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Prevention of non-communicable diseases and metabolic profiling in a population-based cohort study

Research Project

Project/Area Number 24390168
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionKeio University

Principal Investigator

TAKEBAYASHI Toru  慶應義塾大学, 医学部, 教授 (30265780)

Co-Investigator(Kenkyū-buntansha) OKAMURA Tomonori  慶應義塾大学, 医学部, 教授 (00324567)
NISHIWAKI Yuji  東邦大学, 医学部, 教授 (40237764)
SOGA Tomoyoshi  慶應義塾大学, 環境情報学部, 教授 (60338217)
Co-Investigator(Renkei-kenkyūsha) TOMITA Masaru  慶應義塾大学, 環境情報学部, 教授 (60227626)
AKIYAMA Miki  慶應義塾大学, 環境情報学部, 准教授 (50439254)
MIYAMOTO Yoshihiro  独立行政法人国立循環器病研究センター, 予防検診部, 部長 (10312224)
SUGIMOTO Masahiro  慶應義塾大学, 政策メディア研究科, 特任准教授 (30458963)
MIURA Katsuyuki  滋賀医科大学, 医学部, 教授 (90257452)
UESHIMA Hirotsugu  滋賀医科大学, 学内共同利用施設等, 特任教授 (70144483)
ASAKURA Keiko  東京大学, 情報学環, 助教 (40306709)
Research Collaborator KURIHARA Ayako  慶應義塾大学, 医学部, 助教
HARADA Sei  慶應義塾大学, 医学部, 助教
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywordsメタボローム / コホート / バイオマーカー / 飲酒 / 身体活動 / 疫学 / メタボローム解析 / コホート研究 / 生活習慣
Outline of Final Research Achievements

CE/MS-based metabolome profiling was applied to a population-based epidemiologic study. Stable analytical procedures was first established, and then relationships between plasma metabolic profiling and lifestyle factors were examined in men. 27 metabolites were significantly related to alcohol drinking, and 6 were associated with total physical activity. Data set for 3 cohorts from different regions was completed. Further study is planned for follow-up and replication analysis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) Remarks (3 results)

  • [Journal Article] Comparison of charged metabolomic profiles in serum and plasma and their processing and storage conditions2015

    • Author(s)
      Hirayama A, Sugimoto M, Suzuki A, Hatakeyama Y, Enomoto A, Harada S, Kurihara A, Soga T, Tomita M, Takebayashi T
    • Journal Title

      Electrophoresis

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] メタボローム解析の疫学研究への応用とその展望2014

    • Author(s)
      武林亨
    • Journal Title

      医学のあゆみ

      Volume: 249 Pages: 329-332

    • Related Report
      2014 Annual Research Report
  • [Journal Article] メタボローム2014

    • Author(s)
      武林亨
    • Journal Title

      動脈硬化予防

      Volume: 12 Pages: 71-73

    • Related Report
      2013 Annual Research Report
  • [Presentation] Metabolomic pathway analysis in a large population study reveals metabolic change by alcohol intake and hypertension2015

    • Author(s)
      Harada S, Takebayashi T, et al.
    • Organizer
      第25回日本疫学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-01-21 – 2015-01-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Accumulation of metabolic syndrome risk factors and plasma amino acids and their related metabolites: Tsuruoka Metabolomic Cohort Study2014

    • Author(s)
      Takebayashi T, et al.
    • Organizer
      10th Annual Meeting of Metabolomics Society
    • Place of Presentation
      Tsuruoka
    • Year and Date
      2014-06-23 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Metabolomic profiling reveals novel biomarkers of alcohol-induced hypertension in community-dwelling men: Tsuruoka metabolomic study2014

    • Author(s)
      Harada S, Takebayashi T, et al
    • Organizer
      10th Annual Meeting of Metabolomics Society
    • Place of Presentation
      Tsuruoka
    • Year and Date
      2014-06-23 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高血圧に関連する血漿中メタボロームプロファイルの検討:鶴岡メタボロームコホート研究2014

    • Author(s)
      横山葉子
    • Organizer
      第24回日本疫学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] メタボロームワイドアソシエーション研究による習慣的飲酒に起因する肝機能障害のバイオマーカー探索:鶴岡メタボロームコホート研究2014

    • Author(s)
      原田成
    • Organizer
      第24回日本疫学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域在住者におけるメタボリック症候群要因の集積と血漿中アミノ酸の関連:鶴岡メタボロームコホート研究2014

    • Author(s)
      武林亨
    • Organizer
      第24回日本疫学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域在住者の血漿中メタボロームと飲酒量の関連(鶴岡メタボロームコホート研究)2013

    • Author(s)
      原田成, ほか
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] メタボローム解析を疫学研究に導入するための基礎的検討(鶴岡メタボロームコホート研究)2013

    • Author(s)
      武林亨, ほか
    • Organizer
      第23回日本疫学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2013-01-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 地域在住者の血漿中メタボロームプロファイルの検討(鶴岡メタボロームコホート研究ベースライン調査)2013

    • Author(s)
      原田成, ほか
    • Organizer
      第23回日本疫学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2013-01-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Application of metabolomic analysis to a population-based, prospective cohort study: Design and sample preparation method Tsuruoka metabolomic cohort study2013

    • Author(s)
      Takebayashi T
    • Organizer
      9th Annual Conference of the Metabolomics Society
    • Place of Presentation
      Glasgow
    • Related Report
      2013 Annual Research Report
  • [Presentation] Plasma metabolomic profiling in community-dwelling adults: Metabolites related to alcohol intake and liver diseases Tsuruoka Metabolomic Cohort Study2013

    • Author(s)
      Harada S
    • Organizer
      9th Annual Conference of the Metabolomics Society
    • Place of Presentation
      Glasgow
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域在住者の栄養摂取量と血漿中アミノ酸濃度の関連 (鶴岡メタボロームコホート研究)2013

    • Author(s)
      栗原綾子
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域在住者を対象とした鶴岡メタボロームコホート研究-デザインならびに初年度4ヶ月間の参加者プロファイル-2012

    • Author(s)
      武林亨, ほか
    • Organizer
      第7回メタボロームシンポジウム
    • Place of Presentation
      山形県鶴岡市
    • Year and Date
      2012-10-10
    • Related Report
      2012 Annual Research Report
  • [Remarks] 鶴岡みらい健康調査

    • URL

      http://tsuruoka-mirai.net/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 鶴岡みらい健康調査

    • URL

      http://tsuruoka-mirai.net/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://tsuruoka-mirai.net/

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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