Development of biomarkers using cancer cells derived from clinical samples
Project/Area Number |
24390188
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Osaka University |
Principal Investigator |
TSUJII Masahiko 大阪大学, 医学(系)研究科(研究院), 准教授 (40303937)
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Co-Investigator(Kenkyū-buntansha) |
TAKEHARA Tetsuo 大阪大学, 大学院医学系研究科, 教授 (70335355)
HAYASHI Yoshito 大阪大学, 医学部附属病院, 助教 (80647123)
IIJIMA Hideki 大阪大学, 大学院医学系研究科, 講師 (90444520)
近藤 純平 大阪大学, 医学系研究科, 医員 (80624593)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | 大腸癌 / 化学療法 / 分子標的治療 / オーダーメード医療 / 個別化医療 / 単離培養 / 薬剤感受性 / スクリーニング / 薬剤耐性 / CTOS / バイオマーカー / 抗癌剤感受性 / 抗癌剤耐性 / 分子標的治療薬 |
Outline of Final Research Achievements |
Nineteen CTOS were isolated and cultured from 20 colorectal cancer cases of which chemosensitivities were confirmed on clinical course at the date of February 17, 2015. Regarding sensitivity to chemotherapy or molecular target drugs, it was confirmed that in vitro variability detected between individual CTOS coincided with individual difference of subcutaneously implanted CTOS. In a colon cancer case where the growth of liver metastasis was inhibited by XELOX and Bevacizumab, it was shown that the CTOSs derived from primary colon cancer tissue were chemosensitive to 5-FU and SN-38 in vitro culturing system. Even in the worst case of failure of the present XELOX therapy, it is deduced that irinotecan hold promise for treating and its effect is planning to be investigated.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS.2015
Author(s)
sujii Y, Kato M, Inoue T, Yoshii S, Nagai K, Fujinaga T, Maekawa A, Hayashi Y, Akasaka T, Shinzaki S, Watabe K, Nishida T, Iijima H, Tsujii M, Takehara T.
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Journal Title
Gastrointest Endosc.
Volume: 15
Issue: 3
Pages: 452-459
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms: a multicenter retrospective cohort study.2015
Author(s)
Tsujii Y, Nishida T, Nishiyama O, Yamamoto K, Kawai N, Yamaguchi S, Yamada T, Yoshio T, Kitamura S, Nakamura T, Nishihara A, Ogiyama H, Nakahara M, Komori M, Kato M, Hayashi Y, Shinzaki S, Iijima H, Michida T, Tsujii M, Takehara T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Chemoradiotherapy is effective for primary esophageal adenosquamous cell carcinoma but ineffective for the metastatic adenocarcinoma component2015
Author(s)
Nozaki Y, Nishida T, Hori Y, Shinzaki S, Kato M, Yakushijin T, Iijima H, Tsujii M, Morii E, Takehara T.
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Journal Title
Nippon Shokakibyo Gakkai Zasshi
Volume: 112
Issue: 2
Pages: 278-286
DOI
NAID
ISSN
0446-6586, 1349-7693
Related Report
Peer Reviewed
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[Journal Article] The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells.2015
Author(s)
Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E, Inoue T, Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
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Journal Title
Int J Oncol.
Volume: 46
Issue: 4
Pages: 1151-1159
DOI
Related Report
Peer Reviewed
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[Journal Article] Gastric endoscopic submucosal dissection under steady pressure automatically controlled endoscopy (SPACE); a multicenter randomized preclinical trial.2015
Author(s)
Yamada T, Hirota M, Tsutsui S, Kato M, Takahashi T, Yasuda K, Sumiyama K, Tsujii M, Takehara T, Mori M, Doki Y, Nakajima K.
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Journal Title
Surg Endosc.
Volume: ahead
Related Report
Peer Reviewed
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[Journal Article] 5FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.2015
Author(s)
Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T, Yamamoto S, Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S, Inoue T, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
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Journal Title
Int J Oncol.
Volume: 46
Issue: 1
Pages: 63-70
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.2014
Author(s)
Mukai A, Iijima H, Hiyama S, Fujii H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Hayashi Y, Kondo J, Mizushima T, Kanto T, Egawa S, Nishida T, Tsujii M, Takehara T.
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Journal Title
J Gastroenterol.
Volume: 49
Issue: 12
Pages: 1524-1535
DOI
Related Report
Peer Reviewed
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[Journal Article] Atypical duodenal ulcer and invagination caused by a large pedunculated duodenal Brunner's gland hamartoma.2014
Author(s)
Nakabori T, Shinzaki S, Yamada T, Nishida T, Iijima H, Tsujii M, Kurokawa Y, Mori M, Doki Y, Morii E, Takehara T.
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Journal Title
Gastrointest Endosc.
Volume: 79
Issue: 4
Pages: 679-680
DOI
Related Report
Peer Reviewed
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[Journal Article] Lymph node enlargement after definitive chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma.2014
Author(s)
Hayashi Y, Nishida T, Tsujii M, Tsutsui S, Yamamoto K, Isohashi F, Yamasaki M, Miyata H, Kato M, Yamada T, Shinzaki S, Iijima H, Ogawa K, Doki Y, Takehara T.
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Journal Title
BMC Cancer.
