [Presentation] Smoking Contributes to an Increased Risk and Cessation of Smoking Contributes to a Decreased Risk of Stroke Among Elderly Men. (2015)
  • Author(s): Ohsawa M, Kuribayashi T, Tanno K, Yonekura Y, Itai K, Onoda T, Ogawa A, Ogasawara K, Omama S, Yosida Y, Nakamura M, Ishibashi Y, Makita S, Tanaka F, Sakata K, Okayama A.
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-04-26
• [Presentation] The crude annual mortality rate of patients with End Stage Renal Disease slightly decreased and the crude incidence rate of End Stage Renal Disease continued to increase in the disaster area in the following year of The Great East Japan Earthquake 2011. (2014)
  • Author(s): Masaki Ohsawa, So Ohmori, Wataru Obara, Takashi Isurugi*, Kozo Tanno, Toshiyuki Onoda, Shinichi Omama, Yasuhiro Ishibashi, Shinji Makita, Akira Okayama, Tomoaki Fujioka
  • Organizer: 2014 Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2014-11-15
• [Presentation] 東日本大震災津波被災地域における透析患者新規導入者数の変化第二報 (2014)
  • Author(s): 大澤正樹、大森 聡、岩動 孝、丹野高三、小野田敏行、大間々真一、石橋靖宏、蒔田真司、岡山 明、藤岡知昭、
  • Organizer: 第73回日本公衆衛生学会総会
  • Place of Presentation: 栃木県宇都宮市
  • Year and Date: 2014-11-05
• [Presentation] 災津波被災地域における末期腎不全患者の死亡率の変化に関する研究― 岩手県末期腎不全登録事業による集計結果 第2報 (2014)
  • Author(s): 大澤正樹、藤岡知昭、大森聡 、岩動孝*、丹野高三、大間々真一、石橋靖弘、蒔田真司、小野田敏行、岡山明
  • Organizer: 第50回日本循環器病予防学会
  • Place of Presentation: 京都市
  • Year and Date: 2014-07-20
• [Presentation] Both Higher And Lower Estimated Glomerular Filtration Rates Are Associated With Higher Risks of All-cause Death And Cardiovascular Mortality And Morbidity Among Elderly Japanese People (2013)
  • Author(s): Ohsawa M
  • Organizer: 53th AHA Cardiovascular Disease Epidemiology and Prevention Annual Conference
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2013-03-21
• [Presentation] Reduced and Higher Estimated Glomerular Filtration Rates are Associated with Increased Risks of All-cause and Cardiovascular Death among Japanese People. (2013)
  • Author(s): Ohsawa M
  • Organizer: The 77th Annual Scientific Meetings of the Japanese Circulation Society
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2013-03-17
• [Presentation] Hemodialysis patients with atrial fibrillation have a 1.7-fold higher risk for all-cause death despite of lacking the elevated risks for cardiovascular mortality (2012)
  • Author(s): Ohsawa M
  • Organizer: 2012 Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, CA
  • Year and Date: 2012-11-01
• [Presentation] Lipid profile and risks for cardiovascular mortality and morbidity in Japanese hemodialysis patients (2012)
  • Author(s): Ohsawa M
  • Organizer: 80th European Atherosclerosis Society Congress
  • Place of Presentation: Milan, Italy
• [Presentation] 東日本大震災津波被災地域における透析患者新規導入者数の変化
  • Author(s): 大澤正樹、大森 聡、岩動 孝、丹野高三、小野田敏行、大間々真一、石橋靖宏5、蒔田真司、岡山 明、藤岡知昭
  • Organizer: 第72回日本公衆衛生学会総会
  • Place of Presentation: 三重県津市
• [Presentation] Changes in mortality rates among patients with end-stage renal disease (ESRD) and changes in incident rates of ESRD after the Great East Japan Earthquake and Tsunami in 2011
  • Author(s): Ohsawa M
  • Organizer: 2013 Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Atlanta, GA
• [Presentation] A HIGHER SERUM ARSENIC LEVEL IS ASSOCIATED WITH A HIGHER RISK FOR INCIDENT MYOCARDIAL INFARCTION IN HEMODIALYSIS PATIENTS
  • Author(s): Ohsawa M, Tanno K, Itai K, Fujishima Y, Kato K, Onoda T, Sakata K, Okayama A, Fujioka T
  • Organizer: 81th European Atherosclerosis Society Congress
  • Place of Presentation: Lyon, France
• [Presentation] 東日本大震災津波被災地域における末期腎不全患者の死亡率の変化に関する研究―岩手県末期腎不全登録事業よる集計結果
  • Author(s): 大澤正樹、藤岡知昭、大森 聡 、岩動 孝、丹野高三、大間々真一、石橋靖弘、蒔田真司、小野田敏行、岡山 明
  • Organizer: 第48回日本循環器病予防学会
  • Place of Presentation: Lyon France
• [Remarks] 岩手県北地域コホート研究
  • URL: http://iwate-kenco.jp/
• [Remarks] 循環器疫学サイト 岩手県北地域コホート
  • URL: http://www.epi-c.jp/