Elucidation of spiral interactions of virus and inflammation in hepatitis C-associated hepatocarcinogenesis as revealed by microRNA analysis
| Project/Area Number |
24390183
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
KOIKE KAZUHIKO 東京大学, 医学部附属病院, 教授 (80240703)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORIYA Kyoji 東京大学, 医学部附属病院, 教授 (00272550)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
|---|
| Keywords | 肝癌 / 肝炎ウイルス / 炎症 / 遺伝子変異 |
|---|
| Outline of Final Research Achievements |
To determine the roles of viral proteins and inflammation in hepatocarcinogenesis, the HCV core gene transgenic mice were mated with ①liver-specific AID-KO mice, and ②liver-specific activation-induced cytidine deaminase (AID) Tg mice. In HCV-Tg/AID-/- mice, the incidence of HCC was not different from that in HCV-Tg/AID+/+ mice, showing that AID does not play a central role in HCV-associated hepatocarcinogenesis. On the other hand, in HCV-Tg/AID+++/+++ mice, 90% of those mice developed HCC, showing a synergy of inflammation-induced genetic aberrations and the viral oncoprotein in hepatocarcinogenesis.
|
Report
(4 results)
Research Products
(27 results)
-
[Journal Article] Sarcopenia, Intramuscular Fat Deposition, and Visceral Adiposity Independently Predict the Outcomes of Hepatocellular Carcinoma2015
Author(s)
Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, Nakagomi R, Kondo M, Nakatsuka T, Minami T, Sato M, Uchino K, Enooku K, Kondo Y, Asaoka Y, Tanaka Y, Ohtomo K, Shiina S, Koike K
-
Journal Title
J Hepatol.
Volume: 62
Pages: 131-140
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Mitochondrial iron accumulation exacerbates hepatic toxicity caused by hepatitis C virus core protein2015
Author(s)
Sekine S, Ito K, Watanabe H, Nakano T, Moriya K, Shintani Y, Fujie H, Tsutsumi T, Miyoshi H, Fujinaga H, Shinzawa S, Koike K, Horie T.
-
Journal Title
Toxicol Appl Pharmacol.
Volume: 282
Pages: 237-243
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models.2014
Author(s)
Nguyen T, Xu J, Chikuma S, Hiai H, Kinoshita K, Moriya K, Koike K, Marcuzzi GP, Pfister H, Honjo T, Kobayashi M.
-
Journal Title
Int. Immunol.
Volume: 26
Pages: 397-406
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development2014
Author(s)
Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M.
-
Journal Title
Cancer Cell
Volume: 26
Pages: 331-343
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles2014
Author(s)
Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y
-
Journal Title
PLoS Pathogen
Volume: 10(12)
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.2014
Author(s)
Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Kojima S, Matsuura T, Koike K, Yatomi Y, Ikeda H.
-
Journal Title
Int J Cancer
Volume: 134
Pages: 2189-2198
DOI
Related Report
Peer Reviewed
-
[Journal Article] Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.2014
Author(s)
Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S.
-
Journal Title
Proc Natl Acad Sci USA
Volume: 111
Pages: 1090-1090
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Fluvastatin Ameliorates Liver Desease in HCV Mouse Model with Improvements of Lipid Metabolism, Mitochondrial Dysfunction and Intrahepatic Cardiolipin Composition.
Author(s)
Hidetaka Fujinaga ,Seiko Shinzawa,Junken Aoki,Kazuya Okushin,Kohji Goto,Hideyuki Miyoshi,Takeya Tsutsumi,Yoshizumi Shintani,Hiroshi Yotsuyanagi,Kyoji Moriya,Kazuhiko Koike
Organizer
48th Annual Meeting of the European Association for the Study of the Liver
Place of Presentation
Amsterdam RAI
Related Report
-
-