Volume: 14
Issue: 1
Pages: 706-706
DOI
Related Report
Peer Reviewed
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[Journal Article] Esophageal adenocarcinoma with white opaque substance observed by magnifying endoscopy with narrow band imaging.2014
Author(s)
Yoshii S, Kato M, Honma K, Fujinaga T, Tsujii Y, Maekawa A, Inoue T, Hayashi Y, Akasaka T, Shinzaki S, Nishida T, Iijima H, Tsujii M, Morii E, Takehara T.
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Journal Title
Dig Endosc.
Volume: 27
Issue: 3
Pages: 392-396
DOI
Related Report
Peer Reviewed
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[Journal Article] Esophageal submucosal dissection under steady pressure automatically controlled endoscopy (SPACE): a clinical feasibility study.2014
Author(s)
Kato M, Nakajima K, Yamada T, Hirota M, Miyazaki Y, Yamasaki M, Nishida T, Mori M, Doki Y, Tsujii M, Takehara T.
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Journal Title
Endoscopy.
Volume: 46
Issue: 08
Pages: 680-684
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan.2014
Author(s)
Nishida T, Tsujii M, Tanimura H, Tsutsui S, Tsuji S, Takeda A, Inoue A, Fukui H, Yoshio T, Kishida O, Ogawa H, Oshita M, Kobayashi I, Zushi S, Ichiba M, Uenoyama N, Yasunaga Y, Ishihara R, Yura M, Komori M, Egawa S, Iijima H, Takehara T.
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Journal Title
World J Gastroenterol.
Volume: 20
Issue: 15
Pages: 4362-4369
DOI
Related Report
Peer Reviewed
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[Journal Article] Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice.2014
Author(s)
Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T.
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Journal Title
Inflamm Bowel Dis.
Volume: 5
Issue: 5
Pages: 790-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical features of post-polypectomy bleeding associated with heparin bridge therapy.2014
Author(s)
Inoue T, Nishida T, Maekawa A, Tsujii Y, Akasaka T, Kato M, Hayashi Y, Yamamoto S, Kondo J, Yamada T, Shinzaki S, Iijima H, Tsujii M, Takehara T.
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Journal Title
Dig Endosc.
Volume: 26
Issue: 2
Pages: 243-249
DOI
Related Report
Peer Reviewed
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[Journal Article] Amelioration of Small Bowel Injury by Switching from Nonselective Nonsteroidal Anti-Inflammatory Drugs to Celecoxib in Rheumatoid Arthritis Patients: A Pilot Study2013
Author(s)
Inoue, T., Iijima, H., Arimitsu, J., Hagihara, K., Kawai, S., Shiraishi, E., Hiyama, S., Mukai, A., Shinzaki, S., Nishida, T., Ogata, A., Tsujii, M., Takehara, T.
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Journal Title
Digestion
Volume: 89
Issue: 2
Pages: 124-132
DOI
Related Report
Peer Reviewed
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[Journal Article] Acute suppurative pancreatic ductitis associated with pancreatic duct obstruction.2013
Author(s)
Fujinaga T, Nishida T, Miyazaki M, Shigekawa M, Ikezawa K, Iwahashi K, Inoue T, Yamada T, Ezaki H, Shinzaki S, Yakushijin T, Iijima H, Tsujii M, Takehara T.
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Journal Title
Endoscopy
Volume: 45
Issue: S 02
Pages: 135-135
DOI
Related Report
Peer Reviewed
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[Journal Article] CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis.2013
Author(s)
Hayashi Y, Tsujii M, Wang J, Kondo J, Akasaka T, Jin Y, Li W, Nakamura T, Nishida T, Iijima H, Tsuji S, Kawano S, Hayashi N, Takehara T.
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Journal Title
GUT
Volume: 62
Issue: 11
Pages: 1536-1546
DOI
Related Report
Peer Reviewed
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[Journal Article] Gastric ESD under Heparin Replacement at High-Risk Patients of Thromboembolism Is Technically Feasible but Has a High Risk of Delayed Bleeding: Osaka University ESD Study Group.2013
Author(s)
Yoshio T, Nishida T, Kawai N, Yuguchi K, Yamada T, Yabuta T, Komori M, Yamaguchi S, Kitamura S, Iijima H, Tsutsui S, Michida T, Mita E, Tsujii M, Takehara T.
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Journal Title
Gastroenterol Res Pract.
Volume: 2013
Pages: 365830-365830
DOI
Related Report
Peer Reviewed
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[Journal Article] Narrow Band Imaging with Magnifying Endoscopy for Peyer's Patches in Patients with Inflammatory Bowel Disease2013
Author(s)
Hiyama, S., Iijima, H., Shinzaki, S., Mukai, A., Inoue, T., Shiraishi, E., Kawai, S., Yamada, T., Nishida, T., Tsujii, M., Takehara, T.
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Journal Title
Digestion
Volume: 87
Issue: 4
Pages: 269-80
DOI
Related Report
Peer Reviewed
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[Presentation] Vitamin K-deficiency deteriorates murine dextran sodium salt-induced colitis.2014
Author(s)
Iijima H, Shiraishi E, Shinzaki S, Inoue T, Hiyama S, Kawai S, Araki M, Nakajima S, Hayashi Y, Nishida T, Tsujii M, Takehara T.
Organizer
The 2nd Annual Meeting of Asian Organization for Crohn’s & Colitis
Place of Presentation
Seoul, Korea
Year and Date
2014-06-19 – 2014-06-21
Related Report
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