Investigation into functional mechanisms of herbal medicines with attention to sex hormonal effects - towards the development of anti-ageing drugs -
| Project/Area Number |
24390180
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ETO Masato 東京大学, 医学部附属病院, 特任准教授 (80282630)
OGAWA Sumito 東京大学, 医学部附属病院, 准教授 (20323579)
OTA Hidetaka 東京大学, 医学部附属病院, 特任講師 (20431869)
OGABE Tetsuro 東京大学, 医学部附属病院, 特任准教授 (80169135)
YU Sei 東京大学, 医学部附属病院, 特任助教 (40431845)
SHIBAJAKI Kouji 東京大学, 医学部附属病院, 特任臨床医 (20625735)
孫 輔卿 東京大学, 高齢社会総合研究機構, 助教 (20625256)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 東洋医学 / エストロゲン / アンドロゲン / 老化 |
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| Outline of Final Research Achievements |
In the present study, for a comprehensive understanding and classification of Kampo, we used components of Kampo with sex hormone-like actions and examined their effects on various tissues including vessel, neuron and cancer. In breast cancer cells, one component had proliferative actions like estrogen, whereas the others did not. All of components did not have proliferative actions, whereas testosterone had in prostate cancer cells. Furthermore, in vessel, calcification of smooth muscle cells were inhibited by all of components and this inhibition was also seen by both estrogen and testosterone. In neuronal cells, ginsenoside Rb1, especially had protective effects on apoptosis-induced cell damage. With these results, exploitation of novel medicine as a substitute of hormone replacement could be expected.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies.2014
Author(s)
Brand JS, Rovers MM, Yeap BB, Schneider HJ, Tuomainen TP, Haring R, Corona G, Onat A, Maggio M, Bouchard C, Tong PC, Chen RY, Akishita M,et al.
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Journal Title
PLoS One
Volume: 9
Issue: 7
Pages: e100409-e100409
DOI
Related Report
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